Primary neurolymphomatosis presenting as foot drop: A rare case report
Neurolymphomatosis (NL) is the direct infiltration of the peripheral nervous system (PNS) by lymphoma cells and represents the least common form of PNS involvement by lymphoma. Clinical presentation is varied, and early diagnosis remains challenging. Nerve biopsy remains the diagnostic gold standard...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Indian Journal of Pathology and Microbiology |
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| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_731_22 |
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| author | Neha Bakshi Vineeta Chand Rajiv Anand Rajan Duggal |
| author_facet | Neha Bakshi Vineeta Chand Rajiv Anand Rajan Duggal |
| author_sort | Neha Bakshi |
| collection | DOAJ |
| description | Neurolymphomatosis (NL) is the direct infiltration of the peripheral nervous system (PNS) by lymphoma cells and represents the least common form of PNS involvement by lymphoma. Clinical presentation is varied, and early diagnosis remains challenging. Nerve biopsy remains the diagnostic gold standard, use of magnetic resonance imaging (MRI) and fluorodeoxyglucose–positron emission tomography (FDG-PET) may help in diagnosis and selecting targets for biopsy. We report an account of an older male patient who presented with subacute onset multifocal neuropathy involving bilateral lower limbs and left foot drop. The patient was initially misdiagnosed as chronic inflammatory demyelinating polyneuropathy; however radiological assessment revealed fusiform thickening of the L5 nerve root and biopsy from the site revealed extensive infiltration by diffuse large B cell type non-Hodgkin lymphoma (NHL). High index of suspicion is vital to ensure correct diagnosis, timely treatment, and to improve patient survival. |
| format | Article |
| id | doaj-art-85957f4b39cc4a03a5aaaf5bf2ab02b5 |
| institution | Kabale University |
| issn | 0377-4929 0974-5130 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj-art-85957f4b39cc4a03a5aaaf5bf2ab02b52025-01-10T10:28:10ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49290974-51302024-12-0167491892010.4103/ijpm.ijpm_731_22Primary neurolymphomatosis presenting as foot drop: A rare case reportNeha BakshiVineeta ChandRajiv AnandRajan DuggalNeurolymphomatosis (NL) is the direct infiltration of the peripheral nervous system (PNS) by lymphoma cells and represents the least common form of PNS involvement by lymphoma. Clinical presentation is varied, and early diagnosis remains challenging. Nerve biopsy remains the diagnostic gold standard, use of magnetic resonance imaging (MRI) and fluorodeoxyglucose–positron emission tomography (FDG-PET) may help in diagnosis and selecting targets for biopsy. We report an account of an older male patient who presented with subacute onset multifocal neuropathy involving bilateral lower limbs and left foot drop. The patient was initially misdiagnosed as chronic inflammatory demyelinating polyneuropathy; however radiological assessment revealed fusiform thickening of the L5 nerve root and biopsy from the site revealed extensive infiltration by diffuse large B cell type non-Hodgkin lymphoma (NHL). High index of suspicion is vital to ensure correct diagnosis, timely treatment, and to improve patient survival.https://journals.lww.com/10.4103/ijpm.ijpm_731_22diagnosislymphomamanagementneuropathyperipheral nervous system |
| spellingShingle | Neha Bakshi Vineeta Chand Rajiv Anand Rajan Duggal Primary neurolymphomatosis presenting as foot drop: A rare case report Indian Journal of Pathology and Microbiology diagnosis lymphoma management neuropathy peripheral nervous system |
| title | Primary neurolymphomatosis presenting as foot drop: A rare case report |
| title_full | Primary neurolymphomatosis presenting as foot drop: A rare case report |
| title_fullStr | Primary neurolymphomatosis presenting as foot drop: A rare case report |
| title_full_unstemmed | Primary neurolymphomatosis presenting as foot drop: A rare case report |
| title_short | Primary neurolymphomatosis presenting as foot drop: A rare case report |
| title_sort | primary neurolymphomatosis presenting as foot drop a rare case report |
| topic | diagnosis lymphoma management neuropathy peripheral nervous system |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_731_22 |
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