Targeted photodynamic therapy technique of Janus nanoparticles on breast cancer
Spherical gold/polyacrylic acid (Au/PAA) polymer–inorganic Janus nanoparticles (JNPs) with simultaneous therapeutic and targeting functions were fabricated. The obtained Au/PAA JNPs were further selectively functionalized with folic acid (FA) and thiol PEG amine (SH-PEG-NH2) on Au sides to provide s...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Artificial Cells, Nanomedicine, and Biotechnology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21691401.2024.2347369 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846139344715251712 |
|---|---|
| author | Hanieh Montaseri Heidi Abrahamse |
| author_facet | Hanieh Montaseri Heidi Abrahamse |
| author_sort | Hanieh Montaseri |
| collection | DOAJ |
| description | Spherical gold/polyacrylic acid (Au/PAA) polymer–inorganic Janus nanoparticles (JNPs) with simultaneous therapeutic and targeting functions were fabricated. The obtained Au/PAA JNPs were further selectively functionalized with folic acid (FA) and thiol PEG amine (SH-PEG-NH2) on Au sides to provide superior biocompatibility and active targeting, while the other PAA sides were loaded with 5-aminolevulinic acid (5-ALA) to serve as a photosensitizer (PS) for photodynamic therapeutic (PDT) effects on MCF-7 cancer cells. The PS loading of 5-ALA was found to be 83% with an average hydrodynamic size and z-potential of 146 ± 0.8 nm and −6.40 mV respectively for FA-Au/PAA-ALA JNPs. The in vitro PDT study of the JNPs on MCF-7 breast cancer cells under 636 nm laser irradiation indicated the cell viability of 24.7% ± 0.5 for FA-Au/PAA-ALA JNPs at the IC50 value of 0.125 mM. In this regard, the actively targeted FA-Au/PAA-ALA JNPs treatment holds great potential for tumour therapy with high cancer cell-killing efficacy. |
| format | Article |
| id | doaj-art-85e7acdb01aa48fa83f3d334895eeaf0 |
| institution | Kabale University |
| issn | 2169-1401 2169-141X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Artificial Cells, Nanomedicine, and Biotechnology |
| spelling | doaj-art-85e7acdb01aa48fa83f3d334895eeaf02024-12-06T10:48:00ZengTaylor & Francis GroupArtificial Cells, Nanomedicine, and Biotechnology2169-14012169-141X2024-12-0152127027710.1080/21691401.2024.2347369Targeted photodynamic therapy technique of Janus nanoparticles on breast cancerHanieh Montaseri0Heidi Abrahamse1Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, Doornfontein, South AfricaLaser Research Centre, Faculty of Health Sciences, University of Johannesburg, Doornfontein, South AfricaSpherical gold/polyacrylic acid (Au/PAA) polymer–inorganic Janus nanoparticles (JNPs) with simultaneous therapeutic and targeting functions were fabricated. The obtained Au/PAA JNPs were further selectively functionalized with folic acid (FA) and thiol PEG amine (SH-PEG-NH2) on Au sides to provide superior biocompatibility and active targeting, while the other PAA sides were loaded with 5-aminolevulinic acid (5-ALA) to serve as a photosensitizer (PS) for photodynamic therapeutic (PDT) effects on MCF-7 cancer cells. The PS loading of 5-ALA was found to be 83% with an average hydrodynamic size and z-potential of 146 ± 0.8 nm and −6.40 mV respectively for FA-Au/PAA-ALA JNPs. The in vitro PDT study of the JNPs on MCF-7 breast cancer cells under 636 nm laser irradiation indicated the cell viability of 24.7% ± 0.5 for FA-Au/PAA-ALA JNPs at the IC50 value of 0.125 mM. In this regard, the actively targeted FA-Au/PAA-ALA JNPs treatment holds great potential for tumour therapy with high cancer cell-killing efficacy.https://www.tandfonline.com/doi/10.1080/21691401.2024.2347369Janus nanoparticlesphotodynamic therapybreast canceractive targeting |
| spellingShingle | Hanieh Montaseri Heidi Abrahamse Targeted photodynamic therapy technique of Janus nanoparticles on breast cancer Artificial Cells, Nanomedicine, and Biotechnology Janus nanoparticles photodynamic therapy breast cancer active targeting |
| title | Targeted photodynamic therapy technique of Janus nanoparticles on breast cancer |
| title_full | Targeted photodynamic therapy technique of Janus nanoparticles on breast cancer |
| title_fullStr | Targeted photodynamic therapy technique of Janus nanoparticles on breast cancer |
| title_full_unstemmed | Targeted photodynamic therapy technique of Janus nanoparticles on breast cancer |
| title_short | Targeted photodynamic therapy technique of Janus nanoparticles on breast cancer |
| title_sort | targeted photodynamic therapy technique of janus nanoparticles on breast cancer |
| topic | Janus nanoparticles photodynamic therapy breast cancer active targeting |
| url | https://www.tandfonline.com/doi/10.1080/21691401.2024.2347369 |
| work_keys_str_mv | AT haniehmontaseri targetedphotodynamictherapytechniqueofjanusnanoparticlesonbreastcancer AT heidiabrahamse targetedphotodynamictherapytechniqueofjanusnanoparticlesonbreastcancer |