Nrf2-dependent effects of CDDO-Me on bactericidal activity in macrophage infection models

Nrf2-dependent effects of CDDO-Me on bactericidal activity in macrophage infection models

IntroductionDiabetes and chronic kidney disease (CKD) increase susceptibility to bacterial infections, particularly Staphylococcus aureus, which is associated with highmortality in CKD patients. Dysregulated macrophage activity and excessive oxidative stress exacerbate immune dysfunction and inflamm...

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Bibliographic Details
Main Authors: Therese B. Deramaudt, Ahmad Chehaitly, Marcel Bonay
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
CDDO-Me
macrophages
inflammation
bronchoalveolar lavage
oxidative stress
bactericidal activity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1574776/full
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