The Relationship Between System Involvement and Vitamin D Level in Cases Diagnosed with Multisystem Inflammatory Syndrome in Children
Introduction: Vitamin D is a steroid prehormone that is produced in the skin as a result of exposure to UV-B, is fat-soluble and has immunomodulatory properties by affecting immune cells. In this study, it was aimed to evaluate the relationship between systemic involvement and 25-OH vitamin D level...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2024-12-01
|
| Series: | Güncel Pediatri |
| Subjects: | |
| Online Access: | https://www.guncelpediatri.com/articles/the-relationship-between-system-involvement-and-vitamin-d-level-in-cases-diagnosed-with-multisystem-inflammatory-syndrome-in-children/doi/jcp.2024.70593 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846126875560116224 |
|---|---|
| author | Aysun Soyugüzel Ayşegül Bükülmez Ayhan Pektaş İbrahim Eker Mehmet Çeleğen Hilal Koyuncu |
| author_facet | Aysun Soyugüzel Ayşegül Bükülmez Ayhan Pektaş İbrahim Eker Mehmet Çeleğen Hilal Koyuncu |
| author_sort | Aysun Soyugüzel |
| collection | DOAJ |
| description | Introduction: Vitamin D is a steroid prehormone that is produced in the skin as a result of exposure to UV-B, is fat-soluble and has immunomodulatory properties by affecting immune cells. In this study, it was aimed to evaluate the relationship between systemic involvement and 25-OH vitamin D level in patients with a diagnosis of MIS-C.
Materials and Methods: It is a descriptive research. It was conducted at AFSÜ, Health Application and Research Center between 01.10.2020-01.04.2022. Patients aged between 1 month and 18 years who were diagnosed with MIS-C and who applied to AFSU, Child Health and Diseases Clinic, and whose serum 25-OH vitamin D was in the electronic archive system, were included in this study. The collected data were analyzed with the Statistical Package for Social Sciences version 26.0. It was done with the S package program.Since vitamin D was not distributed normally, the Mann-Whitney U test was used when comparing between paired groups. The Kruskal Wallis test was used when comparing vitamin D levels between more than two groups.
Results: This retrospective study was conducted with 34 patients diagnosed MIS-C. The mean age of the cases was 7.03±3.9 years; 52.9% (n=18) were males and 47.1% (n=16) were females. Gastrointestinal system (58.8%; n=20), cardiac (64.7%; n=22) and neurological involvement (23.5%; n=8) were found. Mean 25-OH vitamin D were found to be 15.7 (IQR= 18) ng/mL in gastrointestinal system, 16.8 (IQR=17) ng/mL in cardiac, and 12 (IQR= 8) ng/mL in neurological system involvement. No statistically significant differences were found between systemic involvement of the cases and their 25-OH vitamin D (p values: 0.779, 0.957, 0.144, respectively). A negative correlation was found between 25-OH vitamin D of the cases and their age (r=-0.414; p=0.015). When the relationship between 25-OH vitamin D and fibrinogen in patients diagnosed with MIS-C was evaluated, a negative correlation was also found (r=-0.414; p=0.015).
Conclusion: As a result, mean 25-OH vitamin D levels in cases diagnosed with MIS-C were found to be at an insufficient level. It was suggested that prophylactic vitamin D should be administered in children. In addition, no significant difference was found between system involvement and vitamin D level. |
| format | Article |
| id | doaj-art-84d19a5878bc46b9bd2086cc2f6ebdd4 |
| institution | Kabale University |
| issn | 1304-9054 1308-6308 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Güncel Pediatri |
| spelling | doaj-art-84d19a5878bc46b9bd2086cc2f6ebdd42024-12-12T07:59:43ZengGalenos Publishing HouseGüncel Pediatri1304-90541308-63082024-12-0122318619610.4274/jcp.2024.70593The Relationship Between System Involvement and Vitamin D Level in Cases Diagnosed with Multisystem Inflammatory Syndrome in ChildrenAysun Soyugüzel0https://orcid.org/0000-0001-8356-1476Ayşegül Bükülmez1https://orcid.org/0000-0002-6013-5172Ayhan Pektaş2https://orcid.org/0000-0002-3238-0752İbrahim Eker3https://orcid.org/0000-0002-1880-546XMehmet Çeleğen4https://orcid.org/0000-0002-6841-3675Hilal Koyuncu5https://orcid.org/0000-0003-1334-071XAfyonkarahisar University of Health Sciences Department of Child Health and Diseases, Afyonkarahisar, TurkeyAfyonkarahisar University of Health Sciences Department of Child Health and Diseases, Afyonkarahisar, TurkeyAfyonkarahisar University of Health Sciences Department of Child Health and Diseases, Afyonkarahisar, TurkeyAfyonkarahisar University of Health Sciences Department of Child Health and Diseases, Afyonkarahisar, TurkeyAfyonkarahisar University of Health Sciences Department of Child Health and Diseases, Afyonkarahisar, TurkeyAfyonkarahisar University of Health Sciences Department of Child Health and Diseases, Afyonkarahisar, TurkeyIntroduction: Vitamin D is a steroid prehormone that is produced in the skin as a result of exposure to UV-B, is fat-soluble and has immunomodulatory properties by affecting immune cells. In this study, it was aimed to evaluate the relationship between systemic involvement and 25-OH vitamin D level in patients with a diagnosis of MIS-C. Materials and Methods: It is a descriptive research. It was conducted at AFSÜ, Health Application and Research Center between 01.10.2020-01.04.2022. Patients aged between 1 month and 18 years who were diagnosed with MIS-C and who applied to AFSU, Child Health and Diseases Clinic, and whose serum 25-OH vitamin D was in the electronic archive system, were included in this study. The collected data were analyzed with the Statistical Package for Social Sciences version 26.0. It was done with the S package program.Since vitamin D was not distributed normally, the Mann-Whitney U test was used when comparing between paired groups. The Kruskal Wallis test was used when comparing vitamin D levels between more than two groups. Results: This retrospective study was conducted with 34 patients diagnosed MIS-C. The mean age of the cases was 7.03±3.9 years; 52.9% (n=18) were males and 47.1% (n=16) were females. Gastrointestinal system (58.8%; n=20), cardiac (64.7%; n=22) and neurological involvement (23.5%; n=8) were found. Mean 25-OH vitamin D were found to be 15.7 (IQR= 18) ng/mL in gastrointestinal system, 16.8 (IQR=17) ng/mL in cardiac, and 12 (IQR= 8) ng/mL in neurological system involvement. No statistically significant differences were found between systemic involvement of the cases and their 25-OH vitamin D (p values: 0.779, 0.957, 0.144, respectively). A negative correlation was found between 25-OH vitamin D of the cases and their age (r=-0.414; p=0.015). When the relationship between 25-OH vitamin D and fibrinogen in patients diagnosed with MIS-C was evaluated, a negative correlation was also found (r=-0.414; p=0.015). Conclusion: As a result, mean 25-OH vitamin D levels in cases diagnosed with MIS-C were found to be at an insufficient level. It was suggested that prophylactic vitamin D should be administered in children. In addition, no significant difference was found between system involvement and vitamin D level.https://www.guncelpediatri.com/articles/the-relationship-between-system-involvement-and-vitamin-d-level-in-cases-diagnosed-with-multisystem-inflammatory-syndrome-in-children/doi/jcp.2024.70593mis-c25-oh vitamin dcovid-19sars-cov-2 |
| spellingShingle | Aysun Soyugüzel Ayşegül Bükülmez Ayhan Pektaş İbrahim Eker Mehmet Çeleğen Hilal Koyuncu The Relationship Between System Involvement and Vitamin D Level in Cases Diagnosed with Multisystem Inflammatory Syndrome in Children Güncel Pediatri mis-c 25-oh vitamin d covid-19 sars-cov-2 |
| title | The Relationship Between System Involvement and Vitamin D Level in Cases Diagnosed with Multisystem Inflammatory Syndrome in Children |
| title_full | The Relationship Between System Involvement and Vitamin D Level in Cases Diagnosed with Multisystem Inflammatory Syndrome in Children |
| title_fullStr | The Relationship Between System Involvement and Vitamin D Level in Cases Diagnosed with Multisystem Inflammatory Syndrome in Children |
| title_full_unstemmed | The Relationship Between System Involvement and Vitamin D Level in Cases Diagnosed with Multisystem Inflammatory Syndrome in Children |
| title_short | The Relationship Between System Involvement and Vitamin D Level in Cases Diagnosed with Multisystem Inflammatory Syndrome in Children |
| title_sort | relationship between system involvement and vitamin d level in cases diagnosed with multisystem inflammatory syndrome in children |
| topic | mis-c 25-oh vitamin d covid-19 sars-cov-2 |
| url | https://www.guncelpediatri.com/articles/the-relationship-between-system-involvement-and-vitamin-d-level-in-cases-diagnosed-with-multisystem-inflammatory-syndrome-in-children/doi/jcp.2024.70593 |
| work_keys_str_mv | AT aysunsoyuguzel therelationshipbetweensysteminvolvementandvitamindlevelincasesdiagnosedwithmultisysteminflammatorysyndromeinchildren AT aysegulbukulmez therelationshipbetweensysteminvolvementandvitamindlevelincasesdiagnosedwithmultisysteminflammatorysyndromeinchildren AT ayhanpektas therelationshipbetweensysteminvolvementandvitamindlevelincasesdiagnosedwithmultisysteminflammatorysyndromeinchildren AT ibrahimeker therelationshipbetweensysteminvolvementandvitamindlevelincasesdiagnosedwithmultisysteminflammatorysyndromeinchildren AT mehmetcelegen therelationshipbetweensysteminvolvementandvitamindlevelincasesdiagnosedwithmultisysteminflammatorysyndromeinchildren AT hilalkoyuncu therelationshipbetweensysteminvolvementandvitamindlevelincasesdiagnosedwithmultisysteminflammatorysyndromeinchildren AT aysunsoyuguzel relationshipbetweensysteminvolvementandvitamindlevelincasesdiagnosedwithmultisysteminflammatorysyndromeinchildren AT aysegulbukulmez relationshipbetweensysteminvolvementandvitamindlevelincasesdiagnosedwithmultisysteminflammatorysyndromeinchildren AT ayhanpektas relationshipbetweensysteminvolvementandvitamindlevelincasesdiagnosedwithmultisysteminflammatorysyndromeinchildren AT ibrahimeker relationshipbetweensysteminvolvementandvitamindlevelincasesdiagnosedwithmultisysteminflammatorysyndromeinchildren AT mehmetcelegen relationshipbetweensysteminvolvementandvitamindlevelincasesdiagnosedwithmultisysteminflammatorysyndromeinchildren AT hilalkoyuncu relationshipbetweensysteminvolvementandvitamindlevelincasesdiagnosedwithmultisysteminflammatorysyndromeinchildren |