Association between neutrophil-to-high-density lipoprotein cholesterol ratio and non-alcoholic fatty liver disease or metabolic dysfunction-associated steatotic liver disease: evidence from NHANES 2017–2020
BackgroundNon-alcoholic fatty liver disease (NAFLD) or metabolic dysfunction-associated steatotic liver disease (MASLD) is closely associated with chronic inflammation and lipid metabolism disorders. The neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) is an integrative marker reflecti...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1491858/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841527836928638976 |
|---|---|
| author | Na Zhu Yanyan Li Yingying Lin XinYu Cui Xin Li Xin Li |
| author_facet | Na Zhu Yanyan Li Yingying Lin XinYu Cui Xin Li Xin Li |
| author_sort | Na Zhu |
| collection | DOAJ |
| description | BackgroundNon-alcoholic fatty liver disease (NAFLD) or metabolic dysfunction-associated steatotic liver disease (MASLD) is closely associated with chronic inflammation and lipid metabolism disorders. The neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) is an integrative marker reflecting inflammatory responses and lipid metabolism disorders and is associated with various diseases. This cross-sectional study aimed to determine the association between NHR and NAFLD, MASLD, and liver fibrosis.MethodsData for this study were obtained from the 2017–2020 National Health and Nutrition Examination Survey (NHANES), we employed weighted multiple regression and restricted cubic spline (RCS) analysis to assess the relationship between NHR and NAFLD, MASLD, and liver fibrosis. Additionally, we performed stratified analyses based on gender, age, body mass index, diabetes, hypertension, smoking status, and history of cardiovascular disease to evaluate the consistency of these associations across different subgroups.ResultsA total of 6,526 participants were included in the study. 2,839 (weighted 44.1%) participants were diagnosed with NAFLD and 2,813 (weighted 43.7%) participants were diagnosed with MASLD. After adjusting for confounders, NHR was positively associated with the risk of NAFLD/MASLD, and the correlation was particularly significant in the subgroups of females, those without hypertension, and those without diabetes (p < 0.05). By the NHR quartile, the risk of NAFLD/MASLD increased progressively with higher NHR levels (P for trend <0.001). In addition, RCS analysis showed a nonlinear association between NHR and NAFLD/MASLD and liver fibrosis (P-non-linear <0.05).ConclusionNHR may serve as a potential marker for NAFLD/MASLD and liver fibrosis, and lowering NHR levels could help reduce the incidence of these conditions. |
| format | Article |
| id | doaj-art-83a26c0ea9bc44ce9721f9f835adb430 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-83a26c0ea9bc44ce9721f9f835adb4302025-01-15T06:10:34ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011110.3389/fmed.2024.14918581491858Association between neutrophil-to-high-density lipoprotein cholesterol ratio and non-alcoholic fatty liver disease or metabolic dysfunction-associated steatotic liver disease: evidence from NHANES 2017–2020Na Zhu0Yanyan Li1Yingying Lin2XinYu Cui3Xin Li4Xin Li5Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaCenter of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaCenter of Integrative Medicine, Peking University Ditan Teaching Hospital, Beijing, ChinaCenter of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaCenter of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, ChinaCenter of Integrative Medicine, Peking University Ditan Teaching Hospital, Beijing, ChinaBackgroundNon-alcoholic fatty liver disease (NAFLD) or metabolic dysfunction-associated steatotic liver disease (MASLD) is closely associated with chronic inflammation and lipid metabolism disorders. The neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) is an integrative marker reflecting inflammatory responses and lipid metabolism disorders and is associated with various diseases. This cross-sectional study aimed to determine the association between NHR and NAFLD, MASLD, and liver fibrosis.MethodsData for this study were obtained from the 2017–2020 National Health and Nutrition Examination Survey (NHANES), we employed weighted multiple regression and restricted cubic spline (RCS) analysis to assess the relationship between NHR and NAFLD, MASLD, and liver fibrosis. Additionally, we performed stratified analyses based on gender, age, body mass index, diabetes, hypertension, smoking status, and history of cardiovascular disease to evaluate the consistency of these associations across different subgroups.ResultsA total of 6,526 participants were included in the study. 2,839 (weighted 44.1%) participants were diagnosed with NAFLD and 2,813 (weighted 43.7%) participants were diagnosed with MASLD. After adjusting for confounders, NHR was positively associated with the risk of NAFLD/MASLD, and the correlation was particularly significant in the subgroups of females, those without hypertension, and those without diabetes (p < 0.05). By the NHR quartile, the risk of NAFLD/MASLD increased progressively with higher NHR levels (P for trend <0.001). In addition, RCS analysis showed a nonlinear association between NHR and NAFLD/MASLD and liver fibrosis (P-non-linear <0.05).ConclusionNHR may serve as a potential marker for NAFLD/MASLD and liver fibrosis, and lowering NHR levels could help reduce the incidence of these conditions.https://www.frontiersin.org/articles/10.3389/fmed.2024.1491858/fullnon-alcoholic fatty liver diseasemetabolic dysfunction-associated steatotic liver diseaseneutrophil-to-high-density lipoprotein cholesterol ratioinflammationlipid metabolism disordersliver fibrosis |
| spellingShingle | Na Zhu Yanyan Li Yingying Lin XinYu Cui Xin Li Xin Li Association between neutrophil-to-high-density lipoprotein cholesterol ratio and non-alcoholic fatty liver disease or metabolic dysfunction-associated steatotic liver disease: evidence from NHANES 2017–2020 Frontiers in Medicine non-alcoholic fatty liver disease metabolic dysfunction-associated steatotic liver disease neutrophil-to-high-density lipoprotein cholesterol ratio inflammation lipid metabolism disorders liver fibrosis |
| title | Association between neutrophil-to-high-density lipoprotein cholesterol ratio and non-alcoholic fatty liver disease or metabolic dysfunction-associated steatotic liver disease: evidence from NHANES 2017–2020 |
| title_full | Association between neutrophil-to-high-density lipoprotein cholesterol ratio and non-alcoholic fatty liver disease or metabolic dysfunction-associated steatotic liver disease: evidence from NHANES 2017–2020 |
| title_fullStr | Association between neutrophil-to-high-density lipoprotein cholesterol ratio and non-alcoholic fatty liver disease or metabolic dysfunction-associated steatotic liver disease: evidence from NHANES 2017–2020 |
| title_full_unstemmed | Association between neutrophil-to-high-density lipoprotein cholesterol ratio and non-alcoholic fatty liver disease or metabolic dysfunction-associated steatotic liver disease: evidence from NHANES 2017–2020 |
| title_short | Association between neutrophil-to-high-density lipoprotein cholesterol ratio and non-alcoholic fatty liver disease or metabolic dysfunction-associated steatotic liver disease: evidence from NHANES 2017–2020 |
| title_sort | association between neutrophil to high density lipoprotein cholesterol ratio and non alcoholic fatty liver disease or metabolic dysfunction associated steatotic liver disease evidence from nhanes 2017 2020 |
| topic | non-alcoholic fatty liver disease metabolic dysfunction-associated steatotic liver disease neutrophil-to-high-density lipoprotein cholesterol ratio inflammation lipid metabolism disorders liver fibrosis |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1491858/full |
| work_keys_str_mv | AT nazhu associationbetweenneutrophiltohighdensitylipoproteincholesterolratioandnonalcoholicfattyliverdiseaseormetabolicdysfunctionassociatedsteatoticliverdiseaseevidencefromnhanes20172020 AT yanyanli associationbetweenneutrophiltohighdensitylipoproteincholesterolratioandnonalcoholicfattyliverdiseaseormetabolicdysfunctionassociatedsteatoticliverdiseaseevidencefromnhanes20172020 AT yingyinglin associationbetweenneutrophiltohighdensitylipoproteincholesterolratioandnonalcoholicfattyliverdiseaseormetabolicdysfunctionassociatedsteatoticliverdiseaseevidencefromnhanes20172020 AT xinyucui associationbetweenneutrophiltohighdensitylipoproteincholesterolratioandnonalcoholicfattyliverdiseaseormetabolicdysfunctionassociatedsteatoticliverdiseaseevidencefromnhanes20172020 AT xinli associationbetweenneutrophiltohighdensitylipoproteincholesterolratioandnonalcoholicfattyliverdiseaseormetabolicdysfunctionassociatedsteatoticliverdiseaseevidencefromnhanes20172020 AT xinli associationbetweenneutrophiltohighdensitylipoproteincholesterolratioandnonalcoholicfattyliverdiseaseormetabolicdysfunctionassociatedsteatoticliverdiseaseevidencefromnhanes20172020 |