Evaluation of clopidogrel, hypercoagulability, and platelet count in dogs undergoing splenectomy for splenic masses
Dogs that had splenectomy are predisposed to fatal thrombotic conditions, and thrombocytosis is a risk factor for post-splenectomy hypercoagulability. However, in veterinary medicine, there are no specific therapeutic approaches for managing this hypercoagulability. This study aimed to determine the...
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Taylor & Francis Group
2024-12-01
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| Series: | Veterinary Quarterly |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/01652176.2024.2347926 |
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| author | Guk-Il Joung Jeong-Yeol Bae Jung-Il Kim Jin-Young Kim Joong-Hyun Song |
| author_facet | Guk-Il Joung Jeong-Yeol Bae Jung-Il Kim Jin-Young Kim Joong-Hyun Song |
| author_sort | Guk-Il Joung |
| collection | DOAJ |
| description | Dogs that had splenectomy are predisposed to fatal thrombotic conditions, and thrombocytosis is a risk factor for post-splenectomy hypercoagulability. However, in veterinary medicine, there are no specific therapeutic approaches for managing this hypercoagulability. This study aimed to determine the preventive effect of clopidogrel on post-operative hypercoagulability during the first 2 weeks post-splenectomy in dogs with splenic masses. This study included 12 dogs that had splenectomy. Seven dogs received no treatment (group A), and five were treated with clopidogrel (group B). Clopidogrel was loaded at 10 mg/kg on day 2 and continued at 2 mg/kg until day 14. Blood samples were collected on the day of surgery and 2, 7, and 14 days after splenectomy in both groups. In group B, thromboelastography (TEG) was performed on the same days. In group A, there was significant elevation of platelet counts on days 7 (p = 0.007) and 14 (p = 0.001) compared to day 0. In group B, the platelet counts were significantly elevated on day 7 (p = 0.032) but no significant difference was found on day 14 compared to day 0. Platelet counts on day 14 were significantly higher in group A than in group B (p = 0.03). The lower platelet counts were correlated with alterations in TEG parameters, and no significant differences were found in the K and α-angle values at all postoperative assessment points compared to day 0. Our study suggests that clopidogrel may reduce post-operative thrombocytosis and hypercoagulability in dogs that undergo splenectomy for splenic masses. |
| format | Article |
| id | doaj-art-869b0d0ddec74991baeb227eaa6a16f6 |
| institution | Kabale University |
| issn | 0165-2176 1875-5941 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Veterinary Quarterly |
| spelling | doaj-art-869b0d0ddec74991baeb227eaa6a16f62024-12-03T17:25:18ZengTaylor & Francis GroupVeterinary Quarterly0165-21761875-59412024-12-014411810.1080/01652176.2024.2347926Evaluation of clopidogrel, hypercoagulability, and platelet count in dogs undergoing splenectomy for splenic massesGuk-Il Joung0Jeong-Yeol Bae1Jung-Il Kim2Jin-Young Kim3Joong-Hyun Song4Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon, South KoreaDepartment of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon, South KoreaDepartment of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon, South KoreaDepartment of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon, South KoreaDepartment of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon, South KoreaDogs that had splenectomy are predisposed to fatal thrombotic conditions, and thrombocytosis is a risk factor for post-splenectomy hypercoagulability. However, in veterinary medicine, there are no specific therapeutic approaches for managing this hypercoagulability. This study aimed to determine the preventive effect of clopidogrel on post-operative hypercoagulability during the first 2 weeks post-splenectomy in dogs with splenic masses. This study included 12 dogs that had splenectomy. Seven dogs received no treatment (group A), and five were treated with clopidogrel (group B). Clopidogrel was loaded at 10 mg/kg on day 2 and continued at 2 mg/kg until day 14. Blood samples were collected on the day of surgery and 2, 7, and 14 days after splenectomy in both groups. In group B, thromboelastography (TEG) was performed on the same days. In group A, there was significant elevation of platelet counts on days 7 (p = 0.007) and 14 (p = 0.001) compared to day 0. In group B, the platelet counts were significantly elevated on day 7 (p = 0.032) but no significant difference was found on day 14 compared to day 0. Platelet counts on day 14 were significantly higher in group A than in group B (p = 0.03). The lower platelet counts were correlated with alterations in TEG parameters, and no significant differences were found in the K and α-angle values at all postoperative assessment points compared to day 0. Our study suggests that clopidogrel may reduce post-operative thrombocytosis and hypercoagulability in dogs that undergo splenectomy for splenic masses.https://www.tandfonline.com/doi/10.1080/01652176.2024.2347926Clopidogreldoghypercoagulabilitysplenectomythrombocytosis |
| spellingShingle | Guk-Il Joung Jeong-Yeol Bae Jung-Il Kim Jin-Young Kim Joong-Hyun Song Evaluation of clopidogrel, hypercoagulability, and platelet count in dogs undergoing splenectomy for splenic masses Veterinary Quarterly Clopidogrel dog hypercoagulability splenectomy thrombocytosis |
| title | Evaluation of clopidogrel, hypercoagulability, and platelet count in dogs undergoing splenectomy for splenic masses |
| title_full | Evaluation of clopidogrel, hypercoagulability, and platelet count in dogs undergoing splenectomy for splenic masses |
| title_fullStr | Evaluation of clopidogrel, hypercoagulability, and platelet count in dogs undergoing splenectomy for splenic masses |
| title_full_unstemmed | Evaluation of clopidogrel, hypercoagulability, and platelet count in dogs undergoing splenectomy for splenic masses |
| title_short | Evaluation of clopidogrel, hypercoagulability, and platelet count in dogs undergoing splenectomy for splenic masses |
| title_sort | evaluation of clopidogrel hypercoagulability and platelet count in dogs undergoing splenectomy for splenic masses |
| topic | Clopidogrel dog hypercoagulability splenectomy thrombocytosis |
| url | https://www.tandfonline.com/doi/10.1080/01652176.2024.2347926 |
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