A potential therapeutic approach for ulcerative colitis: targeted regulation of mitochondrial dynamics and mitophagy through phytochemicals
Mitochondria are important organelles that regulate cellular energy and biosynthesis, as well as maintain the body’s response to environmental stress. Their dynamics and autophagy influence occurrence of cellular function, particularly under stressful conditions. They can generate reactive oxygen sp...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1506292/full |
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| author | Jianping Zhou Yuting Xi Ting Wu Xiaoyu Zeng Jun Yuan Lei Peng Hao Fu Ce Zhou |
| author_facet | Jianping Zhou Yuting Xi Ting Wu Xiaoyu Zeng Jun Yuan Lei Peng Hao Fu Ce Zhou |
| author_sort | Jianping Zhou |
| collection | DOAJ |
| description | Mitochondria are important organelles that regulate cellular energy and biosynthesis, as well as maintain the body’s response to environmental stress. Their dynamics and autophagy influence occurrence of cellular function, particularly under stressful conditions. They can generate reactive oxygen species (ROS) which is a major contributor to inflammatory diseases such as ulcerative colitis (UC). In this review, we discuss the key effects of mitochondrial dynamics and mitophagy on the pathogenesis of UC, with a particular focus on the cellular energy metabolism, oxidative stress, apoptosis, and immunoinflammatory activities. The therapeutic efficacy of existing drugs and phytochemicals targeting the mitochondrial pathway are discussed to reveal important insights for developing therapeutic strategies for treating UC. In addition, new molecular checkpoints with therapeutic potential are identified. We show that the integration of mitochondrial biology with the clinical aspects of UC may generate ideas for enhancing the clinical management of UC. |
| format | Article |
| id | doaj-art-833ec40d933a4533bc3d7d0fbdbf4425 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-833ec40d933a4533bc3d7d0fbdbf44252025-01-07T06:49:05ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.15062921506292A potential therapeutic approach for ulcerative colitis: targeted regulation of mitochondrial dynamics and mitophagy through phytochemicalsJianping Zhou0Yuting Xi1Ting Wu2Xiaoyu Zeng3Jun Yuan4Lei Peng5Hao Fu6Ce Zhou7Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaZigong Hospital of Traditional Chinese Medicine, Zigong, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaMitochondria are important organelles that regulate cellular energy and biosynthesis, as well as maintain the body’s response to environmental stress. Their dynamics and autophagy influence occurrence of cellular function, particularly under stressful conditions. They can generate reactive oxygen species (ROS) which is a major contributor to inflammatory diseases such as ulcerative colitis (UC). In this review, we discuss the key effects of mitochondrial dynamics and mitophagy on the pathogenesis of UC, with a particular focus on the cellular energy metabolism, oxidative stress, apoptosis, and immunoinflammatory activities. The therapeutic efficacy of existing drugs and phytochemicals targeting the mitochondrial pathway are discussed to reveal important insights for developing therapeutic strategies for treating UC. In addition, new molecular checkpoints with therapeutic potential are identified. We show that the integration of mitochondrial biology with the clinical aspects of UC may generate ideas for enhancing the clinical management of UC.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1506292/fullUCmitochondrial dynamicsmitophagytargeted therapynature products |
| spellingShingle | Jianping Zhou Yuting Xi Ting Wu Xiaoyu Zeng Jun Yuan Lei Peng Hao Fu Ce Zhou A potential therapeutic approach for ulcerative colitis: targeted regulation of mitochondrial dynamics and mitophagy through phytochemicals Frontiers in Immunology UC mitochondrial dynamics mitophagy targeted therapy nature products |
| title | A potential therapeutic approach for ulcerative colitis: targeted regulation of mitochondrial dynamics and mitophagy through phytochemicals |
| title_full | A potential therapeutic approach for ulcerative colitis: targeted regulation of mitochondrial dynamics and mitophagy through phytochemicals |
| title_fullStr | A potential therapeutic approach for ulcerative colitis: targeted regulation of mitochondrial dynamics and mitophagy through phytochemicals |
| title_full_unstemmed | A potential therapeutic approach for ulcerative colitis: targeted regulation of mitochondrial dynamics and mitophagy through phytochemicals |
| title_short | A potential therapeutic approach for ulcerative colitis: targeted regulation of mitochondrial dynamics and mitophagy through phytochemicals |
| title_sort | potential therapeutic approach for ulcerative colitis targeted regulation of mitochondrial dynamics and mitophagy through phytochemicals |
| topic | UC mitochondrial dynamics mitophagy targeted therapy nature products |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1506292/full |
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