Click Synthesis and Biologic Evaluation of ()- and ()-2-Amino-3-[1-(2-[F]Fluoroethyl)-1-[1,2,3]Triazol-4-yl]Propanoic Acid for Brain Tumor Imaging with Positron Emission Tomography

Click Synthesis and Biologic Evaluation of ()- and ()-2-Amino-3-[1-(2-[F]Fluoroethyl)-1-[1,2,3]Triazol-4-yl]Propanoic Acid for Brain Tumor Imaging with Positron Emission Tomography

The ( R )- and ( S )-enantiomers of 2-amino-3-[1-(2-[ 18 F]fluoroethyl)-1 H -[1,2,3]triazol-4-yl]propanoic acid (4) were synthesized and evaluated in the rat 9L gliosarcoma brain tumor model using cell uptake assays, biodistribution studies, and micro-positron emission tomography (microPET). The ( R...

Full description

Saved in:

Bibliographic Details
Main Authors:	Jonathan McConathy, Dong Zhou, Stephany E. Shockley, Lynne A. Jones, Elizabeth A. Griffin, Hsiaoju Lee, Susan J. Adams, Robert H. Mach
Format:	Article
Language:	English
Published:	SAGE Publishing 2010-11-01
Series:	Molecular Imaging
Online Access:	https://doi.org/10.2310/7290.2010.00025
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Green ultrasound-assisted three-component click synthesis of novel 1H-1,2,3-triazole carrying benzothiazoles and fluorinated-1,2,4-triazole conjugates and their antimicrobial evaluation
by: Rezki Nadjet, et al.
Published: (2017-09-01)

Binary solvent participation in crystals of a multi-aromatic 1,2,3-triazole
by: Jonathan Filley
Published: (2025-01-01)

Synthesis and Anti-Inflammatory Activity of New Alkyl-Substituted Phthalimide 1H-1,2,3-Triazole Derivatives
by: Shalom Pôrto de Oliveira Assis, et al.
Published: (2012-01-01)

Synthesis of some benzimidazole derivatives endowed with 1,2,3-triazole as potential inhibitors of hepatitis C virus
by: Youssif Bahaa G. M., et al.
Published: (2016-06-01)

Design, synthesis, and apoptotic antiproliferative action of new benzimidazole/1,2,3-triazole hybrids as EGFR inhibitors
by: Alshimaa A. Y. Ahmed, et al.
Published: (2025-01-01)

Microwave-Assisted Regioselective Synthesis and 2D-NMR Studies of New 1,2,3-Triazole Compounds Derived from Acridone
by: Mohammed Aarjane, et al.
Published: (2021-01-01)

Design, Synthesis, enzyme inhibitory activity and molecular docking studies of new 1,2,3-triazole linked nucleobases
by: Aditya Aggarwal, et al.
Published: (2025-01-01)

Design, synthesis, and anti-inflammatory activity of 2H-1,4-benzoxazin-3(4H)-one derivatives modified with 1,2,3-triazole in LPS-induced BV-2 cells
by: Xixi Hou, et al.
Published: (2025-01-01)

Anti-cancer activity of synthetic gefitinib-1,2,3-triazole derivatives against Hela cells via induction of apoptosis
by: Zhihong Hu, et al.
Published: (2025-01-01)

The crystal structure of 4,5-diiodo-1,3-dimesityl-1H-1,2,3-triazol-3-ium hexafluoridoantimonate(V), C20H22F6I2N3Sb
by: Xu Xingyu, et al.
Published: (2021-09-01)

Fe3O4@HA-Cu(OAc)2 nanocomposite as a nanomagnetic water-compatible catalyst for efficient synthesis of 1,2,3-triazoles in water
by: Beheshteh Arjmandzadeh, et al.
Published: (2025-01-01)

Novel coumarin-based acetohydrazide-1,2,3-triazole derivatives as urease enzyme inhibitors: Synthesis, in vitro evaluation, and molecular dynamics simulation studies
by: Hassan Sepehrmansourie, et al.
Published: (2025-01-01)

A Novel Synthesis of 1,2,3-Benzotriazinones from 2-(o-Aminophenyl)oxazolines
by: Fernando Rocha-Alonzo, et al.
Published: (2017-01-01)

Ligand Synthesis Catalyst and Complex Metal Ion: Multicomponent Synthesis of 1,3-Bis(4-phenyl-[1,2,3]triazol-1-yl)-propan-2-ol Copper(I) Complex and Application in Copper-Catalyzed Alkyne-Azide Cycloaddition
by: María Teresa Ramírez-Palma, et al.
Published: (2016-01-01)

A Recent Overview of 1,2,3-Triazole-Containing Hybrids as Novel Antifungal Agents: Focusing on Synthesis, Mechanism of Action, and Structure-Activity Relationship (SAR)
by: Mahrokh Marzi, et al.
Published: (2022-01-01)

Crystal structure of diaqua-bis[5-methyl-1-(1H-pyrazol-3-yl)-1H-1,2,3-triazole-4-carboxylato-κ 2 N,O)]manganese(II), C14H16MnN10O6
by: Guo Jing-Jing, et al.
Published: (2025-02-01)

Design and development of novel 1,2,3-triazole chalcone derivatives as potential anti-osteosarcoma agents via inhibition of PI3K/Akt/mTOR signalling pathway
by: Su Qing, et al.
Published: (2022-09-01)

Crystal structure of methyl 3-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)propanoate, C16H13NO4
by: Wang Tiantian, et al.
Published: (2022-08-01)

Thermodynamic Studies of [M+2] Complexes with 3-Hydroxy-2-(3-(4-Nitrobenzoyl) Thiouriedo) Propanoic Acid
by: Basima M. Sarhan, et al.
Published: (2025-01-01)

Synthesis and Antimicrobial Activities of 1,2,4-Triazole and 1,3,4-Thiadiazole Derivatives of 5-Amino-2-Hydroxybenzoic Acid
by: Sabir Hussain, et al.
Published: (2008-01-01)

Synthesis and Antibacterial Activity of Some Derivatives of 2-Methylbenzimidazole Containing 1,3,4-Oxadiazole or 1,2,4-Triazole Heterocycle
by: Cong Nguyen Tien, et al.
Published: (2016-01-01)

Synthesis and Characterization of Mono- and Bicycle Heterocyclic Derivatives Containing 1, 2,4-Triazole, 1,3,4-Thiadiazine and 1,3-Thiazole Rings
by: Navabeh Nami, et al.
Published: (2012-01-01)

In Vivo Evaluation of 1-O-(4-(2-Fluoroethyl-Carbamoyloxymethyl)-2-Nitrophenyl)-O-β-D-Glucopyronuronate: A Positron Emission Tomographic Tracer for Imaging β-Glucuronidase Activity in a Tumor/Inflammation Rodent Model
by: Iněs F. Antunes, et al.
Published: (2012-01-01)

In Vivo Evaluation of 1-O-(4-(2-Fluoroethyl-Carbamoyloxymethyl)-2-Nitrophenyl)-O-β-D-Glucopyronuronate: A Positron Emission Tomographic Tracer for Imaging β-Glucuronidase Activity in a Tumor/Inflammation Rodent Model
by: Iněs F. Antunes, et al.
Published: (2012-01-01)

Classification of Stages 1,2,3 and Preplus, Plus disease of ROP using MultiCNN_LSTM classifier
by: Ranjana Agrawal, et al.
Published: (2025-06-01)

Crystal structure of 3-phenylpropyl 2-(6-methoxynaphthalen-2-yl)propanoate, C23H24O3
by: Wang Li-li, et al.
Published: (2022-08-01)

Gadolinium(III) Ion-Selective Electrode Based on 3-Methyl-1H-1,2,4-triazole-5-thiol
by: Hassan Ali Zamani, et al.
Published: (2012-01-01)

Synthesis, Evaluation and Characterization of Some 1,3,4-Triazole-2-one Derivatives as Antimicrobial Agents
by: Mahabaleshwaraiah Neelgundmath, et al.
Published: (2012-01-01)

Preparation and Antibacterial Properties of Substituted 1,2,4-Triazoles
by: Ionuţ Ledeţi, et al.
Published: (2015-01-01)

The crystal structure of bis[μ2-(3-(3-(pyridin-2-yl)-1H-pyrazol-1-yl)propanoate-κ2O:N)-bis(2,2′-bipyridine-κ2 N, N′)dicopper(II)]dinitrate, C42H36Cu2N12O10
by: Tang Zhiwei, et al.
Published: (2025-02-01)

Crystal structure of catena-[(μ3-bromido)-(1H-1,2,4-triazol-1-yl)benzoato-κ1 N)copper(I)], C9H7BrCuN3O2
by: Yuan Zhi-Min, et al.
Published: (2023-08-01)

In vitro Biological Evaluation of 1,2,4-triazole Mannich Base
by: Mahmood Sherzad Rafaat, et al.
Published: (2023-12-01)

Crystal structure of 1H-1,2,3-Triazolo[4,5-b]-pyridin-4-ium nitrate, C5H5N5O3
by: Zhou Meng-Shu, et al.
Published: (2022-08-01)

The crystal structure of 2,2-bis(3-methoxyphenyl)-1-tosyl-1,2-dihydro- 2λ4,3λ4 -[1,3,2]diazaborolo[4,5,1-ij]quinoline - dichloromethane (1/1)
by: Ding Siyi
Published: (2023-08-01)

Crystal structure of 3-methoxybenzyl 2-(6-methoxynaphthalen-2-yl)propanoate, C22H22O4
by: Sun Quan-Le, et al.
Published: (2025-02-01)

Synthesis, Characterisation, Theoretical NMR Calculations and Crystal Structure of the 3-methyl-1H-1,2,4?4-triazole-5-amine acetate
by: Patricia Saraiva Vilas Boas Almeida, et al.
Published: (2022-09-01)

Synthesis and Antioxidant Evaluation of Enantiomerically Pure Bis-(1,2,3-triazolylmethyl)amino Esters from Modified α-Amino Acids
by: Juan I. Sarmiento-Sánchez, et al.
Published: (2014-01-01)

Novel Syntheses of Some 1, 2, 4-Triazoles as Potent Bacteriocidal Agents
by: Ram Janam Singh, et al.
Published: (2010-01-01)

Синтез и идентификация 1,1,3,3-тетра-[1,2-дигидро1,5-диметил-2-фенил-3-оксопиразол]пропана
by: Д.В. Бабадеев*, Е.А. Строганова
Published: (2020-10-01)

Electric Modulus Analysis of (1 − x) PbMg1/3Nb2/3O3-(x)K1/2Bi1/2TiO3 Ceramics
by: Kebede Legesse, et al.
Published: (2022-01-01)