P-95 SARCOPENIA: RISK FACTOR FOR MORTALITY IN CIRRHOTIC PATIENTS ON WAITING LIST FOR LIVER TRANSPLANTATION IN A REFERENCE CENTER, COLOMBIA
Conflict of interest: No Introduction and Objectives: Sarcopenia is an independent predictor of mortality in patients with chronic liver disease pre- and post-transplant. Measurement of muscle strength by dynamometry can serve as a surrogate marker of frailty in patients with chronic liver disease,...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Annals of Hepatology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268124004927 |
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| author | Gustavo Andres Diaz Nassif Geovanny Hernandez Cely |
| author_facet | Gustavo Andres Diaz Nassif Geovanny Hernandez Cely |
| author_sort | Gustavo Andres Diaz Nassif |
| collection | DOAJ |
| description | Conflict of interest: No Introduction and Objectives: Sarcopenia is an independent predictor of mortality in patients with chronic liver disease pre- and post-transplant. Measurement of muscle strength by dynamometry can serve as a surrogate marker of frailty in patients with chronic liver disease, especially in those in whom it is not possible to assess sarcopenia through imaging. Patients / Materials and Methods: To determine the association between sarcopenia, complications of cirrhosis and mortality in cirrhotic patients on the waiting list for liver transplant in a liver transplant reference center in Colombia. Methods: An observational, analytical and retrospective study was carried out with a cohort of patients with cirrhosis on the waiting list for liver transplant between 2020 and 2022, in a liver transplant reference center in Colombia. Results and Discussion: We included 310 patients with a diagnosis of cirrhosis who were on the liver transplant waiting list and had dynamometry and anthropometry records to calculate the SARC-F index. A bivariate analysis was carried out which shows that a high score in CHILDA, MELD, ICU stay, complications such as SBP, dynamometry measurement and sarcopenia generate an estimate of significant association, taking into account a p <0.05. Subsequently, a multinomial logistic regression model was carried out, chronic kidney disease and sarcopenia stand out as influential factors in mortality with P <0.05. Conclusions: Sarcopenia and chronic kidney disease are factors that have a significant association with higher mortality. |
| format | Article |
| id | doaj-art-860646ab3d7a4f78ade682e6e67b3ec9 |
| institution | Kabale University |
| issn | 1665-2681 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj-art-860646ab3d7a4f78ade682e6e67b3ec92024-12-07T08:25:48ZengElsevierAnnals of Hepatology1665-26812024-12-0129101709P-95 SARCOPENIA: RISK FACTOR FOR MORTALITY IN CIRRHOTIC PATIENTS ON WAITING LIST FOR LIVER TRANSPLANTATION IN A REFERENCE CENTER, COLOMBIAGustavo Andres Diaz Nassif0Geovanny Hernandez Cely1Fellow Hepatologia, Universidad Del Rosario, Bogotá, ColombiaJefe Servicio De Gastroenterologia, Fundacion Cardio Infantil, Bogota, ColombiaConflict of interest: No Introduction and Objectives: Sarcopenia is an independent predictor of mortality in patients with chronic liver disease pre- and post-transplant. Measurement of muscle strength by dynamometry can serve as a surrogate marker of frailty in patients with chronic liver disease, especially in those in whom it is not possible to assess sarcopenia through imaging. Patients / Materials and Methods: To determine the association between sarcopenia, complications of cirrhosis and mortality in cirrhotic patients on the waiting list for liver transplant in a liver transplant reference center in Colombia. Methods: An observational, analytical and retrospective study was carried out with a cohort of patients with cirrhosis on the waiting list for liver transplant between 2020 and 2022, in a liver transplant reference center in Colombia. Results and Discussion: We included 310 patients with a diagnosis of cirrhosis who were on the liver transplant waiting list and had dynamometry and anthropometry records to calculate the SARC-F index. A bivariate analysis was carried out which shows that a high score in CHILDA, MELD, ICU stay, complications such as SBP, dynamometry measurement and sarcopenia generate an estimate of significant association, taking into account a p <0.05. Subsequently, a multinomial logistic regression model was carried out, chronic kidney disease and sarcopenia stand out as influential factors in mortality with P <0.05. Conclusions: Sarcopenia and chronic kidney disease are factors that have a significant association with higher mortality.http://www.sciencedirect.com/science/article/pii/S1665268124004927 |
| spellingShingle | Gustavo Andres Diaz Nassif Geovanny Hernandez Cely P-95 SARCOPENIA: RISK FACTOR FOR MORTALITY IN CIRRHOTIC PATIENTS ON WAITING LIST FOR LIVER TRANSPLANTATION IN A REFERENCE CENTER, COLOMBIA Annals of Hepatology |
| title | P-95 SARCOPENIA: RISK FACTOR FOR MORTALITY IN CIRRHOTIC PATIENTS ON WAITING LIST FOR LIVER TRANSPLANTATION IN A REFERENCE CENTER, COLOMBIA |
| title_full | P-95 SARCOPENIA: RISK FACTOR FOR MORTALITY IN CIRRHOTIC PATIENTS ON WAITING LIST FOR LIVER TRANSPLANTATION IN A REFERENCE CENTER, COLOMBIA |
| title_fullStr | P-95 SARCOPENIA: RISK FACTOR FOR MORTALITY IN CIRRHOTIC PATIENTS ON WAITING LIST FOR LIVER TRANSPLANTATION IN A REFERENCE CENTER, COLOMBIA |
| title_full_unstemmed | P-95 SARCOPENIA: RISK FACTOR FOR MORTALITY IN CIRRHOTIC PATIENTS ON WAITING LIST FOR LIVER TRANSPLANTATION IN A REFERENCE CENTER, COLOMBIA |
| title_short | P-95 SARCOPENIA: RISK FACTOR FOR MORTALITY IN CIRRHOTIC PATIENTS ON WAITING LIST FOR LIVER TRANSPLANTATION IN A REFERENCE CENTER, COLOMBIA |
| title_sort | p 95 sarcopenia risk factor for mortality in cirrhotic patients on waiting list for liver transplantation in a reference center colombia |
| url | http://www.sciencedirect.com/science/article/pii/S1665268124004927 |
| work_keys_str_mv | AT gustavoandresdiaznassif p95sarcopeniariskfactorformortalityincirrhoticpatientsonwaitinglistforlivertransplantationinareferencecentercolombia AT geovannyhernandezcely p95sarcopeniariskfactorformortalityincirrhoticpatientsonwaitinglistforlivertransplantationinareferencecentercolombia |