Endothelial-specific deletion of connexin 43 improves renal function and structure after acute kidney injury

Endothelial-specific deletion of connexin 43 improves renal function and structure after acute kidney injury

Abstract Background We have previously reported that the gap junction protein connexin 43 (Cx43) was upregulated in chronic renal disease in humans and rodents and plays a crucial role in the progression of experimental nephropathy. In this study, we investigated its role after renal ischemia/reperf...

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Main Authors: Magali Genest, Satoshi Kinugasa, Elena Roger, Louis Boutin, Sandrine Placier, Stefanny Figueroa, Aude Dorison, Safia Hadjadj, Ines Baba, Emmanuel L. Gautier, Panagiotis Kavvadas, Christos Chatziantoniou, Christos E. Chadjichristos
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Molecular Medicine
Subjects:
Connexin 43
Inflammation
Acute kidney injury
Online Access:https://doi.org/10.1186/s10020-024-01011-6
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