Central Pulse Wave Velocity and Augmentation Index Are Repeatable and Reproducible Measures of Arterial Function
Abstract Background and Aims Arterial function (specifically arterial stiffness) is an important cardiovascular risk factor. Pulse wave velocity (PWV) and augmentation index (Alx) are established indicators of arterial function. The present study aimed to evaluate the repeatability and reproducibili...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-11-01
|
| Series: | Health Science Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/hsr2.70155 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846151697781489664 |
|---|---|
| author | Sophie L. Russell Mushidur Rahman Charles J. Steward Amy E. Harwood Gordon McGregor Prithwish Banerjee Nduka C. Okwose Djordje G. Jakovljevic |
| author_facet | Sophie L. Russell Mushidur Rahman Charles J. Steward Amy E. Harwood Gordon McGregor Prithwish Banerjee Nduka C. Okwose Djordje G. Jakovljevic |
| author_sort | Sophie L. Russell |
| collection | DOAJ |
| description | Abstract Background and Aims Arterial function (specifically arterial stiffness) is an important cardiovascular risk factor. Pulse wave velocity (PWV) and augmentation index (Alx) are established indicators of arterial function. The present study aimed to evaluate the repeatability and reproducibility of PWV and Alx in healthy individuals. Methods Forty healthy participants (age 33 ± 11 years, 17 females) underwent resting supine PWV and Alx assessments. Measurements were made in triplicate and repeated 1 week apart. Alx was measured by brachial occlusion and PWV was measured from the carotid artery to the femoral artery via the tonometer‐oscillometric method. Repeatability and reproducibility were assessed using the intraclass correlation coefficient (ICC). Interoperator reproducibility was performed on 10 participants. Results The average values for week‐to‐week visits for PWV and Alx were 6.20 ± 0.91 versus 6.13 ± 0.91 ms−1 and 14.0 ± 11.8 versus 16.3 ± 12.2% respectively. For same‐day measurements, both PWV and Alx showed excellent repeatability (PWV: ICC = 0.96, 95% CI: 0.92–0.98, p < 0.01; Alx: ICC = 0.90, 95% CI: 0.84–0.94, p < 0.01) and interoperator reproducibility (PWV: ICC = 0.98, 95% CI: 0.93–1.00, p < 0.01; Alx: ICC = 0.93, 95% CI: 0.69–0.98, p < 0.01). Measurements were repeated 1 week apart and showed good reproducibility (PWV: ICC = 0.77, 95% CI: 0.61–0.87, p ≤ 0.01; Alx: ICC = 0.73, 95% CI: 0.73–0.86, p < 0.01). Conclusion PWV and Alx demonstrate excellent repeatability and good reproducibility. Considering these variables are noninvasive and easy‐to‐measure, arterial function assessment may have a role in routine clinical practice to facilitate risk stratification in cardiovascular diseases. |
| format | Article |
| id | doaj-art-82d3254c07014d69b7b2d109ab7093a0 |
| institution | Kabale University |
| issn | 2398-8835 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj-art-82d3254c07014d69b7b2d109ab7093a02024-11-27T05:20:45ZengWileyHealth Science Reports2398-88352024-11-01711n/an/a10.1002/hsr2.70155Central Pulse Wave Velocity and Augmentation Index Are Repeatable and Reproducible Measures of Arterial FunctionSophie L. Russell0Mushidur Rahman1Charles J. Steward2Amy E. Harwood3Gordon McGregor4Prithwish Banerjee5Nduka C. Okwose6Djordje G. Jakovljevic7Research Centre for Health and Life Sciences (CHLS) Coventry University Coventry UKResearch Centre for Health and Life Sciences (CHLS) Coventry University Coventry UKResearch Centre for Physical Activity, Sport and Exercise Science (CPASES) Coventry University Coventry UKDepartment of Sport and Exercise Sciences, Institute of Sport Manchester Metropolitan University Manchester UKResearch Centre for Healthcare and Communities Coventry University Coventry UKResearch Centre for Health and Life Sciences (CHLS) Coventry University Coventry UKResearch Centre for Health and Life Sciences (CHLS) Coventry University Coventry UKResearch Centre for Health and Life Sciences (CHLS) Coventry University Coventry UKAbstract Background and Aims Arterial function (specifically arterial stiffness) is an important cardiovascular risk factor. Pulse wave velocity (PWV) and augmentation index (Alx) are established indicators of arterial function. The present study aimed to evaluate the repeatability and reproducibility of PWV and Alx in healthy individuals. Methods Forty healthy participants (age 33 ± 11 years, 17 females) underwent resting supine PWV and Alx assessments. Measurements were made in triplicate and repeated 1 week apart. Alx was measured by brachial occlusion and PWV was measured from the carotid artery to the femoral artery via the tonometer‐oscillometric method. Repeatability and reproducibility were assessed using the intraclass correlation coefficient (ICC). Interoperator reproducibility was performed on 10 participants. Results The average values for week‐to‐week visits for PWV and Alx were 6.20 ± 0.91 versus 6.13 ± 0.91 ms−1 and 14.0 ± 11.8 versus 16.3 ± 12.2% respectively. For same‐day measurements, both PWV and Alx showed excellent repeatability (PWV: ICC = 0.96, 95% CI: 0.92–0.98, p < 0.01; Alx: ICC = 0.90, 95% CI: 0.84–0.94, p < 0.01) and interoperator reproducibility (PWV: ICC = 0.98, 95% CI: 0.93–1.00, p < 0.01; Alx: ICC = 0.93, 95% CI: 0.69–0.98, p < 0.01). Measurements were repeated 1 week apart and showed good reproducibility (PWV: ICC = 0.77, 95% CI: 0.61–0.87, p ≤ 0.01; Alx: ICC = 0.73, 95% CI: 0.73–0.86, p < 0.01). Conclusion PWV and Alx demonstrate excellent repeatability and good reproducibility. Considering these variables are noninvasive and easy‐to‐measure, arterial function assessment may have a role in routine clinical practice to facilitate risk stratification in cardiovascular diseases.https://doi.org/10.1002/hsr2.70155arterial functionaugmentation indexpulse wave velocityreliability |
| spellingShingle | Sophie L. Russell Mushidur Rahman Charles J. Steward Amy E. Harwood Gordon McGregor Prithwish Banerjee Nduka C. Okwose Djordje G. Jakovljevic Central Pulse Wave Velocity and Augmentation Index Are Repeatable and Reproducible Measures of Arterial Function Health Science Reports arterial function augmentation index pulse wave velocity reliability |
| title | Central Pulse Wave Velocity and Augmentation Index Are Repeatable and Reproducible Measures of Arterial Function |
| title_full | Central Pulse Wave Velocity and Augmentation Index Are Repeatable and Reproducible Measures of Arterial Function |
| title_fullStr | Central Pulse Wave Velocity and Augmentation Index Are Repeatable and Reproducible Measures of Arterial Function |
| title_full_unstemmed | Central Pulse Wave Velocity and Augmentation Index Are Repeatable and Reproducible Measures of Arterial Function |
| title_short | Central Pulse Wave Velocity and Augmentation Index Are Repeatable and Reproducible Measures of Arterial Function |
| title_sort | central pulse wave velocity and augmentation index are repeatable and reproducible measures of arterial function |
| topic | arterial function augmentation index pulse wave velocity reliability |
| url | https://doi.org/10.1002/hsr2.70155 |
| work_keys_str_mv | AT sophielrussell centralpulsewavevelocityandaugmentationindexarerepeatableandreproduciblemeasuresofarterialfunction AT mushidurrahman centralpulsewavevelocityandaugmentationindexarerepeatableandreproduciblemeasuresofarterialfunction AT charlesjsteward centralpulsewavevelocityandaugmentationindexarerepeatableandreproduciblemeasuresofarterialfunction AT amyeharwood centralpulsewavevelocityandaugmentationindexarerepeatableandreproduciblemeasuresofarterialfunction AT gordonmcgregor centralpulsewavevelocityandaugmentationindexarerepeatableandreproduciblemeasuresofarterialfunction AT prithwishbanerjee centralpulsewavevelocityandaugmentationindexarerepeatableandreproduciblemeasuresofarterialfunction AT ndukacokwose centralpulsewavevelocityandaugmentationindexarerepeatableandreproduciblemeasuresofarterialfunction AT djordjegjakovljevic centralpulsewavevelocityandaugmentationindexarerepeatableandreproduciblemeasuresofarterialfunction |