Alterations of PINK1-PRKN signaling in mice during normal aging

Alterations of PINK1-PRKN signaling in mice during normal aging

The ubiquitin kinase-ligase pair PINK1-PRKN identifies and selectively marks damaged mitochondria for elimination via the autophagy-lysosome system (mitophagy). While this cytoprotective pathway has been extensively studied in vitro upon acute and complete depolarization of mitochondria, the signifi...

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Main Authors: Zahra Baninameh, Jens O. Watzlawik, Xu Hou, Tyrique Richardson, Nicholas W. Kurchaba, Tingxiang Yan, Damian N. Di Florio, DeLisa Fairweather, Lu Kang, Justin H. Nguyen, Takahisa Kanekiyo, Dennis W. Dickson, Sachiko Noda, Shigeto Sato, Nobutaka Hattori, Matthew S. Goldberg, Ian G. Ganley, Kelly L. Stauch, Fabienne C. Fiesel, Wolfdieter Springer
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Autophagy Reports
Subjects:
aging
brain
heart
mice
mitochondria
mitophagy
Online Access:https://www.tandfonline.com/doi/10.1080/27694127.2024.2434379
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