Correlation of Interleukin-10 and Interleukin-8 with Cytomegalovirus and Epstein–Barr Virus Infection in Hemodialysis Patients
Background: Herpes viruses like cytomegalovirus (CMV) and Epstein–Barr virus (EBV) can cause serious illness in those who already have impaired immune systems. Objectives: The purpose of this research was to examine the impact of CMV and EBV infection on specific immunological markers in individuals...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-10-01
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| Series: | Medical Journal of Babylon |
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| Online Access: | https://doi.org/10.4103/MJBL.MJBL_780_23 |
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| author | Eman Ammar Ihsan Lezan Medhat Mohammed Waleed Mohammed Ali |
| author_facet | Eman Ammar Ihsan Lezan Medhat Mohammed Waleed Mohammed Ali |
| author_sort | Eman Ammar Ihsan |
| collection | DOAJ |
| description | Background: Herpes viruses like cytomegalovirus (CMV) and Epstein–Barr virus (EBV) can cause serious illness in those who already have impaired immune systems. Objectives: The purpose of this research was to examine the impact of CMV and EBV infection on specific immunological markers in individuals undergoing hemodialysis. Materials and Methods: Blood sample was collected from 91 hemodialysis patients and 50 healthy individuals as a control group for comparison. Serum was separated and examined for the confirmation of CMV and EBV infection, and then the sera was tested by using specific ELISA kits (human interleukin-10 and human IL-8, Sunlong Biotech Co., HangZhou, China). Results: Highest mean of IL-8 and IL-10 was obtained in CMV IgM positive patients in comparison with IgG positive and control group with P value = 0.00002, 0.0008, respectively. The results in patients with EBV IgM positive were also highly significant in comparison with control, P value for IL-8 was 0.0002 and for IL-10 was 0.00004. Conclusion: The study concluded that, the level of IL-10 and IL-8 was higher among hemodialysis patients with acute EBV and CMV infection, and this indicated that the ability of CMV and EBV to enhance IL-8 and IL-10 production which may play an important role in immune inflammatory states associated with CMV and EBV infection. |
| format | Article |
| id | doaj-art-869dc321b09b4dccb422fd71096eedda |
| institution | Kabale University |
| issn | 1812-156X 2312-6760 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Medical Journal of Babylon |
| spelling | doaj-art-869dc321b09b4dccb422fd71096eedda2025-01-14T11:24:47ZengWolters Kluwer Medknow PublicationsMedical Journal of Babylon1812-156X2312-67602024-10-0121Suppl 2S195S19810.4103/MJBL.MJBL_780_23Correlation of Interleukin-10 and Interleukin-8 with Cytomegalovirus and Epstein–Barr Virus Infection in Hemodialysis PatientsEman Ammar IhsanLezan Medhat MohammedWaleed Mohammed AliBackground: Herpes viruses like cytomegalovirus (CMV) and Epstein–Barr virus (EBV) can cause serious illness in those who already have impaired immune systems. Objectives: The purpose of this research was to examine the impact of CMV and EBV infection on specific immunological markers in individuals undergoing hemodialysis. Materials and Methods: Blood sample was collected from 91 hemodialysis patients and 50 healthy individuals as a control group for comparison. Serum was separated and examined for the confirmation of CMV and EBV infection, and then the sera was tested by using specific ELISA kits (human interleukin-10 and human IL-8, Sunlong Biotech Co., HangZhou, China). Results: Highest mean of IL-8 and IL-10 was obtained in CMV IgM positive patients in comparison with IgG positive and control group with P value = 0.00002, 0.0008, respectively. The results in patients with EBV IgM positive were also highly significant in comparison with control, P value for IL-8 was 0.0002 and for IL-10 was 0.00004. Conclusion: The study concluded that, the level of IL-10 and IL-8 was higher among hemodialysis patients with acute EBV and CMV infection, and this indicated that the ability of CMV and EBV to enhance IL-8 and IL-10 production which may play an important role in immune inflammatory states associated with CMV and EBV infection.https://doi.org/10.4103/MJBL.MJBL_780_23cmvebvhemodialysisimmunological markers |
| spellingShingle | Eman Ammar Ihsan Lezan Medhat Mohammed Waleed Mohammed Ali Correlation of Interleukin-10 and Interleukin-8 with Cytomegalovirus and Epstein–Barr Virus Infection in Hemodialysis Patients Medical Journal of Babylon cmv ebv hemodialysis immunological markers |
| title | Correlation of Interleukin-10 and Interleukin-8 with Cytomegalovirus and Epstein–Barr Virus Infection in Hemodialysis Patients |
| title_full | Correlation of Interleukin-10 and Interleukin-8 with Cytomegalovirus and Epstein–Barr Virus Infection in Hemodialysis Patients |
| title_fullStr | Correlation of Interleukin-10 and Interleukin-8 with Cytomegalovirus and Epstein–Barr Virus Infection in Hemodialysis Patients |
| title_full_unstemmed | Correlation of Interleukin-10 and Interleukin-8 with Cytomegalovirus and Epstein–Barr Virus Infection in Hemodialysis Patients |
| title_short | Correlation of Interleukin-10 and Interleukin-8 with Cytomegalovirus and Epstein–Barr Virus Infection in Hemodialysis Patients |
| title_sort | correlation of interleukin 10 and interleukin 8 with cytomegalovirus and epstein barr virus infection in hemodialysis patients |
| topic | cmv ebv hemodialysis immunological markers |
| url | https://doi.org/10.4103/MJBL.MJBL_780_23 |
| work_keys_str_mv | AT emanammarihsan correlationofinterleukin10andinterleukin8withcytomegalovirusandepsteinbarrvirusinfectioninhemodialysispatients AT lezanmedhatmohammed correlationofinterleukin10andinterleukin8withcytomegalovirusandepsteinbarrvirusinfectioninhemodialysispatients AT waleedmohammedali correlationofinterleukin10andinterleukin8withcytomegalovirusandepsteinbarrvirusinfectioninhemodialysispatients |