Kinetic analysis of ternary and binary binding modes of the bispecific antibody emicizumab

Kinetic analysis of ternary and binary binding modes of the bispecific antibody emicizumab

The binding properties of bispecific antibodies (bsAb) are crucial for their function, especially when two antigens are targeted on the same cell surface. Dynamic interactions between each of the antibody’s arms and its cognate target cause the formation and decay of a biologically functional ternar...

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Bibliographic Details
Main Authors: Stefanie Mak, Agnes Marszal, Nena Matscheko, Ulrich Rant
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:mAbs
Subjects:
Bispecific
antibody
binding
kinetics
avidity
switchSENSE
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2022.2149053
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