Influence of Interleukin IL-2 and IL-12 + IL-18 on Surface Expression of Immunoglobulin-Like Receptors KIR2DL1, KIR2DL2, and KIR3DL2 in Natural Killer Cells
Natural killer (NK) cells express killer cell inhibitory receptors (KIRs) that recognize polymorphic class I MHC molecules. In the present study, we analyze the modulatory effect of IL-2 alone or a combination of IL-12 with IL-18 on surface expression of killer cell immunoglobulin-like receptors KIR...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/46957 |
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| Summary: | Natural killer (NK) cells express killer cell
inhibitory receptors (KIRs) that recognize polymorphic class I MHC
molecules. In the present study, we analyze the modulatory effect
of IL-2 alone or a combination of IL-12 with IL-18 on surface
expression of killer cell immunoglobulin-like receptors KIR2DL1,
KIR2DL2, and KIR3DL2 in NK cells. Thus, it was found that IL-2
causes a significant increase in the proportion of cells with
given studied receptors. Stimulation by a mixture of IL-12 and
IL-18 caused significant increase in the fraction of cells with
the KIR2DL1 and KIR2DL2, however no significant change in the
percentage of cells with KIR3DL2 receptor on their surface was
observed. The results of the study show the presence of KIRs
on both resting and activated NK cells, this may suggest that KIRs
have also an important role in the regulatory processes after
activation of this subpopulation of cells. |
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| ISSN: | 0962-9351 1466-1861 |