Progress in Development of Functional Biological and Synthetic Blood Products to Augment Transfusable Blood Supply in Operational Medicine
A reliable, accessible, and high-quality blood supply is critical for the sustainment of any healthcare system. World events such as the COVID-19 pandemic have proven that maintaining the supply of blood presents a logistical challenge. The current blood supply is overseen by extensive donor program...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-03-01
|
| Series: | Bioengineering |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2306-5354/12/3/256 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849342521233113088 |
|---|---|
| author | Armando Estrada Orion Furmanski George J. Klarmann Nathan Scheidt Vincent B. Ho |
| author_facet | Armando Estrada Orion Furmanski George J. Klarmann Nathan Scheidt Vincent B. Ho |
| author_sort | Armando Estrada |
| collection | DOAJ |
| description | A reliable, accessible, and high-quality blood supply is critical for the sustainment of any healthcare system. World events such as the COVID-19 pandemic have proven that maintaining the supply of blood presents a logistical challenge. The current blood supply is overseen by extensive donor programs around the world. In the United States, as in other countries, the need for blood has increased, with a decline in blood donations and increasing exclusions for blood donor qualification. While there is a need to improve blood donation participation, there is also need for new alternatives to traditional donation to ensure readiness to treat hemorrhagic shock common in the setting of trauma, as often occurs during a natural disaster or conflict. These operational medicine scenarios require significant blood availability which may tax the current blood supply chain. Aside from a walking blood bank (WBB) model for blood collection in suboptimal conditions, researchers have proposed alternatives for blood that include the manufacturing of blood from stem cell sources. Other alternatives include synthetic liquids that can carry oxygen such as Perfluoro-Chemicals (PFCs) and hemoglobin-based oxygen-carrying systems (HBCOs). Here, we review some of these alternatives to the traditional donor blood model. Researchers now have the technology that makes it feasible to develop blood alternatives that one day may supplement and help alleviate the limitations in blood supply. |
| format | Article |
| id | doaj-art-83c9bf04431e40da82cd17bc3d4061e5 |
| institution | Kabale University |
| issn | 2306-5354 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj-art-83c9bf04431e40da82cd17bc3d4061e52025-08-20T03:43:21ZengMDPI AGBioengineering2306-53542025-03-0112325610.3390/bioengineering12030256Progress in Development of Functional Biological and Synthetic Blood Products to Augment Transfusable Blood Supply in Operational MedicineArmando Estrada0Orion Furmanski1George J. Klarmann2Nathan Scheidt3Vincent B. Ho44D Bio<sup>3</sup> Center for Biotechnology, Department of Radiology and Bioengineering, Uniformed Services University of the Health Sciences, Rockville, MD 20850, USA4D Bio<sup>3</sup> Center for Biotechnology, Department of Radiology and Bioengineering, Uniformed Services University of the Health Sciences, Rockville, MD 20850, USA4D Bio<sup>3</sup> Center for Biotechnology, Department of Radiology and Bioengineering, Uniformed Services University of the Health Sciences, Rockville, MD 20850, USAThe United States Air Force Academy, USAF Academy, CO 80840, USA4D Bio<sup>3</sup> Center for Biotechnology, Department of Radiology and Bioengineering, Uniformed Services University of the Health Sciences, Rockville, MD 20850, USAA reliable, accessible, and high-quality blood supply is critical for the sustainment of any healthcare system. World events such as the COVID-19 pandemic have proven that maintaining the supply of blood presents a logistical challenge. The current blood supply is overseen by extensive donor programs around the world. In the United States, as in other countries, the need for blood has increased, with a decline in blood donations and increasing exclusions for blood donor qualification. While there is a need to improve blood donation participation, there is also need for new alternatives to traditional donation to ensure readiness to treat hemorrhagic shock common in the setting of trauma, as often occurs during a natural disaster or conflict. These operational medicine scenarios require significant blood availability which may tax the current blood supply chain. Aside from a walking blood bank (WBB) model for blood collection in suboptimal conditions, researchers have proposed alternatives for blood that include the manufacturing of blood from stem cell sources. Other alternatives include synthetic liquids that can carry oxygen such as Perfluoro-Chemicals (PFCs) and hemoglobin-based oxygen-carrying systems (HBCOs). Here, we review some of these alternatives to the traditional donor blood model. Researchers now have the technology that makes it feasible to develop blood alternatives that one day may supplement and help alleviate the limitations in blood supply.https://www.mdpi.com/2306-5354/12/3/256erythrocytered blood celltransfusionhemoglobinsyntheticerythropoiesis |
| spellingShingle | Armando Estrada Orion Furmanski George J. Klarmann Nathan Scheidt Vincent B. Ho Progress in Development of Functional Biological and Synthetic Blood Products to Augment Transfusable Blood Supply in Operational Medicine Bioengineering erythrocyte red blood cell transfusion hemoglobin synthetic erythropoiesis |
| title | Progress in Development of Functional Biological and Synthetic Blood Products to Augment Transfusable Blood Supply in Operational Medicine |
| title_full | Progress in Development of Functional Biological and Synthetic Blood Products to Augment Transfusable Blood Supply in Operational Medicine |
| title_fullStr | Progress in Development of Functional Biological and Synthetic Blood Products to Augment Transfusable Blood Supply in Operational Medicine |
| title_full_unstemmed | Progress in Development of Functional Biological and Synthetic Blood Products to Augment Transfusable Blood Supply in Operational Medicine |
| title_short | Progress in Development of Functional Biological and Synthetic Blood Products to Augment Transfusable Blood Supply in Operational Medicine |
| title_sort | progress in development of functional biological and synthetic blood products to augment transfusable blood supply in operational medicine |
| topic | erythrocyte red blood cell transfusion hemoglobin synthetic erythropoiesis |
| url | https://www.mdpi.com/2306-5354/12/3/256 |
| work_keys_str_mv | AT armandoestrada progressindevelopmentoffunctionalbiologicalandsyntheticbloodproductstoaugmenttransfusablebloodsupplyinoperationalmedicine AT orionfurmanski progressindevelopmentoffunctionalbiologicalandsyntheticbloodproductstoaugmenttransfusablebloodsupplyinoperationalmedicine AT georgejklarmann progressindevelopmentoffunctionalbiologicalandsyntheticbloodproductstoaugmenttransfusablebloodsupplyinoperationalmedicine AT nathanscheidt progressindevelopmentoffunctionalbiologicalandsyntheticbloodproductstoaugmenttransfusablebloodsupplyinoperationalmedicine AT vincentbho progressindevelopmentoffunctionalbiologicalandsyntheticbloodproductstoaugmenttransfusablebloodsupplyinoperationalmedicine |