Population pharmacokinetic analysis of quizartinib in patients with newly diagnosed FLT3‐internal‐tandem‐duplication‐positive acute myeloid leukemia

Population pharmacokinetic analysis of quizartinib in patients with newly diagnosed FLT3‐internal‐tandem‐duplication‐positive acute myeloid leukemia

Abstract The population pharmacokinetics (PK) of quizartinib and its pharmacologically active metabolite AC886 have been previously described in healthy volunteers (HV) and relapsed/refractory (R/R) FLT3‐internal‐tandem‐duplication‐positive (FLT3‐IDT‐positive) acute myeloid leukemia (AML) patients r...

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Main Authors: Pavan Vaddady, Anaïs Glatard, Giovanni Smania, Shintaro Nakayama, Hiroyuki Inoue, Abhinav Kurumaddali, Malaz Abutarif, Ming Zheng
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Clinical and Translational Science
Online Access:https://doi.org/10.1111/cts.70074
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