Single-cell transcriptome analysis of medaka lymphocytes reveals absence of fully mature T cells in the thymus and the T-lineage commitment in the kidney

Single-cell transcriptome analysis of medaka lymphocytes reveals absence of fully mature T cells in the thymus and the T-lineage commitment in the kidney

The cellular and molecular mechanisms underlying lymphocyte development are diverse among teleost species. Although recent scRNA-seq analyses of zebrafish hematopoietic cells have advanced our understanding of teleost hematopoiesis, comparative studies using another genetic model, medaka, which is e...

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Bibliographic Details
Main Authors: Hiyori Sakaguchi, Masaru Matsuda, Norimasa Iwanami
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
medaka
immune system
lymphopoiesis
scRNA-seq
rag1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1517467/full
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