Isolated from Antrodia cinnamomea, 25S-antcin K suppresses the production of inflammatory cytokines and cartilage degradation in rheumatoid arthritis
Rheumatoid arthritis (RA) is a well-known autoimmune disorder associated with joint pain, swelling, cartilage and bone degradation, as well as deformity. In cellular and animal model investigations, extracts from Antrodia cinnamomea, a traditional medicinal fungus used in Taiwan, demonstrate anti-in...
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Elsevier
2024-11-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624004754 |
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| author | Shan-Chi Liu Tung-Ying Wu Trung-Loc Ho Chun-Hao Tsai Wen-Hui Chung Yen-You Lin Yang-Chang Wu Chih-Hsin Tang |
| author_facet | Shan-Chi Liu Tung-Ying Wu Trung-Loc Ho Chun-Hao Tsai Wen-Hui Chung Yen-You Lin Yang-Chang Wu Chih-Hsin Tang |
| author_sort | Shan-Chi Liu |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is a well-known autoimmune disorder associated with joint pain, swelling, cartilage and bone degradation, as well as deformity. In cellular and animal model investigations, extracts from Antrodia cinnamomea, a traditional medicinal fungus used in Taiwan, demonstrate anti-inflammatory properties. The 25(S) ergostane stereo-isomer of antcin K, known as 25S-antcin K, was previously isolated from A. cinnamomea and was found to exhibit a more potent effect than antcin K. In the current study, we examined the anti-RA effects of 25S-antcin K. 25S-antcin K abolishes IL-1β-induced promotion of TNF-α, CCL2, and VEGF arthritic factors production by inhibiting AMPK, Akt, and p38 pathways and enhancing miR-374b expression. Importantly, administration of 25S-antcin K also antagonizes collagen-induced arthritis-induced RA symptoms, such as inflammation, cartilage degradation, and bone erosion in vivo. These results provide a novel avenue, suggesting that 25S-antcin K is a potential candidate for developing RA therapy agents. |
| format | Article |
| id | doaj-art-838d8bdd515e423fbed0f7fc088e277f |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-838d8bdd515e423fbed0f7fc088e277f2024-11-16T05:10:35ZengElsevierJournal of Functional Foods1756-46462024-11-01122106473Isolated from Antrodia cinnamomea, 25S-antcin K suppresses the production of inflammatory cytokines and cartilage degradation in rheumatoid arthritisShan-Chi Liu0Tung-Ying Wu1Trung-Loc Ho2Chun-Hao Tsai3Wen-Hui Chung4Yen-You Lin5Yang-Chang Wu6Chih-Hsin Tang7Institute of Biomedical Sciences, Mackay Medical College, New Taipei City, TaiwanDepartment of Food Science and Nutrition, Meiho University, Pingtung, TaiwanGraduate Institute of Biomedical Science, China Medical University, Taichung, TaiwanDepartment of Sports Medicine, College of Health Care, China Medical University, Taichung, Taiwan; Department of Orthopedic Surgery, China Medical University Hospital, Taichung, TaiwanDepartment of Pharmacology, School of Medicine, China Medical University, Taichung, TaiwanDepartment of Pharmacology, School of Medicine, China Medical University, Taichung, TaiwanChinese Medicine Research and Development Center, China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan; Corresponding authors.Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan; Department of Pharmacology, School of Medicine, China Medical University, Taichung, Taiwan; Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung, Taiwan; Chinese Medicine Research Center, China Medical University, Taichung, Taiwan; Department of Medical Research, China Medical University Hsinchu Hospital, Hsinchu, Taiwan; Corresponding authors.Rheumatoid arthritis (RA) is a well-known autoimmune disorder associated with joint pain, swelling, cartilage and bone degradation, as well as deformity. In cellular and animal model investigations, extracts from Antrodia cinnamomea, a traditional medicinal fungus used in Taiwan, demonstrate anti-inflammatory properties. The 25(S) ergostane stereo-isomer of antcin K, known as 25S-antcin K, was previously isolated from A. cinnamomea and was found to exhibit a more potent effect than antcin K. In the current study, we examined the anti-RA effects of 25S-antcin K. 25S-antcin K abolishes IL-1β-induced promotion of TNF-α, CCL2, and VEGF arthritic factors production by inhibiting AMPK, Akt, and p38 pathways and enhancing miR-374b expression. Importantly, administration of 25S-antcin K also antagonizes collagen-induced arthritis-induced RA symptoms, such as inflammation, cartilage degradation, and bone erosion in vivo. These results provide a novel avenue, suggesting that 25S-antcin K is a potential candidate for developing RA therapy agents.http://www.sciencedirect.com/science/article/pii/S1756464624004754Rheumatoid arthritisAntrodia cinnamomea25S-antcin KmiR-374bSynovial fibroblasts |
| spellingShingle | Shan-Chi Liu Tung-Ying Wu Trung-Loc Ho Chun-Hao Tsai Wen-Hui Chung Yen-You Lin Yang-Chang Wu Chih-Hsin Tang Isolated from Antrodia cinnamomea, 25S-antcin K suppresses the production of inflammatory cytokines and cartilage degradation in rheumatoid arthritis Journal of Functional Foods Rheumatoid arthritis Antrodia cinnamomea 25S-antcin K miR-374b Synovial fibroblasts |
| title | Isolated from Antrodia cinnamomea, 25S-antcin K suppresses the production of inflammatory cytokines and cartilage degradation in rheumatoid arthritis |
| title_full | Isolated from Antrodia cinnamomea, 25S-antcin K suppresses the production of inflammatory cytokines and cartilage degradation in rheumatoid arthritis |
| title_fullStr | Isolated from Antrodia cinnamomea, 25S-antcin K suppresses the production of inflammatory cytokines and cartilage degradation in rheumatoid arthritis |
| title_full_unstemmed | Isolated from Antrodia cinnamomea, 25S-antcin K suppresses the production of inflammatory cytokines and cartilage degradation in rheumatoid arthritis |
| title_short | Isolated from Antrodia cinnamomea, 25S-antcin K suppresses the production of inflammatory cytokines and cartilage degradation in rheumatoid arthritis |
| title_sort | isolated from antrodia cinnamomea 25s antcin k suppresses the production of inflammatory cytokines and cartilage degradation in rheumatoid arthritis |
| topic | Rheumatoid arthritis Antrodia cinnamomea 25S-antcin K miR-374b Synovial fibroblasts |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624004754 |
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