Investigating the association of microRNA polymorphisms and lifestyle factors with the susceptibility to common gastrointestinal cancers in an Indian population- A case control study
The cancers of the gastrointestinal (GI) tract have become a common diagnosis worldwide contributing to a large number of mortalities. Though potentially curable they are mostly fatal due to late diagnosis and lack of accurate diagnostic markers. microRNA, micromanagers of gene expression have been...
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Elsevier
2025-01-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024175500 |
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| author | Charles Emmanuel Jebaraj Walter Zioni Sangeetha Shankaran Sai Sushmitha Kontham Kotteeswaran Ramachandran Nandini Prakash Thanka Johnson Sri Nisha JR |
| author_facet | Charles Emmanuel Jebaraj Walter Zioni Sangeetha Shankaran Sai Sushmitha Kontham Kotteeswaran Ramachandran Nandini Prakash Thanka Johnson Sri Nisha JR |
| author_sort | Charles Emmanuel Jebaraj Walter |
| collection | DOAJ |
| description | The cancers of the gastrointestinal (GI) tract have become a common diagnosis worldwide contributing to a large number of mortalities. Though potentially curable they are mostly fatal due to late diagnosis and lack of accurate diagnostic markers. microRNA, micromanagers of gene expression have been associated to have distinct roles as oncogenes or tumour suppressors in several cancers including GI cancers. These miRNAs are known to harbour single nucleotide polymorphisms (SNPs) that lead to loss or gain of its functions and have been found to be associated with altering susceptibility of several cancers. The current study aimed to investigate the role of miRSNPs in common gastrointestinal cancers. A case control study was designed which included 210 GI cancer cases and 230 cancer free controls. The miRSNPs were successfully genotyped using MassARRAY technique. Association analysis revealed that miR-196a; rs11614913, pre-mir-423; rs6505162, pre-mir-605; rs2043556, pre-mir-149; rs2292832 and pri-mir-30c; rs928508 polymorphisms significantly altered the risk of common GI cancers. Multifactor dimensionality reduction analysis demonstrated that miRSNPs alter GI cancer risk by interacting with exposures like diabetes mellitus, alcohol consumption, diet and socioeconomic status in the study subjects. In conclusion it was found that presence of miRNA polymorphism and certain lifestyle factors alters susceptibility to GI cancers significantly. |
| format | Article |
| id | doaj-art-8426704c64ff4c23b6476ec86fbc449f |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-8426704c64ff4c23b6476ec86fbc449f2025-01-17T04:51:31ZengElsevierHeliyon2405-84402025-01-01111e41519Investigating the association of microRNA polymorphisms and lifestyle factors with the susceptibility to common gastrointestinal cancers in an Indian population- A case control studyCharles Emmanuel Jebaraj Walter0Zioni Sangeetha Shankaran1Sai Sushmitha Kontham2Kotteeswaran Ramachandran3Nandini Prakash4Thanka Johnson5Sri Nisha JR6Department of Biotechnology, Sri Ramachandra Institute of Higher Education & Research (formerly Sri Ramachandra Medical College & Research Institute), Chennai, India; Corresponding author. Biotechnology, Sri Ramachandra Institute of Higher Education & Research (formerly Sri Ramachandra Medical College & Research Institute), Chennai, IndiaDepartment of Biotechnology, Sri Ramachandra Institute of Higher Education & Research (formerly Sri Ramachandra Medical College & Research Institute), Chennai, India; Biomedical Sciences, Faculty of Allied Health Sciences, Sree Balaji Medical College & Hospital, Chennai, IndiaDepartment of Biotechnology, Sri Ramachandra Institute of Higher Education & Research (formerly Sri Ramachandra Medical College & Research Institute), Chennai, IndiaMBBS Graduate, Kanyakumari Medical College, Kanyakumari District, Tamilnadu, IndiaDepartment of Biotechnology, Sri Ramachandra Institute of Higher Education & Research (formerly Sri Ramachandra Medical College & Research Institute), Chennai, IndiaDepartment of Pathology, Sree Balaji Medical College & Hospital, Chennai, IndiaDepartment of Prosthodontia, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education & Research, Chennai, India; Corresponding author. Dental College & Hospital, Bharath Institute of Higher Education & Research, Chennai, India.The cancers of the gastrointestinal (GI) tract have become a common diagnosis worldwide contributing to a large number of mortalities. Though potentially curable they are mostly fatal due to late diagnosis and lack of accurate diagnostic markers. microRNA, micromanagers of gene expression have been associated to have distinct roles as oncogenes or tumour suppressors in several cancers including GI cancers. These miRNAs are known to harbour single nucleotide polymorphisms (SNPs) that lead to loss or gain of its functions and have been found to be associated with altering susceptibility of several cancers. The current study aimed to investigate the role of miRSNPs in common gastrointestinal cancers. A case control study was designed which included 210 GI cancer cases and 230 cancer free controls. The miRSNPs were successfully genotyped using MassARRAY technique. Association analysis revealed that miR-196a; rs11614913, pre-mir-423; rs6505162, pre-mir-605; rs2043556, pre-mir-149; rs2292832 and pri-mir-30c; rs928508 polymorphisms significantly altered the risk of common GI cancers. Multifactor dimensionality reduction analysis demonstrated that miRSNPs alter GI cancer risk by interacting with exposures like diabetes mellitus, alcohol consumption, diet and socioeconomic status in the study subjects. In conclusion it was found that presence of miRNA polymorphism and certain lifestyle factors alters susceptibility to GI cancers significantly.http://www.sciencedirect.com/science/article/pii/S2405844024175500Gastrointestinal cancersMicroRNASingle nucleotide polymorphismsMultifactor dimensionality reductionLifestyle factorsMassARRAY |
| spellingShingle | Charles Emmanuel Jebaraj Walter Zioni Sangeetha Shankaran Sai Sushmitha Kontham Kotteeswaran Ramachandran Nandini Prakash Thanka Johnson Sri Nisha JR Investigating the association of microRNA polymorphisms and lifestyle factors with the susceptibility to common gastrointestinal cancers in an Indian population- A case control study Heliyon Gastrointestinal cancers MicroRNA Single nucleotide polymorphisms Multifactor dimensionality reduction Lifestyle factors MassARRAY |
| title | Investigating the association of microRNA polymorphisms and lifestyle factors with the susceptibility to common gastrointestinal cancers in an Indian population- A case control study |
| title_full | Investigating the association of microRNA polymorphisms and lifestyle factors with the susceptibility to common gastrointestinal cancers in an Indian population- A case control study |
| title_fullStr | Investigating the association of microRNA polymorphisms and lifestyle factors with the susceptibility to common gastrointestinal cancers in an Indian population- A case control study |
| title_full_unstemmed | Investigating the association of microRNA polymorphisms and lifestyle factors with the susceptibility to common gastrointestinal cancers in an Indian population- A case control study |
| title_short | Investigating the association of microRNA polymorphisms and lifestyle factors with the susceptibility to common gastrointestinal cancers in an Indian population- A case control study |
| title_sort | investigating the association of microrna polymorphisms and lifestyle factors with the susceptibility to common gastrointestinal cancers in an indian population a case control study |
| topic | Gastrointestinal cancers MicroRNA Single nucleotide polymorphisms Multifactor dimensionality reduction Lifestyle factors MassARRAY |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024175500 |
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