Molecular Mechanisms of Breast Cancer Drug Resistance and CRISPR/Cas9 Strategies to Overcome
Breast cancer (BC) is considered as the most frequent cancer among women and a significant contributor to mortality. The CRISPR/Cas9 gene-editing tool has promising applications for BC drug resistance. It is a unique and creative approach that has lately attracted attention and can be used to fix ge...
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| Format: | Article |
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2024-12-01
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| Series: | BioMed Target Journal |
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| Online Access: | https://qaaspa.com/index.php/bmtj/article/view/26 |
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| author | Bashdar Mahmud Hussen Bnar Saleh Ismael Saman S. Abdulla Noor Haval Jamal Suhad Asad Mustafa Zana Baqi Najmalddin Mohammed Fatih Rasul |
| author_facet | Bashdar Mahmud Hussen Bnar Saleh Ismael Saman S. Abdulla Noor Haval Jamal Suhad Asad Mustafa Zana Baqi Najmalddin Mohammed Fatih Rasul |
| author_sort | Bashdar Mahmud Hussen |
| collection | DOAJ |
| description | Breast cancer (BC) is considered as the most frequent cancer among women and a significant contributor to mortality. The CRISPR/Cas9 gene-editing tool has promising applications for BC drug resistance. It is a unique and creative approach that has lately attracted attention and can be used to fix gene alterations related to multidrug resistance. Recent research has effectively investigated and targeted particular genes linked to BC treatment resistance using CRISPR/Cas9 gene editing, including those linked to hormone receptor signaling, drug efflux transporters, and DNA repair pathways. The CRISPR/Cas9 technology's selective disruption or mutation of these genes provides valuable information about their role in resistance and paves the path for cutting-edge treatment options. CRISPR/Cas9 gene editing can overcome BC treatment resistance by identifying crucial genetic variables and revealing new therapeutic targets Despite the advantages, there are limitations in the study on CRISPR/Cas9-based gene editing for BC treatment resistance, for example, off-target effects and the improvement of delivery techniques are still major issues. Successful clinical translation depends on methods to improve the specificity and effectiveness of CRISPR/Cas9 editing and to solve these constraints. This review aims to explore the possibility of CRISPR/Cas9 gene editing as an innovative method of combating BC medication resistance. |
| format | Article |
| id | doaj-art-86421fe752cf4368a813d855ec4a797f |
| institution | Kabale University |
| issn | 2960-1428 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | QAASPA Publisher |
| record_format | Article |
| series | BioMed Target Journal |
| spelling | doaj-art-86421fe752cf4368a813d855ec4a797f2025-01-10T21:54:26ZengQAASPA PublisherBioMed Target Journal2960-14282024-12-012212010.59786/bmtj.22126Molecular Mechanisms of Breast Cancer Drug Resistance and CRISPR/Cas9 Strategies to OvercomeBashdar Mahmud Hussen0https://orcid.org/0000-0003-1060-6527Bnar Saleh Ismael1https://orcid.org/0000-0002-0679-8944Saman S. Abdulla2https://orcid.org/0000-0002-9091-0184Noor Haval Jamal3https://orcid.org/0009-0001-3473-9431Suhad Asad Mustafa4https://orcid.org/0000-0002-6774-2979Zana Baqi Najmalddin5https://orcid.org/0000-0002-0533-8735Mohammed Fatih Rasul6https://orcid.org/0000-0003-4742-230XDepartment of Biomedical Sciences, College of Science, Cihan University-Erbil, Erbil, 44001, Iraq Department of Clinical Analysis, College of Pharmacy, Hawler Medical University, Erbil, 44001, IraqDepartment of Pharmacology and Toxicology, College of Pharmacy, Hawler Medical University, Erbil, 44001, IraqCollege of Medicine, Hawler Medical University, Erbil, 44001, IraqDepartment of Nursing, Pirmam Technical and Vocational Institute, Erbil, 44001, IraqGeneral Directorate of Scientific Research Center, Salahaddin University-Erbil, Erbil, 44001, IraqResearch Center, University of Halabja, Halabja, 46018, IraqDepartment of Pharmaceutical Basic Science, Faculty of Pharmacy, Tishk International University, Erbil, 44001, IraqBreast cancer (BC) is considered as the most frequent cancer among women and a significant contributor to mortality. The CRISPR/Cas9 gene-editing tool has promising applications for BC drug resistance. It is a unique and creative approach that has lately attracted attention and can be used to fix gene alterations related to multidrug resistance. Recent research has effectively investigated and targeted particular genes linked to BC treatment resistance using CRISPR/Cas9 gene editing, including those linked to hormone receptor signaling, drug efflux transporters, and DNA repair pathways. The CRISPR/Cas9 technology's selective disruption or mutation of these genes provides valuable information about their role in resistance and paves the path for cutting-edge treatment options. CRISPR/Cas9 gene editing can overcome BC treatment resistance by identifying crucial genetic variables and revealing new therapeutic targets Despite the advantages, there are limitations in the study on CRISPR/Cas9-based gene editing for BC treatment resistance, for example, off-target effects and the improvement of delivery techniques are still major issues. Successful clinical translation depends on methods to improve the specificity and effectiveness of CRISPR/Cas9 editing and to solve these constraints. This review aims to explore the possibility of CRISPR/Cas9 gene editing as an innovative method of combating BC medication resistance.https://qaaspa.com/index.php/bmtj/article/view/26breast cancerdrug resistancecrispr/cas9 |
| spellingShingle | Bashdar Mahmud Hussen Bnar Saleh Ismael Saman S. Abdulla Noor Haval Jamal Suhad Asad Mustafa Zana Baqi Najmalddin Mohammed Fatih Rasul Molecular Mechanisms of Breast Cancer Drug Resistance and CRISPR/Cas9 Strategies to Overcome BioMed Target Journal breast cancer drug resistance crispr/cas9 |
| title | Molecular Mechanisms of Breast Cancer Drug Resistance and CRISPR/Cas9 Strategies to Overcome |
| title_full | Molecular Mechanisms of Breast Cancer Drug Resistance and CRISPR/Cas9 Strategies to Overcome |
| title_fullStr | Molecular Mechanisms of Breast Cancer Drug Resistance and CRISPR/Cas9 Strategies to Overcome |
| title_full_unstemmed | Molecular Mechanisms of Breast Cancer Drug Resistance and CRISPR/Cas9 Strategies to Overcome |
| title_short | Molecular Mechanisms of Breast Cancer Drug Resistance and CRISPR/Cas9 Strategies to Overcome |
| title_sort | molecular mechanisms of breast cancer drug resistance and crispr cas9 strategies to overcome |
| topic | breast cancer drug resistance crispr/cas9 |
| url | https://qaaspa.com/index.php/bmtj/article/view/26 |
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