Epitope-Driven Vaccine Development for Zika Virus: A Bioinformatics Approach
Zika virus (ZIKV) has become a global concern in 2015-2016, which can infect adults and developing fetuses. ZIKV is a member of the Flaviviridae family, which can spread through Aedes mosquitoes, sexual intercourse, from mother to fetus, and blood transfusions. The genetic material is single-strande...
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| Format: | Article |
| Language: | Indonesian |
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Poltekkes Kemenkes Yogyakarta
2024-12-01
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| Series: | Jurnal Teknologi Laboratorium |
| Online Access: | https://teknolabjournal.com/index.php/Jtl/article/view/518 |
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| author | Riska Ayu Sutriyansyah Muhamad Hilmi Ihsanul Iman Cahya Ajeng Valenta Tresna Sulung Nelly Indira Kusuma Wardani Arif Nur Muhammad Ansori |
| author_facet | Riska Ayu Sutriyansyah Muhamad Hilmi Ihsanul Iman Cahya Ajeng Valenta Tresna Sulung Nelly Indira Kusuma Wardani Arif Nur Muhammad Ansori |
| author_sort | Riska Ayu Sutriyansyah |
| collection | DOAJ |
| description | Zika virus (ZIKV) has become a global concern in 2015-2016, which can infect adults and developing fetuses. ZIKV is a member of the Flaviviridae family, which can spread through Aedes mosquitoes, sexual intercourse, from mother to fetus, and blood transfusions. The genetic material is single-stranded RNA with positive polarity. Conventional vaccine development requires a long time and significant resources, so the bioinformatics approach is an efficient alternative for identifying B cell epitopes as vaccine candidates. This research uses bioinformatics or In silico methods to identify B cell epitopes with the immune epitope database (IEDB) web server. This research showed that the peptide sequence of "EWFHDIPLPWHAGADTGTPHWNNKEA" (peptide 6E) in the envelope protein E of ZIKV is a potential vaccine candidate. This peptide is predicted to have high antigenicity, non-allergenicity and non-toxicity. This study concluded that peptide 6E is a promising vaccine candidate. Further studies are needed in vitro and in vivo to reconfirm that it can be used as a potential ZIKV vaccine candidate and can be applied in the future. |
| format | Article |
| id | doaj-art-855323c921b64146b97c82c59d6fc9e4 |
| institution | Kabale University |
| issn | 2338-5634 2580-0191 |
| language | Indonesian |
| publishDate | 2024-12-01 |
| publisher | Poltekkes Kemenkes Yogyakarta |
| record_format | Article |
| series | Jurnal Teknologi Laboratorium |
| spelling | doaj-art-855323c921b64146b97c82c59d6fc9e42025-01-03T15:40:12ZindPoltekkes Kemenkes YogyakartaJurnal Teknologi Laboratorium2338-56342580-01912024-12-011329610510.29238/teknolabjournal.v13i2.518470Epitope-Driven Vaccine Development for Zika Virus: A Bioinformatics ApproachRiska Ayu Sutriyansyah0Muhamad Hilmi Ihsanul Iman1Cahya Ajeng Valenta Tresna Sulung2Nelly Indira Kusuma Wardani3Arif Nur Muhammad Ansori4https://orcid.org/0000-0002-1279-3904Study Program of Biology, Faculty of Mathematics and Natural Sciences, Surabaya State University, Surabaya, IndonesiaStudy Program of Biology, Faculty of Mathematics and Natural Sciences, Surabaya State University, Surabaya, IndonesiaStudy Program of Biology, Faculty of Mathematics and Natural Sciences, Surabaya State University, Surabaya, IndonesiaStudy Program of Biology, Faculty of Mathematics and Natural Sciences, Surabaya State University, Surabaya, IndonesiaUniversitas AirlanggaZika virus (ZIKV) has become a global concern in 2015-2016, which can infect adults and developing fetuses. ZIKV is a member of the Flaviviridae family, which can spread through Aedes mosquitoes, sexual intercourse, from mother to fetus, and blood transfusions. The genetic material is single-stranded RNA with positive polarity. Conventional vaccine development requires a long time and significant resources, so the bioinformatics approach is an efficient alternative for identifying B cell epitopes as vaccine candidates. This research uses bioinformatics or In silico methods to identify B cell epitopes with the immune epitope database (IEDB) web server. This research showed that the peptide sequence of "EWFHDIPLPWHAGADTGTPHWNNKEA" (peptide 6E) in the envelope protein E of ZIKV is a potential vaccine candidate. This peptide is predicted to have high antigenicity, non-allergenicity and non-toxicity. This study concluded that peptide 6E is a promising vaccine candidate. Further studies are needed in vitro and in vivo to reconfirm that it can be used as a potential ZIKV vaccine candidate and can be applied in the future.https://teknolabjournal.com/index.php/Jtl/article/view/518 |
| spellingShingle | Riska Ayu Sutriyansyah Muhamad Hilmi Ihsanul Iman Cahya Ajeng Valenta Tresna Sulung Nelly Indira Kusuma Wardani Arif Nur Muhammad Ansori Epitope-Driven Vaccine Development for Zika Virus: A Bioinformatics Approach Jurnal Teknologi Laboratorium |
| title | Epitope-Driven Vaccine Development for Zika Virus: A Bioinformatics Approach |
| title_full | Epitope-Driven Vaccine Development for Zika Virus: A Bioinformatics Approach |
| title_fullStr | Epitope-Driven Vaccine Development for Zika Virus: A Bioinformatics Approach |
| title_full_unstemmed | Epitope-Driven Vaccine Development for Zika Virus: A Bioinformatics Approach |
| title_short | Epitope-Driven Vaccine Development for Zika Virus: A Bioinformatics Approach |
| title_sort | epitope driven vaccine development for zika virus a bioinformatics approach |
| url | https://teknolabjournal.com/index.php/Jtl/article/view/518 |
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