Dimeric dipeptide mimetics of the nerve growth factor loops 3 and 4 are active in a model of ischemic stroke
Pharmacological activity of dimeric dipeptide mimetics of the nerve growth factor loops 3 and 4, correspondingly GTS-115 and GK-2, was studied in a model of ischemic stroke, induced by transient middle cerebral artery occlusion in rats. The both compounds, at i.p. subchronic administration (0,5-1 mg...
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| Format: | Article |
| Language: | Russian |
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LLC “Publisher OKI”
2016-09-01
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| Series: | Фармакокинетика и Фармакодинамика |
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| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/182 |
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| author | P. Y. Povarnina T. A. Gudasheva S. B. Seredenin |
| author_facet | P. Y. Povarnina T. A. Gudasheva S. B. Seredenin |
| author_sort | P. Y. Povarnina |
| collection | DOAJ |
| description | Pharmacological activity of dimeric dipeptide mimetics of the nerve growth factor loops 3 and 4, correspondingly GTS-115 and GK-2, was studied in a model of ischemic stroke, induced by transient middle cerebral artery occlusion in rats. The both compounds, at i.p. subchronic administration (0,5-1 mg/kg/day, 7 days, beginning at 4 hours after surgery), significantly reduced cerebral infarct volume as was estimated by morphometry of 2,3,5-triphenyltetrazolium chloride (TTC) -stained brain slices: GTS-115 by 25% and GK-2 by 35%. Mimetic of NGF loop 4 (GK-2), which is the most active compound, was selected for further development as a potential therapeutic agent. |
| format | Article |
| id | doaj-art-857deff10b2a4e56a7a61a72f0ff8efc |
| institution | Kabale University |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2016-09-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-857deff10b2a4e56a7a61a72f0ff8efc2025-08-20T03:42:31ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302016-09-01033437181Dimeric dipeptide mimetics of the nerve growth factor loops 3 and 4 are active in a model of ischemic strokeP. Y. Povarnina0T. A. Gudasheva1S. B. Seredenin2FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»Pharmacological activity of dimeric dipeptide mimetics of the nerve growth factor loops 3 and 4, correspondingly GTS-115 and GK-2, was studied in a model of ischemic stroke, induced by transient middle cerebral artery occlusion in rats. The both compounds, at i.p. subchronic administration (0,5-1 mg/kg/day, 7 days, beginning at 4 hours after surgery), significantly reduced cerebral infarct volume as was estimated by morphometry of 2,3,5-triphenyltetrazolium chloride (TTC) -stained brain slices: GTS-115 by 25% and GK-2 by 35%. Mimetic of NGF loop 4 (GK-2), which is the most active compound, was selected for further development as a potential therapeutic agent.https://www.pharmacokinetica.ru/jour/article/view/182димерный дипептидный миметикфактор роста нервовнейропротекцияишемический инсультокклюзия средней мозговой артерииdimeric dipeptide mimeticnerve growth factorneuroprotectionischemic strokemiddle cerebral artery occlusion |
| spellingShingle | P. Y. Povarnina T. A. Gudasheva S. B. Seredenin Dimeric dipeptide mimetics of the nerve growth factor loops 3 and 4 are active in a model of ischemic stroke Фармакокинетика и Фармакодинамика димерный дипептидный миметик фактор роста нервов нейропротекция ишемический инсульт окклюзия средней мозговой артерии dimeric dipeptide mimetic nerve growth factor neuroprotection ischemic stroke middle cerebral artery occlusion |
| title | Dimeric dipeptide mimetics of the nerve growth factor loops 3 and 4 are active in a model of ischemic stroke |
| title_full | Dimeric dipeptide mimetics of the nerve growth factor loops 3 and 4 are active in a model of ischemic stroke |
| title_fullStr | Dimeric dipeptide mimetics of the nerve growth factor loops 3 and 4 are active in a model of ischemic stroke |
| title_full_unstemmed | Dimeric dipeptide mimetics of the nerve growth factor loops 3 and 4 are active in a model of ischemic stroke |
| title_short | Dimeric dipeptide mimetics of the nerve growth factor loops 3 and 4 are active in a model of ischemic stroke |
| title_sort | dimeric dipeptide mimetics of the nerve growth factor loops 3 and 4 are active in a model of ischemic stroke |
| topic | димерный дипептидный миметик фактор роста нервов нейропротекция ишемический инсульт окклюзия средней мозговой артерии dimeric dipeptide mimetic nerve growth factor neuroprotection ischemic stroke middle cerebral artery occlusion |
| url | https://www.pharmacokinetica.ru/jour/article/view/182 |
| work_keys_str_mv | AT pypovarnina dimericdipeptidemimeticsofthenervegrowthfactorloops3and4areactiveinamodelofischemicstroke AT tagudasheva dimericdipeptidemimeticsofthenervegrowthfactorloops3and4areactiveinamodelofischemicstroke AT sbseredenin dimericdipeptidemimeticsofthenervegrowthfactorloops3and4areactiveinamodelofischemicstroke |