Association between population viral load surrogate indicator and HIV transmission potential: a prospective cohort study in Xinjiang, China
Abstract Background New indicators of potential human immunodeficiency virus (HIV) transmission are being actively explored. We aim to categorical testing of the viral load (VL) of persons living with HIV (PLWH) in order to explore new indicators to measure the intensity of the epidemic and the effe...
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2025-01-01
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| Online Access: | https://doi.org/10.1186/s12889-025-21278-6 |
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| author | Qian He Yongkang Ni Yuefei Li Xiaoyuan Hu Xiaomin Hu Zhen Ni Changyu Zeng Aizimaiti Aikebaier Bixin Xu Mingjian Ni |
| author_facet | Qian He Yongkang Ni Yuefei Li Xiaoyuan Hu Xiaomin Hu Zhen Ni Changyu Zeng Aizimaiti Aikebaier Bixin Xu Mingjian Ni |
| author_sort | Qian He |
| collection | DOAJ |
| description | Abstract Background New indicators of potential human immunodeficiency virus (HIV) transmission are being actively explored. We aim to categorical testing of the viral load (VL) of persons living with HIV (PLWH) in order to explore new indicators to measure the intensity of the epidemic and the effectiveness of the response in the community. Methods A dynamic cohort study was conducted in Yining to monitor the VL of all persons living with HIV from 2017 to 2019. Different population VL (PVL) surrogate indicators were measured and the strength of the associations of different PVL surrogates with HIV incidence, antiretroviral therapy (ART) coverage, virus unsuppression, and viremia prevalence was assessed. PVL surrogate indicators were used to describe the current status of HIV transmission in different populations and communities. Results All PVL indicators decreased from 2017 to 2019 (P < 0.05). Arithmetic mean community viral load (CVL) (r = 1.000, P = 0.006) and geometric mean CVL (r = 1.000, P = 0.001) were positively associated with HIV incidence, ART coverage and viral unsuppression (P < 0.05). CVL was higher in the male, ≤ 25 years of age, primary school or below, other household registration, other medical insurance types, other source of sample, nonmarital and noncommercial heterosexual contact, and nonmarital and commercial heterosexual contact subgroups. Community-based cross-sectional analyses showed that CVL in community 10 was positively correlated with viral unsuppression rate and viremia prevalence but negatively correlated with ART coverage rate, suggesting that the community was a hotspot for HIV epidemics. Conclusions CVL can be used as an indicator for assessing HIV transmission and identifying high-risk populations and hotspot communities. |
| format | Article |
| id | doaj-art-8463881f35de4c3aaccef8d341f451ca |
| institution | Kabale University |
| issn | 1471-2458 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | BMC Public Health |
| spelling | doaj-art-8463881f35de4c3aaccef8d341f451ca2025-01-12T12:42:31ZengBMCBMC Public Health1471-24582025-01-0125111310.1186/s12889-025-21278-6Association between population viral load surrogate indicator and HIV transmission potential: a prospective cohort study in Xinjiang, ChinaQian He0Yongkang Ni1Yuefei Li2Xiaoyuan Hu3Xiaomin Hu4Zhen Ni5Changyu Zeng6Aizimaiti Aikebaier7Bixin Xu8Mingjian Ni9School of public health, Xinjiang Medical UniversitySchool of public health, Xinjiang Medical UniversitySchool of public health, Xinjiang Medical UniversityXinjiang Uighur Autonomous Region Center for Disease Control and PreventionXinjiang Uighur Autonomous Region Center for Disease Control and PreventionXinjiang Uighur Autonomous Region Center for Disease Control and PreventionXinjiang Uighur Autonomous Region Center for Disease Control and PreventionXinjiang medical University Affiliated Hospital of Traditional Chinese MedicineYining Center for Disease Control and PreventionXinjiang Uighur Autonomous Region Center for Disease Control and PreventionAbstract Background New indicators of potential human immunodeficiency virus (HIV) transmission are being actively explored. We aim to categorical testing of the viral load (VL) of persons living with HIV (PLWH) in order to explore new indicators to measure the intensity of the epidemic and the effectiveness of the response in the community. Methods A dynamic cohort study was conducted in Yining to monitor the VL of all persons living with HIV from 2017 to 2019. Different population VL (PVL) surrogate indicators were measured and the strength of the associations of different PVL surrogates with HIV incidence, antiretroviral therapy (ART) coverage, virus unsuppression, and viremia prevalence was assessed. PVL surrogate indicators were used to describe the current status of HIV transmission in different populations and communities. Results All PVL indicators decreased from 2017 to 2019 (P < 0.05). Arithmetic mean community viral load (CVL) (r = 1.000, P = 0.006) and geometric mean CVL (r = 1.000, P = 0.001) were positively associated with HIV incidence, ART coverage and viral unsuppression (P < 0.05). CVL was higher in the male, ≤ 25 years of age, primary school or below, other household registration, other medical insurance types, other source of sample, nonmarital and noncommercial heterosexual contact, and nonmarital and commercial heterosexual contact subgroups. Community-based cross-sectional analyses showed that CVL in community 10 was positively correlated with viral unsuppression rate and viremia prevalence but negatively correlated with ART coverage rate, suggesting that the community was a hotspot for HIV epidemics. Conclusions CVL can be used as an indicator for assessing HIV transmission and identifying high-risk populations and hotspot communities.https://doi.org/10.1186/s12889-025-21278-6Persons living with HIV (PLWH)Community viral load (CVL)HIV incidenceCohort studyHIV transmission potential |
| spellingShingle | Qian He Yongkang Ni Yuefei Li Xiaoyuan Hu Xiaomin Hu Zhen Ni Changyu Zeng Aizimaiti Aikebaier Bixin Xu Mingjian Ni Association between population viral load surrogate indicator and HIV transmission potential: a prospective cohort study in Xinjiang, China BMC Public Health Persons living with HIV (PLWH) Community viral load (CVL) HIV incidence Cohort study HIV transmission potential |
| title | Association between population viral load surrogate indicator and HIV transmission potential: a prospective cohort study in Xinjiang, China |
| title_full | Association between population viral load surrogate indicator and HIV transmission potential: a prospective cohort study in Xinjiang, China |
| title_fullStr | Association between population viral load surrogate indicator and HIV transmission potential: a prospective cohort study in Xinjiang, China |
| title_full_unstemmed | Association between population viral load surrogate indicator and HIV transmission potential: a prospective cohort study in Xinjiang, China |
| title_short | Association between population viral load surrogate indicator and HIV transmission potential: a prospective cohort study in Xinjiang, China |
| title_sort | association between population viral load surrogate indicator and hiv transmission potential a prospective cohort study in xinjiang china |
| topic | Persons living with HIV (PLWH) Community viral load (CVL) HIV incidence Cohort study HIV transmission potential |
| url | https://doi.org/10.1186/s12889-025-21278-6 |
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