Lipid metabolism in age-related musculoskeletal disorders: insights into sarcopenia and osteoporosis
Abstract Musculoskeletal disorders (MSDs), notably sarcopenia and osteoporosis, profoundly affect aging individuals. This review explores lipid metabolism's role in age-related MSD pathophysiology, highlighting fatty acid uptake, lipid signaling, and lipotoxicity in muscle deterioration. It fur...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-08-01
|
| Series: | BMC Biology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12915-025-02383-9 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849225921281654784 |
|---|---|
| author | Shivum Lal Shreya Gunji Pankaj Ahluwalia Ravindra Kolhe Wendy B. Bollag William D. Hill Meghan E. McGee-Lawrence Carlos M. Isales Sadanand Fulzele |
| author_facet | Shivum Lal Shreya Gunji Pankaj Ahluwalia Ravindra Kolhe Wendy B. Bollag William D. Hill Meghan E. McGee-Lawrence Carlos M. Isales Sadanand Fulzele |
| author_sort | Shivum Lal |
| collection | DOAJ |
| description | Abstract Musculoskeletal disorders (MSDs), notably sarcopenia and osteoporosis, profoundly affect aging individuals. This review explores lipid metabolism's role in age-related MSD pathophysiology, highlighting fatty acid uptake, lipid signaling, and lipotoxicity in muscle deterioration. It further addresses lipid-mediated regulation of osteoclasts, osteoblasts, and bone remodeling, emphasizing age-associated metabolic shifts exacerbating bone loss. Emerging therapeutic strategies targeting lipid pathways for MSD treatment are also discussed. This review integrates recent findings in muscle and bone lipid metabolism to deepen understanding of lipid dysregulation in musculoskeletal disorders and explore potential metabolic intervention strategies. |
| format | Article |
| id | doaj-art-832a41f8464c4c7a8e90770e42c09e51 |
| institution | Kabale University |
| issn | 1741-7007 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Biology |
| spelling | doaj-art-832a41f8464c4c7a8e90770e42c09e512025-08-24T11:50:26ZengBMCBMC Biology1741-70072025-08-0123111810.1186/s12915-025-02383-9Lipid metabolism in age-related musculoskeletal disorders: insights into sarcopenia and osteoporosisShivum Lal0Shreya Gunji1Pankaj Ahluwalia2Ravindra Kolhe3Wendy B. Bollag4William D. Hill5Meghan E. McGee-Lawrence6Carlos M. Isales7Sadanand Fulzele8Department of Medicine, Augusta UniversityDepartment of Medicine, Augusta UniversityDepartment of Pathology, Augusta UniversityDepartment of Pathology, Augusta UniversityDepartment of Physiology and Endocrinology, Augusta UniversityMedical University of South CarolinaDepartment of Cellular Biology and Anatomy, Augusta UniversityDepartment of Medicine, Augusta UniversityDepartment of Medicine, Augusta UniversityAbstract Musculoskeletal disorders (MSDs), notably sarcopenia and osteoporosis, profoundly affect aging individuals. This review explores lipid metabolism's role in age-related MSD pathophysiology, highlighting fatty acid uptake, lipid signaling, and lipotoxicity in muscle deterioration. It further addresses lipid-mediated regulation of osteoclasts, osteoblasts, and bone remodeling, emphasizing age-associated metabolic shifts exacerbating bone loss. Emerging therapeutic strategies targeting lipid pathways for MSD treatment are also discussed. This review integrates recent findings in muscle and bone lipid metabolism to deepen understanding of lipid dysregulation in musculoskeletal disorders and explore potential metabolic intervention strategies.https://doi.org/10.1186/s12915-025-02383-9Lipid MetabolismAgingMusculoskeletalSarcopeniaOsteoporosis |
| spellingShingle | Shivum Lal Shreya Gunji Pankaj Ahluwalia Ravindra Kolhe Wendy B. Bollag William D. Hill Meghan E. McGee-Lawrence Carlos M. Isales Sadanand Fulzele Lipid metabolism in age-related musculoskeletal disorders: insights into sarcopenia and osteoporosis BMC Biology Lipid Metabolism Aging Musculoskeletal Sarcopenia Osteoporosis |
| title | Lipid metabolism in age-related musculoskeletal disorders: insights into sarcopenia and osteoporosis |
| title_full | Lipid metabolism in age-related musculoskeletal disorders: insights into sarcopenia and osteoporosis |
| title_fullStr | Lipid metabolism in age-related musculoskeletal disorders: insights into sarcopenia and osteoporosis |
| title_full_unstemmed | Lipid metabolism in age-related musculoskeletal disorders: insights into sarcopenia and osteoporosis |
| title_short | Lipid metabolism in age-related musculoskeletal disorders: insights into sarcopenia and osteoporosis |
| title_sort | lipid metabolism in age related musculoskeletal disorders insights into sarcopenia and osteoporosis |
| topic | Lipid Metabolism Aging Musculoskeletal Sarcopenia Osteoporosis |
| url | https://doi.org/10.1186/s12915-025-02383-9 |
| work_keys_str_mv | AT shivumlal lipidmetabolisminagerelatedmusculoskeletaldisordersinsightsintosarcopeniaandosteoporosis AT shreyagunji lipidmetabolisminagerelatedmusculoskeletaldisordersinsightsintosarcopeniaandosteoporosis AT pankajahluwalia lipidmetabolisminagerelatedmusculoskeletaldisordersinsightsintosarcopeniaandosteoporosis AT ravindrakolhe lipidmetabolisminagerelatedmusculoskeletaldisordersinsightsintosarcopeniaandosteoporosis AT wendybbollag lipidmetabolisminagerelatedmusculoskeletaldisordersinsightsintosarcopeniaandosteoporosis AT williamdhill lipidmetabolisminagerelatedmusculoskeletaldisordersinsightsintosarcopeniaandosteoporosis AT meghanemcgeelawrence lipidmetabolisminagerelatedmusculoskeletaldisordersinsightsintosarcopeniaandosteoporosis AT carlosmisales lipidmetabolisminagerelatedmusculoskeletaldisordersinsightsintosarcopeniaandosteoporosis AT sadanandfulzele lipidmetabolisminagerelatedmusculoskeletaldisordersinsightsintosarcopeniaandosteoporosis |