SELENOF gene as a quintessential target in oral squamous cell carcinoma
Goal of the Perspective: Antioxidant mechanism are irreversibly damaged and cause cellular and genetic changes in oral cancer. Selenium is an essential component of selenoproteins that help to make DNA and protect against cell damage. Discussion: Mutation or altered SELENOF gene expression eventuall...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Oral Oncology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772906024000529 |
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| author | Ramya Ramadoss Monal Yuwanati Abigail Viola E Pradeepkumar Yadalam Pratibha Ramani Sindhu Ramesh |
| author_facet | Ramya Ramadoss Monal Yuwanati Abigail Viola E Pradeepkumar Yadalam Pratibha Ramani Sindhu Ramesh |
| author_sort | Ramya Ramadoss |
| collection | DOAJ |
| description | Goal of the Perspective: Antioxidant mechanism are irreversibly damaged and cause cellular and genetic changes in oral cancer. Selenium is an essential component of selenoproteins that help to make DNA and protect against cell damage. Discussion: Mutation or altered SELENOF gene expression eventually leads to the oxidative damage to DNA due to alteration in anti-oxidative mechanism of selenoproteins and potentially increase risk of cancer development. Selenium substantially suppressed cell proliferation of cancerous cells in vitro and they could effectively produce oxidative stress and trigger apoptosis in oral cancer cells, hence inhibiting the oral cancer to some extent. Conclusion: Considering the beneficial anti-oxidant activities, it prudent to explore the possibility of targeting the SELENOF gene thereby enhancing the anti-tumor activity through Redox mechanism in OSCC. Interactome analysis revealed significant Hub genes and druggable sites of SELENOF in management of Oral squamous cell carcinoma. |
| format | Article |
| id | doaj-art-83e5566a61e2432293edc5e67bb7be96 |
| institution | Kabale University |
| issn | 2772-9060 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral Oncology Reports |
| spelling | doaj-art-83e5566a61e2432293edc5e67bb7be962025-01-09T06:15:20ZengElsevierOral Oncology Reports2772-90602024-03-019100206SELENOF gene as a quintessential target in oral squamous cell carcinomaRamya Ramadoss0Monal Yuwanati1Abigail Viola E2Pradeepkumar Yadalam3Pratibha Ramani4Sindhu Ramesh5Department of Oral Biology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 600077, India; Corresponding author.Department of Oral Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 600077, IndiaDepartment of Oral Pathology, SRM Dental College, Ramapuram, Chennai, 600089, IndiaDepartment of Periodontia, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 600077, IndiaDepartment of Oral Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 600077, IndiaDepartment of Conservative Dentistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 600077, IndiaGoal of the Perspective: Antioxidant mechanism are irreversibly damaged and cause cellular and genetic changes in oral cancer. Selenium is an essential component of selenoproteins that help to make DNA and protect against cell damage. Discussion: Mutation or altered SELENOF gene expression eventually leads to the oxidative damage to DNA due to alteration in anti-oxidative mechanism of selenoproteins and potentially increase risk of cancer development. Selenium substantially suppressed cell proliferation of cancerous cells in vitro and they could effectively produce oxidative stress and trigger apoptosis in oral cancer cells, hence inhibiting the oral cancer to some extent. Conclusion: Considering the beneficial anti-oxidant activities, it prudent to explore the possibility of targeting the SELENOF gene thereby enhancing the anti-tumor activity through Redox mechanism in OSCC. Interactome analysis revealed significant Hub genes and druggable sites of SELENOF in management of Oral squamous cell carcinoma.http://www.sciencedirect.com/science/article/pii/S2772906024000529SELENOFOral squamous cell carcinomaTargeted therapy |
| spellingShingle | Ramya Ramadoss Monal Yuwanati Abigail Viola E Pradeepkumar Yadalam Pratibha Ramani Sindhu Ramesh SELENOF gene as a quintessential target in oral squamous cell carcinoma Oral Oncology Reports SELENOF Oral squamous cell carcinoma Targeted therapy |
| title | SELENOF gene as a quintessential target in oral squamous cell carcinoma |
| title_full | SELENOF gene as a quintessential target in oral squamous cell carcinoma |
| title_fullStr | SELENOF gene as a quintessential target in oral squamous cell carcinoma |
| title_full_unstemmed | SELENOF gene as a quintessential target in oral squamous cell carcinoma |
| title_short | SELENOF gene as a quintessential target in oral squamous cell carcinoma |
| title_sort | selenof gene as a quintessential target in oral squamous cell carcinoma |
| topic | SELENOF Oral squamous cell carcinoma Targeted therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2772906024000529 |
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