Spine health: Back pain and deformity progression
Back pain and spinal deformity arising from a variety of etiologies are closely linked to alterations in bone health. This review is intended to summarize the known processes for each of these conditions that negatively impact bone health. It will then elucidate how poor bone quality can further wor...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-05-01
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| Series: | Journal of the Pediatric Orthopaedic Society of North America |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2768276524008885 |
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| author | Chinmay S. Paranjape, MD, MHSc Michelle C. Welborn, MD |
| author_facet | Chinmay S. Paranjape, MD, MHSc Michelle C. Welborn, MD |
| author_sort | Chinmay S. Paranjape, MD, MHSc |
| collection | DOAJ |
| description | Back pain and spinal deformity arising from a variety of etiologies are closely linked to alterations in bone health. This review is intended to summarize the known processes for each of these conditions that negatively impact bone health. It will then elucidate how poor bone quality can further worsen deformity. Finally, it will discuss how interventions targeting improvement in bone health may affect treatment and progression of deformity. Key Concepts: (1) Back pain is highly prevalent affecting up to a third of adolescents and is even more so in patients who are vitamin D deficient. (2) Scoliosis patients from various etiologies all experience higher rates of back pain and tend to have lower bone mineral density than their healthy pediatric peers. (3) There is an interplay between deformity and bone health, where deformity can both drive and be driven by bone health. (4) Treatments targeting bone health may positively affect both natural history and surgical outcomes for patients who have scoliosis with various underlying etiologies. (5) Further research is needed to elucidate mechanistic pathways that link bone health to deformity and to evaluate targets for therapy. |
| format | Article |
| id | doaj-art-865c7de79d97433daf39ce75d5d4c19f |
| institution | Kabale University |
| issn | 2768-2765 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Pediatric Orthopaedic Society of North America |
| spelling | doaj-art-865c7de79d97433daf39ce75d5d4c19f2024-11-21T06:06:56ZengElsevierJournal of the Pediatric Orthopaedic Society of North America2768-27652024-05-017100062Spine health: Back pain and deformity progressionChinmay S. Paranjape, MD, MHSc0Michelle C. Welborn, MD1Corresponding author: 3101 SW Sam Jackson Park Rd., Portland, OR 97229, USA.; Portland Shriner’s Hospital for Children, Portland, OR, USAPortland Shriner’s Hospital for Children, Portland, OR, USABack pain and spinal deformity arising from a variety of etiologies are closely linked to alterations in bone health. This review is intended to summarize the known processes for each of these conditions that negatively impact bone health. It will then elucidate how poor bone quality can further worsen deformity. Finally, it will discuss how interventions targeting improvement in bone health may affect treatment and progression of deformity. Key Concepts: (1) Back pain is highly prevalent affecting up to a third of adolescents and is even more so in patients who are vitamin D deficient. (2) Scoliosis patients from various etiologies all experience higher rates of back pain and tend to have lower bone mineral density than their healthy pediatric peers. (3) There is an interplay between deformity and bone health, where deformity can both drive and be driven by bone health. (4) Treatments targeting bone health may positively affect both natural history and surgical outcomes for patients who have scoliosis with various underlying etiologies. (5) Further research is needed to elucidate mechanistic pathways that link bone health to deformity and to evaluate targets for therapy.http://www.sciencedirect.com/science/article/pii/S2768276524008885SpineBone healthPainScoliosisOsteogenesis imperfectaSpondylolisthesis |
| spellingShingle | Chinmay S. Paranjape, MD, MHSc Michelle C. Welborn, MD Spine health: Back pain and deformity progression Journal of the Pediatric Orthopaedic Society of North America Spine Bone health Pain Scoliosis Osteogenesis imperfecta Spondylolisthesis |
| title | Spine health: Back pain and deformity progression |
| title_full | Spine health: Back pain and deformity progression |
| title_fullStr | Spine health: Back pain and deformity progression |
| title_full_unstemmed | Spine health: Back pain and deformity progression |
| title_short | Spine health: Back pain and deformity progression |
| title_sort | spine health back pain and deformity progression |
| topic | Spine Bone health Pain Scoliosis Osteogenesis imperfecta Spondylolisthesis |
| url | http://www.sciencedirect.com/science/article/pii/S2768276524008885 |
| work_keys_str_mv | AT chinmaysparanjapemdmhsc spinehealthbackpainanddeformityprogression AT michellecwelbornmd spinehealthbackpainanddeformityprogression |