The relationship between muscle sympathetic nerve activity and serum fatty acid binding protein 4 at rest and during isometric handgrip exercise
Abstract Fatty acid binding protein 4 (FABP4) is highly expressed in adipocytes. Lipolysis, caused by an elevated adrenergic input, has been suggested to contribute to elevated serum FABP4 levels in patients with cardiovascular diseases. However, the relationship between the serum FABP4 and efferent...
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Wiley
2024-12-01
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| Online Access: | https://doi.org/10.14814/phy2.70122 |
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| author | Tadayuki Hirai Takuto Hamaoka Hisayoshi Murai Hiroyuki Sugimoto Yusuke Mukai Ayano Nomura Takashi Kusayama Tatsunori Ikeda Shinichiro Takashima Takeshi Kato Kenji Sakata Soichiro Usui Shigeo Takata Masayuki Takamura |
| author_facet | Tadayuki Hirai Takuto Hamaoka Hisayoshi Murai Hiroyuki Sugimoto Yusuke Mukai Ayano Nomura Takashi Kusayama Tatsunori Ikeda Shinichiro Takashima Takeshi Kato Kenji Sakata Soichiro Usui Shigeo Takata Masayuki Takamura |
| author_sort | Tadayuki Hirai |
| collection | DOAJ |
| description | Abstract Fatty acid binding protein 4 (FABP4) is highly expressed in adipocytes. Lipolysis, caused by an elevated adrenergic input, has been suggested to contribute to elevated serum FABP4 levels in patients with cardiovascular diseases. However, the relationship between the serum FABP4 and efferent sympathetic nerve activity remains poorly understood. Twenty‐one healthy subjects (average age, 29.1 years; 15 men) performed an isometric handgrip (HG) exercise at 30% of the maximal voluntary contraction until they were fatigued. The beat‐by‐beat heart rate (HR), blood pressure (BP), and muscle sympathetic nerve activity (MSNA) were recorded. Blood samples were collected at rest and at the time of peak fatigue. The MSNA, HR, and systolic BP were significantly increased by the HG exercise (all, p < 0.05). MSNA was obtained from 14 patients. The change in the FABP4 on HG exercise was significantly correlated with the change in MSNA (bursts/100 heartbeats) (R = 0.808, p < 0.001) but not with changes in other parameters, which might, in part, reflect an association of efferent sympathetic drive with FABP4. Meanwhile, resting FABP4 levels were not associated with any parameters including MSNA, in healthy individuals. Future studies on patients with elevated sympathetic activity are warranted to examine the relationship further. |
| format | Article |
| id | doaj-art-844ab0271ace49a197faef3c03a97a38 |
| institution | Kabale University |
| issn | 2051-817X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj-art-844ab0271ace49a197faef3c03a97a382024-12-31T08:52:31ZengWileyPhysiological Reports2051-817X2024-12-011224n/an/a10.14814/phy2.70122The relationship between muscle sympathetic nerve activity and serum fatty acid binding protein 4 at rest and during isometric handgrip exerciseTadayuki Hirai0Takuto Hamaoka1Hisayoshi Murai2Hiroyuki Sugimoto3Yusuke Mukai4Ayano Nomura5Takashi Kusayama6Tatsunori Ikeda7Shinichiro Takashima8Takeshi Kato9Kenji Sakata10Soichiro Usui11Shigeo Takata12Masayuki Takamura13Department of Cardiovascular Medicine Kanazawa University Graduate School of Medical Sciences Kanazawa JapanDepartment of Cardiovascular Medicine Kanazawa University Graduate School of Medical Sciences Kanazawa JapanDepartment of Cardiovascular Medicine Kanazawa University Graduate School of Medical Sciences Kanazawa JapanDepartment of Cardiovascular Medicine Kanazawa University Graduate School of Medical Sciences Kanazawa JapanDepartment of Cardiovascular Medicine Kanazawa University Graduate School of Medical Sciences Kanazawa JapanDepartment of Cardiovascular Medicine Kanazawa University Graduate School of Medical Sciences Kanazawa JapanDepartment of Cardiovascular Medicine Kanazawa University Graduate School of Medical Sciences Kanazawa JapanDepartment of Cardiovascular Medicine Kanazawa University Graduate School of Medical Sciences Kanazawa JapanDepartment of Cardiovascular Medicine Kanazawa University Graduate School of Medical Sciences Kanazawa JapanDepartment of Cardiovascular Medicine Kanazawa University Graduate School of Medical Sciences Kanazawa JapanDepartment of Cardiovascular Medicine Kanazawa University Graduate School of Medical Sciences Kanazawa JapanDepartment of Cardiovascular Medicine Kanazawa University Graduate School of Medical Sciences Kanazawa JapanKanazawa Municipal Hospital Kanazawa JapanDepartment of Cardiovascular Medicine Kanazawa University Graduate School of Medical Sciences Kanazawa JapanAbstract Fatty acid binding protein 4 (FABP4) is highly expressed in adipocytes. Lipolysis, caused by an elevated adrenergic input, has been suggested to contribute to elevated serum FABP4 levels in patients with cardiovascular diseases. However, the relationship between the serum FABP4 and efferent sympathetic nerve activity remains poorly understood. Twenty‐one healthy subjects (average age, 29.1 years; 15 men) performed an isometric handgrip (HG) exercise at 30% of the maximal voluntary contraction until they were fatigued. The beat‐by‐beat heart rate (HR), blood pressure (BP), and muscle sympathetic nerve activity (MSNA) were recorded. Blood samples were collected at rest and at the time of peak fatigue. The MSNA, HR, and systolic BP were significantly increased by the HG exercise (all, p < 0.05). MSNA was obtained from 14 patients. The change in the FABP4 on HG exercise was significantly correlated with the change in MSNA (bursts/100 heartbeats) (R = 0.808, p < 0.001) but not with changes in other parameters, which might, in part, reflect an association of efferent sympathetic drive with FABP4. Meanwhile, resting FABP4 levels were not associated with any parameters including MSNA, in healthy individuals. Future studies on patients with elevated sympathetic activity are warranted to examine the relationship further.https://doi.org/10.14814/phy2.70122catecholaminesFABP4handgrip exerciselipolysisvsympathetic nervous system |
| spellingShingle | Tadayuki Hirai Takuto Hamaoka Hisayoshi Murai Hiroyuki Sugimoto Yusuke Mukai Ayano Nomura Takashi Kusayama Tatsunori Ikeda Shinichiro Takashima Takeshi Kato Kenji Sakata Soichiro Usui Shigeo Takata Masayuki Takamura The relationship between muscle sympathetic nerve activity and serum fatty acid binding protein 4 at rest and during isometric handgrip exercise Physiological Reports catecholamines FABP4 handgrip exercise lipolysisv sympathetic nervous system |
| title | The relationship between muscle sympathetic nerve activity and serum fatty acid binding protein 4 at rest and during isometric handgrip exercise |
| title_full | The relationship between muscle sympathetic nerve activity and serum fatty acid binding protein 4 at rest and during isometric handgrip exercise |
| title_fullStr | The relationship between muscle sympathetic nerve activity and serum fatty acid binding protein 4 at rest and during isometric handgrip exercise |
| title_full_unstemmed | The relationship between muscle sympathetic nerve activity and serum fatty acid binding protein 4 at rest and during isometric handgrip exercise |
| title_short | The relationship between muscle sympathetic nerve activity and serum fatty acid binding protein 4 at rest and during isometric handgrip exercise |
| title_sort | relationship between muscle sympathetic nerve activity and serum fatty acid binding protein 4 at rest and during isometric handgrip exercise |
| topic | catecholamines FABP4 handgrip exercise lipolysisv sympathetic nervous system |
| url | https://doi.org/10.14814/phy2.70122 |
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