Successful Treatment of MDR Acinetobacter baumannii Meningitis in a Young Adult Patient With Intraventricular and Intravenous Polymyxin B‐Tigecycline Based Combinations: A Case Report
ABSTRACT Multiple drug resistance to Acinetobacter baumannii infection treatment is a great challenge for neuro‐intensivists due to poor drug penetration through the blood–brain barrier (BBB). Fortunately, the intraventricular administration of polymyxin‐B and tigecycline seems to be effective; ther...
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| Format: | Article |
| Language: | English |
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Wiley
2024-11-01
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| Series: | Clinical Case Reports |
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| Online Access: | https://doi.org/10.1002/ccr3.9559 |
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| author | Md Abdur Rahim Himel Kumar Biswas Md Abdul Kader Zilani Rama Biswas Sirazul Haque Ershad |
| author_facet | Md Abdur Rahim Himel Kumar Biswas Md Abdul Kader Zilani Rama Biswas Sirazul Haque Ershad |
| author_sort | Md Abdur Rahim |
| collection | DOAJ |
| description | ABSTRACT Multiple drug resistance to Acinetobacter baumannii infection treatment is a great challenge for neuro‐intensivists due to poor drug penetration through the blood–brain barrier (BBB). Fortunately, the intraventricular administration of polymyxin‐B and tigecycline seems to be effective; there are few case reports demonstrating the effectiveness of such treatments. Here, we report the case of a 24‐year‐old male who presented with fever and neck rigidity after intracranial drainage following lung infection caused by MDR Acinetobacter baumannii. Due to the presence of turbid CSF, the administration of the intrathecal (ITH) route polymyxin‐B and tigecycline is not possible. In this situation, the neuro‐intensivist decided to start intraventricular tigecycline and polymyxin‐B administration along with IV tigecycline and polymyxin‐B via the intraventricular route, which was feasible because the patient had an external ventricular drain (EVD) due to obstructive hydrocephalus caused by the neurosurgeon after excision of the tumor. |
| format | Article |
| id | doaj-art-85fab449de5b4e10ba33673f52e2dce5 |
| institution | Kabale University |
| issn | 2050-0904 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj-art-85fab449de5b4e10ba33673f52e2dce52024-11-25T12:48:38ZengWileyClinical Case Reports2050-09042024-11-011211n/an/a10.1002/ccr3.9559Successful Treatment of MDR Acinetobacter baumannii Meningitis in a Young Adult Patient With Intraventricular and Intravenous Polymyxin B‐Tigecycline Based Combinations: A Case ReportMd Abdur Rahim0Himel Kumar Biswas1Md Abdul Kader Zilani2Rama Biswas3Sirazul Haque Ershad4Department of Neuro‐ICU Square Hospitals Ltd. Dhaka BangladeshDepartment of Neurology Square Hospitals Ltd. Dhaka BangladeshDepartment of Neuro‐ICU Square Hospitals Ltd. Dhaka BangladeshDepartment of Neurology Square Hospitals Ltd. Dhaka BangladeshDepartment of Neurosurgery Square Hospitals Ltd. Dhaka BangladeshABSTRACT Multiple drug resistance to Acinetobacter baumannii infection treatment is a great challenge for neuro‐intensivists due to poor drug penetration through the blood–brain barrier (BBB). Fortunately, the intraventricular administration of polymyxin‐B and tigecycline seems to be effective; there are few case reports demonstrating the effectiveness of such treatments. Here, we report the case of a 24‐year‐old male who presented with fever and neck rigidity after intracranial drainage following lung infection caused by MDR Acinetobacter baumannii. Due to the presence of turbid CSF, the administration of the intrathecal (ITH) route polymyxin‐B and tigecycline is not possible. In this situation, the neuro‐intensivist decided to start intraventricular tigecycline and polymyxin‐B administration along with IV tigecycline and polymyxin‐B via the intraventricular route, which was feasible because the patient had an external ventricular drain (EVD) due to obstructive hydrocephalus caused by the neurosurgeon after excision of the tumor.https://doi.org/10.1002/ccr3.9559intracranial infectionintraventricular injection of polymyxin BMDR Acinetobacter baumanniitigecycline |
| spellingShingle | Md Abdur Rahim Himel Kumar Biswas Md Abdul Kader Zilani Rama Biswas Sirazul Haque Ershad Successful Treatment of MDR Acinetobacter baumannii Meningitis in a Young Adult Patient With Intraventricular and Intravenous Polymyxin B‐Tigecycline Based Combinations: A Case Report Clinical Case Reports intracranial infection intraventricular injection of polymyxin B MDR Acinetobacter baumannii tigecycline |
| title | Successful Treatment of MDR Acinetobacter baumannii Meningitis in a Young Adult Patient With Intraventricular and Intravenous Polymyxin B‐Tigecycline Based Combinations: A Case Report |
| title_full | Successful Treatment of MDR Acinetobacter baumannii Meningitis in a Young Adult Patient With Intraventricular and Intravenous Polymyxin B‐Tigecycline Based Combinations: A Case Report |
| title_fullStr | Successful Treatment of MDR Acinetobacter baumannii Meningitis in a Young Adult Patient With Intraventricular and Intravenous Polymyxin B‐Tigecycline Based Combinations: A Case Report |
| title_full_unstemmed | Successful Treatment of MDR Acinetobacter baumannii Meningitis in a Young Adult Patient With Intraventricular and Intravenous Polymyxin B‐Tigecycline Based Combinations: A Case Report |
| title_short | Successful Treatment of MDR Acinetobacter baumannii Meningitis in a Young Adult Patient With Intraventricular and Intravenous Polymyxin B‐Tigecycline Based Combinations: A Case Report |
| title_sort | successful treatment of mdr acinetobacter baumannii meningitis in a young adult patient with intraventricular and intravenous polymyxin b tigecycline based combinations a case report |
| topic | intracranial infection intraventricular injection of polymyxin B MDR Acinetobacter baumannii tigecycline |
| url | https://doi.org/10.1002/ccr3.9559 |
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