Antibiotic prophylaxis for head and neck cancer surgery
This review analyzes the research data concerning the problem of antibiotic prophylaxis (ABP) of wound infections after various surgeries for head and neck tumors. In patients with clean wounds, ABP should be used in exceptional cases only (for example, if the patient has any risk factors), otherwis...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2020-07-01
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| Series: | Опухоли головы и шеи |
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| Online Access: | https://ogsh.abvpress.ru/jour/article/view/527 |
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| author | A. O. Guz D. M. Fatkullin A. V. Garev A. S. Zakharov M. I. Sokolova A. P. Alekseeva |
| author_facet | A. O. Guz D. M. Fatkullin A. V. Garev A. S. Zakharov M. I. Sokolova A. P. Alekseeva |
| author_sort | A. O. Guz |
| collection | DOAJ |
| description | This review analyzes the research data concerning the problem of antibiotic prophylaxis (ABP) of wound infections after various surgeries for head and neck tumors. In patients with clean wounds, ABP should be used in exceptional cases only (for example, if the patient has any risk factors), otherwise it should be avoided. A short ABP course is recommended for patients with clean-contaminated wounds; however highrisk patients may require a prolonged course. There is some evidence of ABP efficacy in patients with non-contaminated wounds after cervical lymphadenectomy. When choosing a drug for ABP, a doctor should consider the site of surgery and the risk of wound contamination. The optimal drugs after head and neck surgeries include first- and second-generation cephalosporins, ampicillin in combination with sulbactam, metronidazole, and clindamycin. First- and second-generation cephalosporins in combination with metronidazole are preferable, but if the wound is infected with gram-positive bacteria, it is necessary to use clindamycin monotherapy. Reconstructive surgeries with a free flap require a short course of ABP with one of the following combinations: cefazolin + metronidazole, cefuroxime + metronidazole, or ampicillin + sulbactam; if the patient is allergic to beta-lactams, clindamycin can be used. Despite the availability of standard ABP regimens, a surgeon must apply a tailored approach when choosing an ABP regimen for each patient, taking into account risk factors and the volume of surgery. |
| format | Article |
| id | doaj-art-8380f03a6f00428ebe9d63d2e29cff7f |
| institution | Kabale University |
| issn | 2222-1468 2411-4634 |
| language | Russian |
| publishDate | 2020-07-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли головы и шеи |
| spelling | doaj-art-8380f03a6f00428ebe9d63d2e29cff7f2025-08-20T03:59:48ZrusABV-pressОпухоли головы и шеи2222-14682411-46342020-07-01102546010.17650/2222-1468-2020-10-2-54-60393Antibiotic prophylaxis for head and neck cancer surgeryA. O. Guz0D. M. Fatkullin1A. V. Garev2A. S. Zakharov3M. I. Sokolova4A. P. Alekseeva5Chelyabinsk Regional Clinical Center of Oncology and Nuclear MedicineChelyabinsk Regional Clinical Center of Oncology and Nuclear MedicineChelyabinsk Regional Clinical Center of Oncology and Nuclear MedicineChelyabinsk Regional Clinical Center of Oncology and Nuclear MedicineChelyabinsk Regional Clinical Center of Oncology and Nuclear MedicineChelyabinsk Regional Clinical Center of Oncology and Nuclear MedicineThis review analyzes the research data concerning the problem of antibiotic prophylaxis (ABP) of wound infections after various surgeries for head and neck tumors. In patients with clean wounds, ABP should be used in exceptional cases only (for example, if the patient has any risk factors), otherwise it should be avoided. A short ABP course is recommended for patients with clean-contaminated wounds; however highrisk patients may require a prolonged course. There is some evidence of ABP efficacy in patients with non-contaminated wounds after cervical lymphadenectomy. When choosing a drug for ABP, a doctor should consider the site of surgery and the risk of wound contamination. The optimal drugs after head and neck surgeries include first- and second-generation cephalosporins, ampicillin in combination with sulbactam, metronidazole, and clindamycin. First- and second-generation cephalosporins in combination with metronidazole are preferable, but if the wound is infected with gram-positive bacteria, it is necessary to use clindamycin monotherapy. Reconstructive surgeries with a free flap require a short course of ABP with one of the following combinations: cefazolin + metronidazole, cefuroxime + metronidazole, or ampicillin + sulbactam; if the patient is allergic to beta-lactams, clindamycin can be used. Despite the availability of standard ABP regimens, a surgeon must apply a tailored approach when choosing an ABP regimen for each patient, taking into account risk factors and the volume of surgery.https://ogsh.abvpress.ru/jour/article/view/527head and neck tumorsantibiotic prophylaxissurgical wound infectionclean woundsclean-contaminated woundslymphadenectomyfree flapcephalosporinsclindamycin |
| spellingShingle | A. O. Guz D. M. Fatkullin A. V. Garev A. S. Zakharov M. I. Sokolova A. P. Alekseeva Antibiotic prophylaxis for head and neck cancer surgery Опухоли головы и шеи head and neck tumors antibiotic prophylaxis surgical wound infection clean wounds clean-contaminated wounds lymphadenectomy free flap cephalosporins clindamycin |
| title | Antibiotic prophylaxis for head and neck cancer surgery |
| title_full | Antibiotic prophylaxis for head and neck cancer surgery |
| title_fullStr | Antibiotic prophylaxis for head and neck cancer surgery |
| title_full_unstemmed | Antibiotic prophylaxis for head and neck cancer surgery |
| title_short | Antibiotic prophylaxis for head and neck cancer surgery |
| title_sort | antibiotic prophylaxis for head and neck cancer surgery |
| topic | head and neck tumors antibiotic prophylaxis surgical wound infection clean wounds clean-contaminated wounds lymphadenectomy free flap cephalosporins clindamycin |
| url | https://ogsh.abvpress.ru/jour/article/view/527 |
| work_keys_str_mv | AT aoguz antibioticprophylaxisforheadandneckcancersurgery AT dmfatkullin antibioticprophylaxisforheadandneckcancersurgery AT avgarev antibioticprophylaxisforheadandneckcancersurgery AT aszakharov antibioticprophylaxisforheadandneckcancersurgery AT misokolova antibioticprophylaxisforheadandneckcancersurgery AT apalekseeva antibioticprophylaxisforheadandneckcancersurgery |