Chemogenetic engagement of different GPCR signaling pathways segregates the orexigenic activity from the control of whole-body glucose metabolism by AGRP neurons

Chemogenetic engagement of different GPCR signaling pathways segregates the orexigenic activity from the control of whole-body glucose metabolism by AGRP neurons

Objective: The control of energy balance involves neural circuits in the central nervous system, including AGRP neurons in the arcuate nucleus of the hypothalamus (ARC). AGRP neurons are crucial for energy balance and their increased activity during fasting is critical to promote feeding behavior. T...

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Bibliographic Details
Main Authors: Valerie Espinal Abreu, Rachel Barnes, Vishnupriya Borra, Jennifer Schurdak, Diego Perez-Tilve
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Molecular Metabolism
Subjects:
Chemogenetics
Agrp neurons
Sympathetic nervous system
Glucose tolerance
Insulin resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877824002102
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