Difference in recurrence frequencies of non-muscle-invasive-bladder tumors depending on optimal usage of intravesical immunotherapy of bacillus Calmette-Guérin
Background/Aim. The therapy with intravesical instillation of bacillus Calmette-Guérin (BCG) after transurethral resection (TUR) of the tumor is the gold standard of treatment of non-muscle invasive bladder cancer (NMIBC). The aim of this study was to compare the frequencies of reccurence b...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2015-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501400072M.pdf |
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| Summary: | Background/Aim. The therapy with intravesical instillation of bacillus
Calmette-Guérin (BCG) after transurethral resection (TUR) of the tumor is the
gold standard of treatment of non-muscle invasive bladder cancer (NMIBC). The
aim of this study was to compare the frequencies of reccurence between a
group of patients submitted to TUR + BCG therapy (group I) and a group of
patients submitted only to TUR (group II). Methods. The patients with NMIBC,
a total of 899, treated in our Institution from January 1, 2007 to March,
2013, were included in this study and divided into two groups: group I and
group II. These two groups were divided into three subgroups: solitary first
diagnosed tumor ≤ 3 cm (SFDGT), solitary first diagnosed tumor > 3 cm and
multiple first diagnosed tumors (MFDGT), and recedive tumors (RCT).
Statistical analysis was performed by using χ2-test and Kolmogorov-Smirnov
test. Results: In the group I a total of 133 cases had reccurence contrary to
75 in the group II, making a statistically highly significant difference.
Analysis of recurrences through the subgroups revealed: in the group I SFDGT
recurrence occured in 27 of the cases vs 9 cases in the group II; in the
group I MFDGT recurrence occured in 49 of the cases vs 31 in the group II (p
< 0.001), and finally, in the group I RCT recurrence occured in 57 cases vs
35 cases in the group II (p < 0.001). Conclusion. The obtained results
indicate no difference in the frequency of reccurence between the group I and
group II regarding SFDGT, but a very high significant difference regarding
those with MFDGT and RCT. These results should be taken into consideration in
everyday clinical practise. |
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| ISSN: | 0042-8450 |