Clinical Applicability of Stem Cell Therapy in Dental Diseases: A Systematic Review of Available Clinical Trials
Background: Developing cell-based therapeutic methods for differentiating various stem cells into dental tissues could be a revolutionary step toward using cell therapy for dental diseases. In the present study, we systematically reviewed the literature to determine the efficiency of stem cells in t...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mazandaran University of Medical Sciences and Health Services
2022-08-01
|
| Series: | Research in Molecular Medicine |
| Subjects: | |
| Online Access: | http://rmm.mazums.ac.ir/article-1-478-en.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849313931371216896 |
|---|---|
| author | Atena Shiva Shahin Arab Maziar Khatami Nika Rezaeikalantari Rezvan Yazdian Parastoo Namdar |
| author_facet | Atena Shiva Shahin Arab Maziar Khatami Nika Rezaeikalantari Rezvan Yazdian Parastoo Namdar |
| author_sort | Atena Shiva |
| collection | DOAJ |
| description | Background: Developing cell-based therapeutic methods for differentiating various stem cells into dental tissues could be a revolutionary step toward using cell therapy for dental diseases. In the present study, we systematically reviewed the literature to determine the efficiency of stem cells in treating various dental diseases.
Methods: Using the search words “stem cell” and “dental disease” as well as all their equivalents and similar terms, we performed a literature search in September 2020 in the electronic databases: PubMed, Scopus, Science Direct, Web of Science, Embase, Ovid, and Google Scholar. The investigation was limited to clinical trials written in the English language.
Results: Overall, 22 articles with 400 study patients were found and used for qualitative data synthesis. Findings showed that various stem cells with different origins can be used for cell therapy of various dental diseases such as pulp necrosis, traumatic dental injuries, maxillofacial bony defects, impacted third molars, etc.
Conclusion: Stem cell therapy is an efficient method for treating dental diseases. It can regenerate whole dental pulp and may be useful for treating tooth injuries due to trauma. |
| format | Article |
| id | doaj-art-85f2f811ae3e44e7bd8652833d8efaba |
| institution | Kabale University |
| issn | 2322-1348 2322-133X |
| language | English |
| publishDate | 2022-08-01 |
| publisher | Mazandaran University of Medical Sciences and Health Services |
| record_format | Article |
| series | Research in Molecular Medicine |
| spelling | doaj-art-85f2f811ae3e44e7bd8652833d8efaba2025-08-20T03:52:38ZengMazandaran University of Medical Sciences and Health ServicesResearch in Molecular Medicine2322-13482322-133X2022-08-01103115124Clinical Applicability of Stem Cell Therapy in Dental Diseases: A Systematic Review of Available Clinical TrialsAtena Shiva0Shahin Arab1Maziar Khatami2Nika Rezaeikalantari3Rezvan Yazdian4Parastoo Namdar5 Associate Professor, Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Dental Research Center, Mazandaran University of Medical Sciences, Sari, Iran PhD in Clinical Biochemistry, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran .Department of Periodontics,Dental Research Center,Faculty of Dentistry,Mazandaran University of Medical Sciences,Sari,Iran Dental Research Center, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran Department of Molecular and Cell Biology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Department of Orthodontics, Dental Research Center, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran Background: Developing cell-based therapeutic methods for differentiating various stem cells into dental tissues could be a revolutionary step toward using cell therapy for dental diseases. In the present study, we systematically reviewed the literature to determine the efficiency of stem cells in treating various dental diseases. Methods: Using the search words “stem cell” and “dental disease” as well as all their equivalents and similar terms, we performed a literature search in September 2020 in the electronic databases: PubMed, Scopus, Science Direct, Web of Science, Embase, Ovid, and Google Scholar. The investigation was limited to clinical trials written in the English language. Results: Overall, 22 articles with 400 study patients were found and used for qualitative data synthesis. Findings showed that various stem cells with different origins can be used for cell therapy of various dental diseases such as pulp necrosis, traumatic dental injuries, maxillofacial bony defects, impacted third molars, etc. Conclusion: Stem cell therapy is an efficient method for treating dental diseases. It can regenerate whole dental pulp and may be useful for treating tooth injuries due to trauma.http://rmm.mazums.ac.ir/article-1-478-en.pdfstem cellbone regenerationdental diseasedifferentiationregeneration |
| spellingShingle | Atena Shiva Shahin Arab Maziar Khatami Nika Rezaeikalantari Rezvan Yazdian Parastoo Namdar Clinical Applicability of Stem Cell Therapy in Dental Diseases: A Systematic Review of Available Clinical Trials Research in Molecular Medicine stem cell bone regeneration dental disease differentiation regeneration |
| title | Clinical Applicability of Stem Cell Therapy in Dental Diseases: A Systematic Review of Available Clinical Trials |
| title_full | Clinical Applicability of Stem Cell Therapy in Dental Diseases: A Systematic Review of Available Clinical Trials |
| title_fullStr | Clinical Applicability of Stem Cell Therapy in Dental Diseases: A Systematic Review of Available Clinical Trials |
| title_full_unstemmed | Clinical Applicability of Stem Cell Therapy in Dental Diseases: A Systematic Review of Available Clinical Trials |
| title_short | Clinical Applicability of Stem Cell Therapy in Dental Diseases: A Systematic Review of Available Clinical Trials |
| title_sort | clinical applicability of stem cell therapy in dental diseases a systematic review of available clinical trials |
| topic | stem cell bone regeneration dental disease differentiation regeneration |
| url | http://rmm.mazums.ac.ir/article-1-478-en.pdf |
| work_keys_str_mv | AT atenashiva clinicalapplicabilityofstemcelltherapyindentaldiseasesasystematicreviewofavailableclinicaltrials AT shahinarab clinicalapplicabilityofstemcelltherapyindentaldiseasesasystematicreviewofavailableclinicaltrials AT maziarkhatami clinicalapplicabilityofstemcelltherapyindentaldiseasesasystematicreviewofavailableclinicaltrials AT nikarezaeikalantari clinicalapplicabilityofstemcelltherapyindentaldiseasesasystematicreviewofavailableclinicaltrials AT rezvanyazdian clinicalapplicabilityofstemcelltherapyindentaldiseasesasystematicreviewofavailableclinicaltrials AT parastoonamdar clinicalapplicabilityofstemcelltherapyindentaldiseasesasystematicreviewofavailableclinicaltrials |