Avelumab induces greater Fc-Fc receptor-dependent natural killer cell activation and dendritic cell crosstalk compared to durvalumab

Avelumab induces greater Fc-Fc receptor-dependent natural killer cell activation and dendritic cell crosstalk compared to durvalumab

Several FDA-approved anti-PD-L1 (programmed cell death ligand-1) monoclonal antibodies (mAbs) are used to treat cancer. While these mAbs primarily target and intercept PD-L1:PD-1 inhibitory signaling in T-cells, the Fc-domains of these mAbs are distinct, and the unique cellular cascades triggered by...

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Bibliographic Details
Main Authors: Nicole Osborne, Amit Rupani, Vladimir Makarov, Timothy A. Chan, Raghvendra M. Srivastava
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:OncoImmunology
Subjects:
ADCC
dendritic cell maturation
Fc-domain
FCGR
IgG1
immune crosstalk
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2025.2494995
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