Elevated CD4⁺/CD8⁺ ratio and D-dimer as diagnostic biomarkers for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis versus infectious mononucleosis in children: a retrospective case-control study

Elevated CD4⁺/CD8⁺ ratio and D-dimer as diagnostic biomarkers for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis versus infectious mononucleosis in children: a retrospective case-control study

Abstract Objective To identify potential diagnostic biomarkers distinguishing Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) from infectious mononucleosis (EBV-IM) in pediatric patients using a retrospective case-control design. Methods This study enrolled a total of 160...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yun Cheng, Wenjia Tong, Wangqiang Li, Yuanyuan Duan, Jingjing Jin, Biquan Chen
Format:	Article
Language:	English
Published:	BMC 2025-08-01
Series:	BMC Infectious Diseases
Subjects:	Epstein-Barr virus infections Lymphohistiocytosis Hemophagocytic Infectious mononucleosis D-dimer CD4⁺/CD8⁺ ratio
Online Access:	https://doi.org/10.1186/s12879-025-11440-1
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Case Report: Uncommon presentation of Ewing sarcoma complicated by hemophagocytic lymphohistiocytosis: a diagnostic dilemma and therapeutic challenge
by: Zhuan Zou, et al.
Published: (2025-08-01)

Seasonality of infection caused by Epstein – Barr virus
by: T. V. Solomay, et al.
Published: (2020-10-01)

Retrospective analysis of ruxolitinib as induction treatment in pediatric hemophagocytic lymphohistiocytosis
by: Shu-yi Guo, et al.
Published: (2025-12-01)

Familial hemophagocytic lymphohistiocytosis in an infant: A case report
by: Sushma Belurkar, et al.
Published: (2025-01-01)

Kidney Dysfunction and Pathology in the Setting of Hemophagocytic Lymphohistiocytosis
by: Miroslav Sekulic, et al.
Published: (2024-02-01)

Undiagnosed tuberculosis associated with hemophagocytic lymphohistiocytosis due to improper use of corticosteroid
by: Hadi Allahverdi Nazhand, et al.
Published: (2023-11-01)

Adult-Onset Still's Disease Masquerading as Hemophagocytic Lymphohistiocytosis
by: Pooja Gautam, et al.
Published: (2021-07-01)

The PD-1/PD-L1 pathway and Epstein–Barr virus
by: Hui Wang, et al.
Published: (2025-06-01)

DEP regimen for the treatment of hemophagocytic lymphohistiocytosis: a review of published experience
by: Guangqiang Meng, et al.
Published: (2025-06-01)

Development of an early mortality risk prediction model for pediatric patients with secondary hemophagocytic lymphohistiocytosis
by: Nandu Luo, et al.
Published: (2025-07-01)

Optic disc vasculitis secondary to mononucleosis: a case report
by: N. A. Voroshilova, et al.
Published: (2024-10-01)

Etiologies and long-term outcome of pediatric hemophagocytic lymphohistiocytosis and macrophage activation syndrome in Taiwan: a single-center retrospective study
by: Ching-Yu Wang, et al.
Published: (2025-07-01)

A clinical case of a rare complication of infectious mononucleosis associated with the Epstein-Barr virus
by: I. A. Otmakhova, et al.
Published: (2024-07-01)

Ocular inflammation as the first presenting feature of PRF1-associated familial hemophagocytic lymphohistiocytosis, case report and review of literature
by: Asma K. Alzuabi, et al.
Published: (2025-07-01)

Case Report: FAS spontaneous mutation in a familial hemophagocytic lymphohistiocytosis patient with a complex heterozygous mutation in PRF1
by: Wenwen Ding, et al.
Published: (2025-08-01)

Lactic acidosis in hemophagocytic syndrome: diagnostic and therapeutic challenges in the intensive care unit—a case series
by: Tianqi Xu, et al.
Published: (2025-08-01)

The Role of Epstein-Barr Virus in the Pathogenesis of Autoimmune Diseases
by: Natalia Morawiec, et al.
Published: (2025-06-01)

Hemophagocytic Lymphohistiocytosis after ChAdOx1 nCoV-19 Coronavirus Vaccination in a Patient with no Known Comorbidities
by: Nitin Rai, et al.
Published: (2022-10-01)

The effectiveness of etoposide-containing chemotherapy regimens in the initial treatment of Hemophagocytic Syndrome in pregnancy
by: Jie Wang, et al.
Published: (2025-12-01)

Family hemophagocytic lymphohistiocytosis: (2 clinical cases in one family)
by: N. A. Efremova, et al.
Published: (2019-10-01)

Comparative evaluation of the effectiveness of immunomodulatory therapy for infectious mononucleosis of mixed etiology (Epstein Barr and cytomegalovirus) in children
by: E. S. Gasilina, et al.
Published: (2020-06-01)

Cytomegalovirus and Epstein-Barr virus infections among Jordanians: seroprevalence and associated factors
by: Hassan M. Kofahi, et al.
Published: (2025-05-01)

AGE DIFFERENCES OF THE EРSHTEIN – BARR VIRUS INFECTIOUS MONONUCLEOSIS
by: A. L. Bondarenko, et al.
Published: (2018-04-01)

CLINICAL-IMMUNOLOGY EFFICIENCY OF CONSERVATIVE TREATMENT OF PATIENTS WITH CHRONIC TONSILLITIS ASSOCIATED WITH EPSTEIN - BARR VIRUS INFECTION
by: A. S. Krasnitskaja, et al.
Published: (2012-05-01)

serologic markers of Epstein-Barr virus reactivation in the conditions of viral encephalitis in young patients
by: O. V. Goleva, et al.
Published: (2015-04-01)

A case of Epstein Barr virus-associated primary squamous cell carcinoma of stomach
by: Yuki Katsura, et al.
Published: (2021-11-01)

Histone variant H2A.Z cooperates with EBNA1 to maintain Epstein-Barr virus latent epigenome
by: Leonardo Josué Castro-Muñoz, et al.
Published: (2025-08-01)

Clinical and genetic features of UNC13D deficiency with hypogammaglobulinemia
by: Linyan Xiong, et al.
Published: (2025-08-01)

Histopathological characteristics of Epstein-Barr virus (EBV)–associated encephalitis and colitis in chronic active EBV infection
by: Betty A Kasimo, et al.
Published: (2025-05-01)

Epstein-Barr virus in Adygeans and Slavs in Russia: virus types, <i>LMP1</i> variants, and malignant tumors
by: K. V. Smirnova, et al.
Published: (2022-10-01)

About features clinical acute Epstein-Barr virus infection in children syndrome undifferentiated Connective tissue dysplasia
by: S. N. Orlova, et al.
Published: (2014-09-01)

Comparison between ELISA and PCR for Detection of Epstein - Barr virus in children with acute cervical lymphadenitis
by: Nazim Khan, et al.
Published: (2024-11-01)

Cytotoxic Lesions of the Corpus Callosum (CLOCCs) in a Patient with Epstein–Barr Infection: A Case Report and Literature Review
by: Ilona Kopyta, et al.
Published: (2025-02-01)

A case of coexistence of hydroa vacciniforme-like lymphoproliferative disorder and Epstein-Barr virus pneumonia
by: Wei Zhang, MD, PhD, et al.
Published: (2025-09-01)

Diagnostic criteria for Epstein-barr virus-associated encephalitis: a comment on Liu et al
by: Fereshte Sheybani, et al.
Published: (2025-07-01)

The role of cycloferon in the treatment of chronic Helicobacter pyloriinduced gastritis with gastric erosions associated with Epstein – Barr virus
by: T. E. Afanasenkova, et al.
Published: (2022-02-01)

Anti-EBV: Artificial intelligence driven predictive modeling for repurposing drugs as potential antivirals against Epstein-Barr virus
by: Hiteshi Vaidya, et al.
Published: (2025-01-01)

In Silico Analysis of Dysregulated Genes and Drug Resistance in Epstein-Barr Virus Associated Gastric Cancer
by: Tabassom Sedaghat Anbouhi, et al.
Published: (2023-11-01)

Pathogenesis of formation of frequent respiratory infections in children with Epstein-Barr virus and cytomegalovirus infection
by: I. V. Babachenko, et al.
Published: (2014-09-01)

New approaches to the therapy of infectious mononucleosis
by: Yu. G. Pritulina, et al.
Published: (2021-06-01)