Marine-Derived Compounds Combined with Nanoparticles: A Focus on the Biomedical and Pharmaceutical Sector
The ocean is an extraordinary natural source of a wide range of bioactive compounds. These compounds, including proteins, phenolics, polysaccharides, pigments, vitamins, and fatty acids, possess unique biological properties that are increasingly being explored in the field of nanotechnology across d...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-05-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/23/5/207 |
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| author | Laura M. Teixeira Catarina P. Reis Rita Pacheco |
| author_facet | Laura M. Teixeira Catarina P. Reis Rita Pacheco |
| author_sort | Laura M. Teixeira |
| collection | DOAJ |
| description | The ocean is an extraordinary natural source of a wide range of bioactive compounds. These compounds, including proteins, phenolics, polysaccharides, pigments, vitamins, and fatty acids, possess unique biological properties that are increasingly being explored in the field of nanotechnology across diverse sectors. Among marine-derived nanoparticles, promising applications have emerged in the biomedical and pharmaceutical fields, particularly metallic nanoparticles and polysaccharide-based drug delivery systems. This review provides a unique perspective on the integration of two research areas: the exploration of marine bioresources as bioactive compounds sources with nanotechnological methodologies to develop sustainable, safe, stable and functional marine-derived NPs. It highlights recent advancements in the green synthesis of MNPs and the formulation of drug delivery systems using marine polysaccharides. This review also describes the recent trends over the past ten years and discusses the major challenges and limitations associated with these approaches, including variability in biological sources, batch-to-batch inconsistency, mechanistic uncertainties, and difficulties in reproducibility and scalability. Furthermore, it emphasizes the need for standardized protocols and the integration of life cycle assessments (LCA) to evaluate environmental and economic viability for effective translating marine-derives nanoparticles from research to clinical applications. |
| format | Article |
| id | doaj-art-82dbb412f4904a86a6b35ba9c6f1bb0c |
| institution | Kabale University |
| issn | 1660-3397 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj-art-82dbb412f4904a86a6b35ba9c6f1bb0c2025-08-20T03:47:57ZengMDPI AGMarine Drugs1660-33972025-05-0123520710.3390/md23050207Marine-Derived Compounds Combined with Nanoparticles: A Focus on the Biomedical and Pharmaceutical SectorLaura M. Teixeira0Catarina P. Reis1Rita Pacheco2Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, PortugalInstitute for Medicines (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, 1649-003 Lisboa, PortugalCentro de Química Estrutural, Institute of Molecular Sciences, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, PortugalThe ocean is an extraordinary natural source of a wide range of bioactive compounds. These compounds, including proteins, phenolics, polysaccharides, pigments, vitamins, and fatty acids, possess unique biological properties that are increasingly being explored in the field of nanotechnology across diverse sectors. Among marine-derived nanoparticles, promising applications have emerged in the biomedical and pharmaceutical fields, particularly metallic nanoparticles and polysaccharide-based drug delivery systems. This review provides a unique perspective on the integration of two research areas: the exploration of marine bioresources as bioactive compounds sources with nanotechnological methodologies to develop sustainable, safe, stable and functional marine-derived NPs. It highlights recent advancements in the green synthesis of MNPs and the formulation of drug delivery systems using marine polysaccharides. This review also describes the recent trends over the past ten years and discusses the major challenges and limitations associated with these approaches, including variability in biological sources, batch-to-batch inconsistency, mechanistic uncertainties, and difficulties in reproducibility and scalability. Furthermore, it emphasizes the need for standardized protocols and the integration of life cycle assessments (LCA) to evaluate environmental and economic viability for effective translating marine-derives nanoparticles from research to clinical applications.https://www.mdpi.com/1660-3397/23/5/207marine bioactive compoundsnanoparticlesgreen synthesismarine polysaccharidesdrug delivery systems |
| spellingShingle | Laura M. Teixeira Catarina P. Reis Rita Pacheco Marine-Derived Compounds Combined with Nanoparticles: A Focus on the Biomedical and Pharmaceutical Sector Marine Drugs marine bioactive compounds nanoparticles green synthesis marine polysaccharides drug delivery systems |
| title | Marine-Derived Compounds Combined with Nanoparticles: A Focus on the Biomedical and Pharmaceutical Sector |
| title_full | Marine-Derived Compounds Combined with Nanoparticles: A Focus on the Biomedical and Pharmaceutical Sector |
| title_fullStr | Marine-Derived Compounds Combined with Nanoparticles: A Focus on the Biomedical and Pharmaceutical Sector |
| title_full_unstemmed | Marine-Derived Compounds Combined with Nanoparticles: A Focus on the Biomedical and Pharmaceutical Sector |
| title_short | Marine-Derived Compounds Combined with Nanoparticles: A Focus on the Biomedical and Pharmaceutical Sector |
| title_sort | marine derived compounds combined with nanoparticles a focus on the biomedical and pharmaceutical sector |
| topic | marine bioactive compounds nanoparticles green synthesis marine polysaccharides drug delivery systems |
| url | https://www.mdpi.com/1660-3397/23/5/207 |
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