Diagnosis and management of de novo inflammatory bowel disease after solid organ transplantation in the era of biologic therapy: a case series
IntroductionThe clinical characteristics of de novo inflammatory bowel disease (dnIBD) diagnosed after solid organ transplant (SOT) are not well-described, particularly since the advent of biologic therapy for treatment of IBD.MethodsWe conducted a single-center, retrospective review of SOT recipien...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Transplantation |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/frtra.2024.1483943/full |
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| author | Willie Mohammed Johnson Byron P. Vaughn Nicholas Lim |
| author_facet | Willie Mohammed Johnson Byron P. Vaughn Nicholas Lim |
| author_sort | Willie Mohammed Johnson |
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| description | IntroductionThe clinical characteristics of de novo inflammatory bowel disease (dnIBD) diagnosed after solid organ transplant (SOT) are not well-described, particularly since the advent of biologic therapy for treatment of IBD.MethodsWe conducted a single-center, retrospective review of SOT recipients between 2010 and 2022 at the University of Minnesota Medical Center who were diagnosed with IBD after transplant.ResultsOf 89 patients at our center with IBD and a history of SOT, five (5.6%) patients were diagnosed with IBD post-transplant (three liver, one kidney, and one simultaneous liver and kidney): three patients were female and four were Caucasian. Mean age at transplant and IBD diagnosis were 46.7 and 49.4 years respectively. Indication for transplant were alcohol-related cirrhosis (n = 2), idiopathic fulminant hepatic failure (n = 1), metabolic dysfunction-associated steatotic liver disease (n = 1), and IgA nephropathy (n = 1). Four patients were diagnosed with ulcerative colitis (UC) and one with Crohn's disease (CD). Three patients (all with UC) required escalation to a biologic therapy. Four patients were in clinical remission from IBD at last follow-up, one patient required IBD surgery, while there was no rejection and no deaths following IBD diagnosis.ConclusiondnIBD post-SOT is uncommon, while newer IBD therapies may be safe and effective. Further study is required to better understand the natural history and IBD outcomes of this population relative to non-SOT patients. |
| format | Article |
| id | doaj-art-82e2b46d01dd46d2a7102a5e8231d807 |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Transplantation |
| spelling | doaj-art-82e2b46d01dd46d2a7102a5e8231d8072025-01-08T06:12:01ZengFrontiers Media S.A.Frontiers in Transplantation2813-24402025-01-01310.3389/frtra.2024.14839431483943Diagnosis and management of de novo inflammatory bowel disease after solid organ transplantation in the era of biologic therapy: a case seriesWillie Mohammed Johnson0Byron P. Vaughn1Nicholas Lim2Department of Medicine, University of Minnesota, Minneapolis, MN, United StatesDivision of Gastroenterology, Hepatology and Nutrition, University of Minnesota, Minneapolis, MN, United StatesDivision of Gastroenterology, Hepatology and Nutrition, University of Minnesota, Minneapolis, MN, United StatesIntroductionThe clinical characteristics of de novo inflammatory bowel disease (dnIBD) diagnosed after solid organ transplant (SOT) are not well-described, particularly since the advent of biologic therapy for treatment of IBD.MethodsWe conducted a single-center, retrospective review of SOT recipients between 2010 and 2022 at the University of Minnesota Medical Center who were diagnosed with IBD after transplant.ResultsOf 89 patients at our center with IBD and a history of SOT, five (5.6%) patients were diagnosed with IBD post-transplant (three liver, one kidney, and one simultaneous liver and kidney): three patients were female and four were Caucasian. Mean age at transplant and IBD diagnosis were 46.7 and 49.4 years respectively. Indication for transplant were alcohol-related cirrhosis (n = 2), idiopathic fulminant hepatic failure (n = 1), metabolic dysfunction-associated steatotic liver disease (n = 1), and IgA nephropathy (n = 1). Four patients were diagnosed with ulcerative colitis (UC) and one with Crohn's disease (CD). Three patients (all with UC) required escalation to a biologic therapy. Four patients were in clinical remission from IBD at last follow-up, one patient required IBD surgery, while there was no rejection and no deaths following IBD diagnosis.ConclusiondnIBD post-SOT is uncommon, while newer IBD therapies may be safe and effective. Further study is required to better understand the natural history and IBD outcomes of this population relative to non-SOT patients.https://www.frontiersin.org/articles/10.3389/frtra.2024.1483943/fullsolid organ transplantCrohn's diseaseulcerative colitisimmunosuppressioninflammatory bowel disease |
| spellingShingle | Willie Mohammed Johnson Byron P. Vaughn Nicholas Lim Diagnosis and management of de novo inflammatory bowel disease after solid organ transplantation in the era of biologic therapy: a case series Frontiers in Transplantation solid organ transplant Crohn's disease ulcerative colitis immunosuppression inflammatory bowel disease |
| title | Diagnosis and management of de novo inflammatory bowel disease after solid organ transplantation in the era of biologic therapy: a case series |
| title_full | Diagnosis and management of de novo inflammatory bowel disease after solid organ transplantation in the era of biologic therapy: a case series |
| title_fullStr | Diagnosis and management of de novo inflammatory bowel disease after solid organ transplantation in the era of biologic therapy: a case series |
| title_full_unstemmed | Diagnosis and management of de novo inflammatory bowel disease after solid organ transplantation in the era of biologic therapy: a case series |
| title_short | Diagnosis and management of de novo inflammatory bowel disease after solid organ transplantation in the era of biologic therapy: a case series |
| title_sort | diagnosis and management of de novo inflammatory bowel disease after solid organ transplantation in the era of biologic therapy a case series |
| topic | solid organ transplant Crohn's disease ulcerative colitis immunosuppression inflammatory bowel disease |
| url | https://www.frontiersin.org/articles/10.3389/frtra.2024.1483943/full |
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