Olmesartan-Induced Enteropathy: A Rare Case of Chronic Diarrhea

The case involves a 63-year-old hypertensive man, taking antihypertensive medication (olmesartan) for the previous two years, who sought medical attention due to voluminous diarrhea, with several episodes per day and weight loss of 10 kg. He was submitted to a series of diagnostic procedures without...

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Main Authors: Sofia Emerenciano Gurgel, Kleyton Santos de Medeiros, Sarah Jane Lima de Paiva, José Gurgel Filho
Format: Article
Language:English
Published: Wiley 2024-01-01
Series:Case Reports in Medicine
Online Access:http://dx.doi.org/10.1155/carm/2666671
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author Sofia Emerenciano Gurgel
Kleyton Santos de Medeiros
Sarah Jane Lima de Paiva
José Gurgel Filho
author_facet Sofia Emerenciano Gurgel
Kleyton Santos de Medeiros
Sarah Jane Lima de Paiva
José Gurgel Filho
author_sort Sofia Emerenciano Gurgel
collection DOAJ
description The case involves a 63-year-old hypertensive man, taking antihypertensive medication (olmesartan) for the previous two years, who sought medical attention due to voluminous diarrhea, with several episodes per day and weight loss of 10 kg. He was submitted to a series of diagnostic procedures without elucidation and empirical treatment with unsuccessful outcome. After hospitalization for clinical stabilization and for presenting with duodenal atrophy, obtained by duodenal biopsy associated with negative markers for celiac disease, the patient was diagnosed with suspected olmesartan-induced enteropathy, showing rapid improvement of diarrhea after the drug was withdrawn, with weight regain in 6 months and normalization of the duodenal histological picture after 10 months.
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institution Kabale University
issn 1687-9635
language English
publishDate 2024-01-01
publisher Wiley
record_format Article
series Case Reports in Medicine
spelling doaj-art-84a84c05b3e64ce5b4de7052f91e75792024-12-27T00:00:10ZengWileyCase Reports in Medicine1687-96352024-01-01202410.1155/carm/2666671Olmesartan-Induced Enteropathy: A Rare Case of Chronic DiarrheaSofia Emerenciano Gurgel0Kleyton Santos de Medeiros1Sarah Jane Lima de Paiva2José Gurgel Filho3Department of NeuroscienceInstituto de EnsinoDepartment of PathologyDepartment of GastroenterologyThe case involves a 63-year-old hypertensive man, taking antihypertensive medication (olmesartan) for the previous two years, who sought medical attention due to voluminous diarrhea, with several episodes per day and weight loss of 10 kg. He was submitted to a series of diagnostic procedures without elucidation and empirical treatment with unsuccessful outcome. After hospitalization for clinical stabilization and for presenting with duodenal atrophy, obtained by duodenal biopsy associated with negative markers for celiac disease, the patient was diagnosed with suspected olmesartan-induced enteropathy, showing rapid improvement of diarrhea after the drug was withdrawn, with weight regain in 6 months and normalization of the duodenal histological picture after 10 months.http://dx.doi.org/10.1155/carm/2666671
spellingShingle Sofia Emerenciano Gurgel
Kleyton Santos de Medeiros
Sarah Jane Lima de Paiva
José Gurgel Filho
Olmesartan-Induced Enteropathy: A Rare Case of Chronic Diarrhea
Case Reports in Medicine
title Olmesartan-Induced Enteropathy: A Rare Case of Chronic Diarrhea
title_full Olmesartan-Induced Enteropathy: A Rare Case of Chronic Diarrhea
title_fullStr Olmesartan-Induced Enteropathy: A Rare Case of Chronic Diarrhea
title_full_unstemmed Olmesartan-Induced Enteropathy: A Rare Case of Chronic Diarrhea
title_short Olmesartan-Induced Enteropathy: A Rare Case of Chronic Diarrhea
title_sort olmesartan induced enteropathy a rare case of chronic diarrhea
url http://dx.doi.org/10.1155/carm/2666671
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AT kleytonsantosdemedeiros olmesartaninducedenteropathyararecaseofchronicdiarrhea
AT sarahjanelimadepaiva olmesartaninducedenteropathyararecaseofchronicdiarrhea
AT josegurgelfilho olmesartaninducedenteropathyararecaseofchronicdiarrhea