Renal tubular GSDME protects cisplatin nephrotoxicity by impeding OGT-STAT3-S100A7A axis in male mice

Renal tubular GSDME protects cisplatin nephrotoxicity by impeding OGT-STAT3-S100A7A axis in male mice

Abstract Gasdermin E (GSDME) is known as a key executive protein of pro-inflammatory pyroptosis. However, the function diversity of GSDME needs further investigation. Here, we show that GSDME expression is downregulated in kidney tissues after cisplatin treatment without detectable N-terminal fragme...

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Main Authors: Qingzhou Chen, Pengxiao Sun, Jiaxin Zhou, Tantan Long, An Xiao, Zhuoliang Liu, Shihui Xu, Wenjing Lei, Rui Zhang, Jianwei Tian, Miaomiao Zhou, Zheng Hu, Fengxin Zhu, Jing Nie
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62071-8
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