S100 calcium-binding protein A8 exacerbates deep vein thrombosis in vascular endothelial cells
Abstract Previous studies highlighting the pivotal function of the S100A8 protein have shown that inflammation and vascular endothelial harm play a major role in deep vein thrombosis (DVT) development, as evidenced by earlier studies highlighting the pivotal function of the S100 calcium-binding prot...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-85322-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841559673477529600 |
|---|---|
| author | Junyu Chi Qitao Wang Zhen Wang Wenjie Zeng Yangyang Gao Xin Li Wanpeng Wang Jiali Wang Ming Qu |
| author_facet | Junyu Chi Qitao Wang Zhen Wang Wenjie Zeng Yangyang Gao Xin Li Wanpeng Wang Jiali Wang Ming Qu |
| author_sort | Junyu Chi |
| collection | DOAJ |
| description | Abstract Previous studies highlighting the pivotal function of the S100A8 protein have shown that inflammation and vascular endothelial harm play a major role in deep vein thrombosis (DVT) development, as evidenced by earlier studies highlighting the pivotal function of the S100 calcium-binding protein A8 (S100A8). Therefore, we aimed to establish a connection between S100A8 and DVT and investigate the role of S100A8 in DVT development. Blood specimens were taken from 23 patients with DVT and 31 controls. The fluctuation and association for S100A8 and interleukin-1 beta (IL-1β) in the specimens was assessed using enzyme-linked immunosorbent assay. We also used the human recombinant protein S100A8 to activate human umbilical vein endothelial cells and created a rat model to explore the possible relationship between them. Studies have shown that the infiltration of S100A8 sustains local inflammation and thrombus formation, which may exacerbate DVT by amplifying NLRP3/Caspase-1/IL-1β signals in the vascular endothelial cells. |
| format | Article |
| id | doaj-art-862add212a3647a6ba155595deec3ab5 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-862add212a3647a6ba155595deec3ab52025-01-05T12:18:25ZengNature PortfolioScientific Reports2045-23222025-01-0115111110.1038/s41598-025-85322-6S100 calcium-binding protein A8 exacerbates deep vein thrombosis in vascular endothelial cellsJunyu Chi0Qitao Wang1Zhen Wang2Wenjie Zeng3Yangyang Gao4Xin Li5Wanpeng Wang6Jiali Wang7Ming Qu8Vascular Gland Surgery, The First Affiliated Hospital of Hebei North UniversityVascular Gland Surgery, The First Affiliated Hospital of Hebei North UniversityVascular Gland Surgery, The First Affiliated Hospital of Hebei North UniversityXiangya Hospital Central South UniversityVascular Gland Surgery, The First Affiliated Hospital of Hebei North UniversityVascular Gland Surgery, The First Affiliated Hospital of Hebei North UniversityVascular Gland Surgery, The First Affiliated Hospital of Hebei North UniversityGraduate School of Hebei North UniversityVascular Gland Surgery, The First Affiliated Hospital of Hebei North UniversityAbstract Previous studies highlighting the pivotal function of the S100A8 protein have shown that inflammation and vascular endothelial harm play a major role in deep vein thrombosis (DVT) development, as evidenced by earlier studies highlighting the pivotal function of the S100 calcium-binding protein A8 (S100A8). Therefore, we aimed to establish a connection between S100A8 and DVT and investigate the role of S100A8 in DVT development. Blood specimens were taken from 23 patients with DVT and 31 controls. The fluctuation and association for S100A8 and interleukin-1 beta (IL-1β) in the specimens was assessed using enzyme-linked immunosorbent assay. We also used the human recombinant protein S100A8 to activate human umbilical vein endothelial cells and created a rat model to explore the possible relationship between them. Studies have shown that the infiltration of S100A8 sustains local inflammation and thrombus formation, which may exacerbate DVT by amplifying NLRP3/Caspase-1/IL-1β signals in the vascular endothelial cells.https://doi.org/10.1038/s41598-025-85322-6 |
| spellingShingle | Junyu Chi Qitao Wang Zhen Wang Wenjie Zeng Yangyang Gao Xin Li Wanpeng Wang Jiali Wang Ming Qu S100 calcium-binding protein A8 exacerbates deep vein thrombosis in vascular endothelial cells Scientific Reports |
| title | S100 calcium-binding protein A8 exacerbates deep vein thrombosis in vascular endothelial cells |
| title_full | S100 calcium-binding protein A8 exacerbates deep vein thrombosis in vascular endothelial cells |
| title_fullStr | S100 calcium-binding protein A8 exacerbates deep vein thrombosis in vascular endothelial cells |
| title_full_unstemmed | S100 calcium-binding protein A8 exacerbates deep vein thrombosis in vascular endothelial cells |
| title_short | S100 calcium-binding protein A8 exacerbates deep vein thrombosis in vascular endothelial cells |
| title_sort | s100 calcium binding protein a8 exacerbates deep vein thrombosis in vascular endothelial cells |
| url | https://doi.org/10.1038/s41598-025-85322-6 |
| work_keys_str_mv | AT junyuchi s100calciumbindingproteina8exacerbatesdeepveinthrombosisinvascularendothelialcells AT qitaowang s100calciumbindingproteina8exacerbatesdeepveinthrombosisinvascularendothelialcells AT zhenwang s100calciumbindingproteina8exacerbatesdeepveinthrombosisinvascularendothelialcells AT wenjiezeng s100calciumbindingproteina8exacerbatesdeepveinthrombosisinvascularendothelialcells AT yangyanggao s100calciumbindingproteina8exacerbatesdeepveinthrombosisinvascularendothelialcells AT xinli s100calciumbindingproteina8exacerbatesdeepveinthrombosisinvascularendothelialcells AT wanpengwang s100calciumbindingproteina8exacerbatesdeepveinthrombosisinvascularendothelialcells AT jialiwang s100calciumbindingproteina8exacerbatesdeepveinthrombosisinvascularendothelialcells AT mingqu s100calciumbindingproteina8exacerbatesdeepveinthrombosisinvascularendothelialcells |