IL-10 promotes Th17 cell differentiation by enhancing STAT1-dependent IL-6 production via IgE-stimulated mast cells

IL-10 promotes Th17 cell differentiation by enhancing STAT1-dependent IL-6 production via IgE-stimulated mast cells

Abstract Mast cells (MCs) are tissue-resident cells of hematopoietic origin that play an important role in host’s defense mechanism against nematodes. However, excessive activation of these cells contributes to the development of certain allergic diseases. Immunoglobin E (IgE) is one of the well-kno...

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Main Authors: Takafumi Numata, Masashi Ikutani, Ken Arae, Tatsukuni Ohno, Koki Okada, Takayuki Yoshimoto, Katsuko Sudo, Hajime Suto, Ko Okumura, Hirohisa Saito, Kazutoshi Harada, Susumu Nakae
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Mast cells
IL-10
STAT1
STAT3
Th17 cells
Online Access:https://doi.org/10.1038/s41598-024-77929-y
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