Pharmacokinetics of Maternal Drug Administration: Insights into Placental Transfer and Fetal Exposure
Pregnancy profoundly influences the pharmacokinetics of maternally administered drugs, necessitating a comprehensive understanding of placental transfer and fetal exposure for safe and effective drug therapy. This review provides an updated overview of recent advancements in the field, comprising pl...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_1215_24 |
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| author | Abdullah Duhaim Tariq Abdullah Almatroudi Zaiad Abdullah Alghidani Abdulsalam Saad Alhunayni Mohamed Helmy Salama |
| author_facet | Abdullah Duhaim Tariq Abdullah Almatroudi Zaiad Abdullah Alghidani Abdulsalam Saad Alhunayni Mohamed Helmy Salama |
| author_sort | Abdullah Duhaim |
| collection | DOAJ |
| description | Pregnancy profoundly influences the pharmacokinetics of maternally administered drugs, necessitating a comprehensive understanding of placental transfer and fetal exposure for safe and effective drug therapy. This review provides an updated overview of recent advancements in the field, comprising placental anatomy and physiology, pharmacokinetic changes during pregnancy, factors affecting placental transfer, techniques for studying transfer mechanisms, and clinical implications for maternal and fetal health. Recent discoveries explaining placental structure, function, and molecular transport mechanisms underscore the complexity of drug transfer across the placental barrier. Advances in pharmacokinetic research reveal dynamic alterations in drug absorption, distribution, metabolism, and excretion during pregnancy, which impact therapeutic drug levels and maternal-fetal outcomes. Factors influencing placental transfer, including drug properties, placental transporters, and maternal-fetal physiology, are increasingly recognized as critical determinants of fetal exposure. Innovative methodologies and technologies facilitate the study of placental drug transport, offering insights into drug-specific transfer kinetics and developmental risks. |
| format | Article |
| id | doaj-art-830e5c546be74d9394b7c98440b98351 |
| institution | Kabale University |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-830e5c546be74d9394b7c98440b983512025-01-13T10:23:45ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062024-12-0116Suppl 4S3743S374510.4103/jpbs.jpbs_1215_24Pharmacokinetics of Maternal Drug Administration: Insights into Placental Transfer and Fetal ExposureAbdullah DuhaimTariq Abdullah AlmatroudiZaiad Abdullah AlghidaniAbdulsalam Saad AlhunayniMohamed Helmy SalamaPregnancy profoundly influences the pharmacokinetics of maternally administered drugs, necessitating a comprehensive understanding of placental transfer and fetal exposure for safe and effective drug therapy. This review provides an updated overview of recent advancements in the field, comprising placental anatomy and physiology, pharmacokinetic changes during pregnancy, factors affecting placental transfer, techniques for studying transfer mechanisms, and clinical implications for maternal and fetal health. Recent discoveries explaining placental structure, function, and molecular transport mechanisms underscore the complexity of drug transfer across the placental barrier. Advances in pharmacokinetic research reveal dynamic alterations in drug absorption, distribution, metabolism, and excretion during pregnancy, which impact therapeutic drug levels and maternal-fetal outcomes. Factors influencing placental transfer, including drug properties, placental transporters, and maternal-fetal physiology, are increasingly recognized as critical determinants of fetal exposure. Innovative methodologies and technologies facilitate the study of placental drug transport, offering insights into drug-specific transfer kinetics and developmental risks.https://journals.lww.com/10.4103/jpbs.jpbs_1215_24maternal drug administrationpharmacokineticsplacental transfer |
| spellingShingle | Abdullah Duhaim Tariq Abdullah Almatroudi Zaiad Abdullah Alghidani Abdulsalam Saad Alhunayni Mohamed Helmy Salama Pharmacokinetics of Maternal Drug Administration: Insights into Placental Transfer and Fetal Exposure Journal of Pharmacy and Bioallied Sciences maternal drug administration pharmacokinetics placental transfer |
| title | Pharmacokinetics of Maternal Drug Administration: Insights into Placental Transfer and Fetal Exposure |
| title_full | Pharmacokinetics of Maternal Drug Administration: Insights into Placental Transfer and Fetal Exposure |
| title_fullStr | Pharmacokinetics of Maternal Drug Administration: Insights into Placental Transfer and Fetal Exposure |
| title_full_unstemmed | Pharmacokinetics of Maternal Drug Administration: Insights into Placental Transfer and Fetal Exposure |
| title_short | Pharmacokinetics of Maternal Drug Administration: Insights into Placental Transfer and Fetal Exposure |
| title_sort | pharmacokinetics of maternal drug administration insights into placental transfer and fetal exposure |
| topic | maternal drug administration pharmacokinetics placental transfer |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_1215_24 |
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