Two Disaccharide-Bearing Polyethers, K-41B and K-41Bm, Potently Inhibit HIV-1 via Mechanisms Different from That of Their Precursor Polyether, K-41A

Two Disaccharide-Bearing Polyethers, K-41B and K-41Bm, Potently Inhibit HIV-1 via Mechanisms Different from That of Their Precursor Polyether, K-41A

The screening of novel antiviral agents from marine microorganisms is an important strategy for new drug development. Our previous study found that polyether K-41A and its analog K-41Am, derived from a marine Streptomyces strain, exhibit anti-HIV activity by suppressing the activities of HIV-1 rever...

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Main Authors: Jie Liu, Qiuyu Wei, Xin Liu, Jiang Chen, Yujie Zhan, Qinglian Li, Qian Wang, Bingyu Liang, Junjun Jiang, Fengxiang Qin, Zongxiang Yuan, Qiuzhen Qin, Xuehua Li, Yangping Li, Hao Liang, Li Ye, Bo Zhou
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Current Issues in Molecular Biology
Subjects:
HIV-1
antiviral
marine natural products
polyether antibiotics
Online Access:https://www.mdpi.com/1467-3045/46/12/805
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