Mechanism of HIF-1α promoting proliferation, invasion and metastasis of nasopharyngeal carcinoma by regulating MMP-2 in hypoxic microenvironment

Mechanism of HIF-1α promoting proliferation, invasion and metastasis of nasopharyngeal carcinoma by regulating MMP-2 in hypoxic microenvironment

Objective: To explore the mechanism of HIF-1α promoting the proliferation, invasion and metastasis of nasopharyngeal carcinoma cells by regulating the expression of MMP-2. Methods: 30 nasopharyngeal carcinoma tissues and 30 normal nasopharyngeal epithelial tissues were collected, and the expression...

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Bibliographic Details
Main Authors: Ying Lan, Shijie Zhao, Tao Hou, Yi Ren, Jun Tang, Shihua Yin, Yang Wu
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Heliyon
Subjects:
Hypoxia
HIF-1α
MMP-2
Nasopharyngeal carcinoma
Proliferation
Invasion and metastasis
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024167916
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http://www.sciencedirect.com/science/article/pii/S2405844024167916

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