Evaluating bioactivity retention in metabolism: a comparative study of chlorogenic acid and its metabolite dihydrocaffeic acid on antioxidant, anti-inflammatory, and anti-obesogenic activities in vitro
This study investigates the bioactivity retention of chlorogenic acid (CGA) and its metabolite dihydrocaffeic acid (DHCA) by comparing their antioxidant, anti-inflammatory, and anti-obesogenic properties in vitro. CGA, found in coffee, fruits, and vegetables, is metabolized into DHCA, potentially en...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | CyTA - Journal of Food |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19476337.2024.2390997 |
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| author | Edwin Estefan Reza-Zaldivar Daniel A. Jacobo-Velázquez |
| author_facet | Edwin Estefan Reza-Zaldivar Daniel A. Jacobo-Velázquez |
| author_sort | Edwin Estefan Reza-Zaldivar |
| collection | DOAJ |
| description | This study investigates the bioactivity retention of chlorogenic acid (CGA) and its metabolite dihydrocaffeic acid (DHCA) by comparing their antioxidant, anti-inflammatory, and anti-obesogenic properties in vitro. CGA, found in coffee, fruits, and vegetables, is metabolized into DHCA, potentially enhancing bioactivity. Antioxidant capacity was assessed in Caco-2 cells, with DHCA showing superior activity at lower concentrations than CGA. Anti-inflammatory effects were evaluated in LPS-stimulated RAW 264.7 cells, where DHCA exhibited significant dose-dependent inhibition of nitrite production, surpassing CGA. Anti-obesogenic potential was analyzed in 3T3-L1 cells, with DHCA demonstrating stronger inhibition of adipogenesis and notable downregulation of adipogenic genes like PPARγ and C/EBPα. These results suggest that DHCA’s enhanced therapeutic potential due to its simplified structure and increased bioavailability. This study highlights the importance of metabolic transformations in dietary polyphenols for chronic disease prevention and management. |
| format | Article |
| id | doaj-art-86738a417d764f9fb67cab319c4782a2 |
| institution | Kabale University |
| issn | 1947-6337 1947-6345 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | CyTA - Journal of Food |
| spelling | doaj-art-86738a417d764f9fb67cab319c4782a22024-12-18T13:34:51ZengTaylor & Francis GroupCyTA - Journal of Food1947-63371947-63452024-12-0122110.1080/19476337.2024.2390997Evaluating bioactivity retention in metabolism: a comparative study of chlorogenic acid and its metabolite dihydrocaffeic acid on antioxidant, anti-inflammatory, and anti-obesogenic activities in vitroEdwin Estefan Reza-Zaldivar0Daniel A. Jacobo-Velázquez1Tecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Campus Guadalajara, Zapopan, Jalisco, MéxicoTecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Campus Guadalajara, Zapopan, Jalisco, MéxicoThis study investigates the bioactivity retention of chlorogenic acid (CGA) and its metabolite dihydrocaffeic acid (DHCA) by comparing their antioxidant, anti-inflammatory, and anti-obesogenic properties in vitro. CGA, found in coffee, fruits, and vegetables, is metabolized into DHCA, potentially enhancing bioactivity. Antioxidant capacity was assessed in Caco-2 cells, with DHCA showing superior activity at lower concentrations than CGA. Anti-inflammatory effects were evaluated in LPS-stimulated RAW 264.7 cells, where DHCA exhibited significant dose-dependent inhibition of nitrite production, surpassing CGA. Anti-obesogenic potential was analyzed in 3T3-L1 cells, with DHCA demonstrating stronger inhibition of adipogenesis and notable downregulation of adipogenic genes like PPARγ and C/EBPα. These results suggest that DHCA’s enhanced therapeutic potential due to its simplified structure and increased bioavailability. This study highlights the importance of metabolic transformations in dietary polyphenols for chronic disease prevention and management.https://www.tandfonline.com/doi/10.1080/19476337.2024.2390997Chlorogenic aciddihydrocaffeic acidmetabolic transformationmetabolitesobesitymetabolic syndrome |
| spellingShingle | Edwin Estefan Reza-Zaldivar Daniel A. Jacobo-Velázquez Evaluating bioactivity retention in metabolism: a comparative study of chlorogenic acid and its metabolite dihydrocaffeic acid on antioxidant, anti-inflammatory, and anti-obesogenic activities in vitro CyTA - Journal of Food Chlorogenic acid dihydrocaffeic acid metabolic transformation metabolites obesity metabolic syndrome |
| title | Evaluating bioactivity retention in metabolism: a comparative study of chlorogenic acid and its metabolite dihydrocaffeic acid on antioxidant, anti-inflammatory, and anti-obesogenic activities in vitro |
| title_full | Evaluating bioactivity retention in metabolism: a comparative study of chlorogenic acid and its metabolite dihydrocaffeic acid on antioxidant, anti-inflammatory, and anti-obesogenic activities in vitro |
| title_fullStr | Evaluating bioactivity retention in metabolism: a comparative study of chlorogenic acid and its metabolite dihydrocaffeic acid on antioxidant, anti-inflammatory, and anti-obesogenic activities in vitro |
| title_full_unstemmed | Evaluating bioactivity retention in metabolism: a comparative study of chlorogenic acid and its metabolite dihydrocaffeic acid on antioxidant, anti-inflammatory, and anti-obesogenic activities in vitro |
| title_short | Evaluating bioactivity retention in metabolism: a comparative study of chlorogenic acid and its metabolite dihydrocaffeic acid on antioxidant, anti-inflammatory, and anti-obesogenic activities in vitro |
| title_sort | evaluating bioactivity retention in metabolism a comparative study of chlorogenic acid and its metabolite dihydrocaffeic acid on antioxidant anti inflammatory and anti obesogenic activities in vitro |
| topic | Chlorogenic acid dihydrocaffeic acid metabolic transformation metabolites obesity metabolic syndrome |
| url | https://www.tandfonline.com/doi/10.1080/19476337.2024.2390997 |
| work_keys_str_mv | AT edwinestefanrezazaldivar evaluatingbioactivityretentioninmetabolismacomparativestudyofchlorogenicacidanditsmetabolitedihydrocaffeicacidonantioxidantantiinflammatoryandantiobesogenicactivitiesinvitro AT danielajacobovelazquez evaluatingbioactivityretentioninmetabolismacomparativestudyofchlorogenicacidanditsmetabolitedihydrocaffeicacidonantioxidantantiinflammatoryandantiobesogenicactivitiesinvitro |