Liver transplantation for primary biliary cholangitis (review)
Primary biliary cholangitis (PBC) is an autoimmune liver disease resulting from the destruction and inflammation of intrahepatic bile ducts. This end-stage disease was once the most common cause of liver transplantation. The use of ursodeoxycholic and obeticholic acids as a first-line and second-lin...
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2022-04-01
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| Series: | Вестник трансплантологии и искусственных органов |
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| Online Access: | https://journal.transpl.ru/vtio/article/view/1469 |
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| _version_ | 1849242225356046336 |
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| author | I. M. Iljinsky O. M. Tsirulnikova |
| author_facet | I. M. Iljinsky O. M. Tsirulnikova |
| author_sort | I. M. Iljinsky |
| collection | DOAJ |
| description | Primary biliary cholangitis (PBC) is an autoimmune liver disease resulting from the destruction and inflammation of intrahepatic bile ducts. This end-stage disease was once the most common cause of liver transplantation. The use of ursodeoxycholic and obeticholic acids as a first-line and second-line treatment, respectively, slows down the disease. However, treatment is not effective in about 40% of PBC patients, and the disease may progress to cirrhosis and end-stage liver disease. These patients undergo liver transplantation to save their lives. After surgery, recurrent PBC can develop in a milder form and rarely requires liver retransplantation. |
| format | Article |
| id | doaj-art-831687cf70d44bcaba23d003d2e9966a |
| institution | Kabale University |
| issn | 1995-1191 |
| language | Russian |
| publishDate | 2022-04-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Вестник трансплантологии и искусственных органов |
| spelling | doaj-art-831687cf70d44bcaba23d003d2e9966a2025-08-20T03:59:53ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovВестник трансплантологии и искусственных органов1995-11912022-04-01241152210.15825/1995-1191-2022-1-15-221086Liver transplantation for primary biliary cholangitis (review)I. M. Iljinsky0O. M. Tsirulnikova1Shumakov National Medical Research Center of Transplantology and Artificial OrgansShumakov National Medical Research Center of Transplantology and Artificial Organs; Sechenov UniversityPrimary biliary cholangitis (PBC) is an autoimmune liver disease resulting from the destruction and inflammation of intrahepatic bile ducts. This end-stage disease was once the most common cause of liver transplantation. The use of ursodeoxycholic and obeticholic acids as a first-line and second-line treatment, respectively, slows down the disease. However, treatment is not effective in about 40% of PBC patients, and the disease may progress to cirrhosis and end-stage liver disease. These patients undergo liver transplantation to save their lives. After surgery, recurrent PBC can develop in a milder form and rarely requires liver retransplantation.https://journal.transpl.ru/vtio/article/view/1469primary biliary cholangitispbcliver transplantationrecurrence pbcrisk factors |
| spellingShingle | I. M. Iljinsky O. M. Tsirulnikova Liver transplantation for primary biliary cholangitis (review) Вестник трансплантологии и искусственных органов primary biliary cholangitis pbc liver transplantation recurrence pbc risk factors |
| title | Liver transplantation for primary biliary cholangitis (review) |
| title_full | Liver transplantation for primary biliary cholangitis (review) |
| title_fullStr | Liver transplantation for primary biliary cholangitis (review) |
| title_full_unstemmed | Liver transplantation for primary biliary cholangitis (review) |
| title_short | Liver transplantation for primary biliary cholangitis (review) |
| title_sort | liver transplantation for primary biliary cholangitis review |
| topic | primary biliary cholangitis pbc liver transplantation recurrence pbc risk factors |
| url | https://journal.transpl.ru/vtio/article/view/1469 |
| work_keys_str_mv | AT imiljinsky livertransplantationforprimarybiliarycholangitisreview AT omtsirulnikova livertransplantationforprimarybiliarycholangitisreview |