Manipulated Slow Release of Florfenicol Hydrogels for Effective Treatment of Anti-Intestinal Bacterial Infections
Wanhe Luo,1,2 Mengdi Zhang,1 Yongtao Jiang,1 Guocai Ma,3 Jinhuan Liu,1,4 Ali Sobhy Dawood,5 Shuyu Xie,6 Samah Attia Algharib7 1College of Animal Science and Technology, Tarim University, Alar, Xinjiang, 843300, People’s Republic of China; 2Key Laboratory of Livestock and Forage Resources Utilization...
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Dove Medical Press
2025-01-01
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| Series: | International Journal of Nanomedicine |
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| author | Luo W Zhang M Jiang Y Ma G Liu J Dawood AS Xie S Algharib SA |
| author_facet | Luo W Zhang M Jiang Y Ma G Liu J Dawood AS Xie S Algharib SA |
| author_sort | Luo W |
| collection | DOAJ |
| description | Wanhe Luo,1,2 Mengdi Zhang,1 Yongtao Jiang,1 Guocai Ma,3 Jinhuan Liu,1,4 Ali Sobhy Dawood,5 Shuyu Xie,6 Samah Attia Algharib7 1College of Animal Science and Technology, Tarim University, Alar, Xinjiang, 843300, People’s Republic of China; 2Key Laboratory of Livestock and Forage Resources Utilization Around Tarim, Ministry of Agriculture and Rural Areas, Tarim University, Alar, Xinjiang, 843300, People’s Republic of China; 3Instrumental Analysis Center, Tarim University, Alar, Xinjiang, 843300, People’s Republic of China; 4Lab for Sustainable Antimicrobials, Department of Pharmacy, Sichuan Agricultural University, Chengdu, Sichuan, 610000, People’s Republic of China; 5Medicine and Infectious Diseases Department, Faculty of Veterinary Medicine, University of Sadat City, Sadat city, 32897, Egypt; 6National Reference Laboratory of Veterinary Drug Residues (HZAU) and MARA Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, 430070, People’s Republic of China; 7Department of Clinical Pathology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, 13736, EgyptCorrespondence: Wanhe Luo; Samah Attia Algharib, Email luowanhe0728@163.com; samah.alghareeb@fvtm.bu.edu.egObjective: The difficulty of establishing slow release at intestinal infection sites, weak antibacterial effects, as well as the limited broad use of florfenicol oral formulations are the main targets of the current study. Novel hydrogels derived from sodium alginate were developed using a complexation form for florfenicol delivery to achieve slow release at the site of intestinal infection and enhance its antibacterial activity against Escherichia coli.Methods: The optimal formulation, physicochemical properties, stability, pH-responsive performance, antibacterial activity, and in vitro biosafety of the florfenicol hydrogels have been studied systematically.Results: The created hydrogels had a consistent spherical morphology, with an average diameter of 531.9± 12.6 nm. Energy dispersive spectroscopy and Fourier transform infrared indicated that florfenicol hydrogels have been successfully prepared through complexation force. Furthermore, it is shown that florfenicol hydrogels hold outstanding stability, excellent sustained release, and faster swelling and release at intestinal pH due to pH-responsiveness. The florfenicol hydrogels had no obvious structural destruction in simulated gastric juice (pH=1.2) for 12 hrs and were highly stable. However, the hydrogels began to be destroyed after 5 minutes in simulated intestinal fluid (SIF), and this decomposition was continuous. With the decomposition of the structure of florfenicol hydrogels, the encapsulated florfenicol was also slowly released, and thus, it achieves the slow-release effect. Additionally, the florfenicol hydrogels showed a low hemolytic ratio and greater antibacterial activity compared with florfenicol.Conclusion: The blended formulation creates a promising oral matrix intended for the slow-release of florfenicol along the gastrointestinal tract.Keywords: florfenicol, intestinal bacterial infections, hydrogels, sodium alginate, slow-release |
| format | Article |
| id | doaj-art-841ff0a4d0104d06bf85637f99f1b47f |
| institution | Kabale University |
| issn | 1178-2013 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj-art-841ff0a4d0104d06bf85637f99f1b47f2025-01-14T16:51:43ZengDove Medical PressInternational Journal of Nanomedicine1178-20132025-01-01Volume 2054155599215Manipulated Slow Release of Florfenicol Hydrogels for Effective Treatment of Anti-Intestinal Bacterial InfectionsLuo WZhang MJiang YMa GLiu JDawood ASXie SAlgharib SAWanhe Luo,1,2 Mengdi Zhang,1 Yongtao Jiang,1 Guocai Ma,3 Jinhuan Liu,1,4 Ali Sobhy Dawood,5 Shuyu Xie,6 Samah Attia Algharib7 1College of Animal Science and Technology, Tarim University, Alar, Xinjiang, 843300, People’s Republic of China; 2Key Laboratory of Livestock and Forage Resources Utilization Around Tarim, Ministry of Agriculture and Rural Areas, Tarim University, Alar, Xinjiang, 843300, People’s Republic of China; 3Instrumental Analysis Center, Tarim University, Alar, Xinjiang, 843300, People’s Republic of China; 4Lab for Sustainable Antimicrobials, Department of Pharmacy, Sichuan Agricultural University, Chengdu, Sichuan, 610000, People’s Republic of China; 5Medicine and Infectious Diseases Department, Faculty of Veterinary Medicine, University of Sadat City, Sadat city, 32897, Egypt; 6National Reference Laboratory of Veterinary Drug Residues (HZAU) and MARA Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, 430070, People’s Republic of China; 7Department of Clinical Pathology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, 13736, EgyptCorrespondence: Wanhe Luo; Samah Attia Algharib, Email luowanhe0728@163.com; samah.alghareeb@fvtm.bu.edu.egObjective: The difficulty of establishing slow release at intestinal infection sites, weak antibacterial effects, as well as the limited broad use of florfenicol oral formulations are the main targets of the current study. Novel hydrogels derived from sodium alginate were developed using a complexation form for florfenicol delivery to achieve slow release at the site of intestinal infection and enhance its antibacterial activity against Escherichia coli.Methods: The optimal formulation, physicochemical properties, stability, pH-responsive performance, antibacterial activity, and in vitro biosafety of the florfenicol hydrogels have been studied systematically.Results: The created hydrogels had a consistent spherical morphology, with an average diameter of 531.9± 12.6 nm. Energy dispersive spectroscopy and Fourier transform infrared indicated that florfenicol hydrogels have been successfully prepared through complexation force. Furthermore, it is shown that florfenicol hydrogels hold outstanding stability, excellent sustained release, and faster swelling and release at intestinal pH due to pH-responsiveness. The florfenicol hydrogels had no obvious structural destruction in simulated gastric juice (pH=1.2) for 12 hrs and were highly stable. However, the hydrogels began to be destroyed after 5 minutes in simulated intestinal fluid (SIF), and this decomposition was continuous. With the decomposition of the structure of florfenicol hydrogels, the encapsulated florfenicol was also slowly released, and thus, it achieves the slow-release effect. Additionally, the florfenicol hydrogels showed a low hemolytic ratio and greater antibacterial activity compared with florfenicol.Conclusion: The blended formulation creates a promising oral matrix intended for the slow-release of florfenicol along the gastrointestinal tract.Keywords: florfenicol, intestinal bacterial infections, hydrogels, sodium alginate, slow-releasehttps://www.dovepress.com/manipulated-slow-release-of-florfenicol-hydrogels-for-effective-treatm-peer-reviewed-fulltext-article-IJNflorfenicolintestinal bacterial infectionshydrogelssodium alginateslow-release |
| spellingShingle | Luo W Zhang M Jiang Y Ma G Liu J Dawood AS Xie S Algharib SA Manipulated Slow Release of Florfenicol Hydrogels for Effective Treatment of Anti-Intestinal Bacterial Infections International Journal of Nanomedicine florfenicol intestinal bacterial infections hydrogels sodium alginate slow-release |
| title | Manipulated Slow Release of Florfenicol Hydrogels for Effective Treatment of Anti-Intestinal Bacterial Infections |
| title_full | Manipulated Slow Release of Florfenicol Hydrogels for Effective Treatment of Anti-Intestinal Bacterial Infections |
| title_fullStr | Manipulated Slow Release of Florfenicol Hydrogels for Effective Treatment of Anti-Intestinal Bacterial Infections |
| title_full_unstemmed | Manipulated Slow Release of Florfenicol Hydrogels for Effective Treatment of Anti-Intestinal Bacterial Infections |
| title_short | Manipulated Slow Release of Florfenicol Hydrogels for Effective Treatment of Anti-Intestinal Bacterial Infections |
| title_sort | manipulated slow release of florfenicol hydrogels for effective treatment of anti intestinal bacterial infections |
| topic | florfenicol intestinal bacterial infections hydrogels sodium alginate slow-release |
| url | https://www.dovepress.com/manipulated-slow-release-of-florfenicol-hydrogels-for-effective-treatm-peer-reviewed-fulltext-article-IJN |
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