A murine model of acute and prolonged abdominal sepsis, supported by intensive care, reveals time-dependent metabolic alterations in the heart

A murine model of acute and prolonged abdominal sepsis, supported by intensive care, reveals time-dependent metabolic alterations in the heart

Abstract Background Sepsis-induced cardiomyopathy (SICM) often occurs in the acute phase of sepsis and is associated with increased mortality due to cardiac dysfunction. The pathogenesis remains poorly understood, and no specific treatments are available. Although SICM is considered reversible, emer...

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Bibliographic Details
Main Authors: Bart Jacobs, Inge Derese, Sarah Derde, Sarah Vander Perre, Lies Pauwels, Greet Van den Berghe, Jan Gunst, Lies Langouche
Format: Article
Language:English
Published: SpringerOpen 2025-01-01
Series:Intensive Care Medicine Experimental
Subjects:
Sepsis
Sepsis-induced cardiomyopathy
Heart
Metabolism
Inflammation
Mitochondrial oxidation
Online Access:https://doi.org/10.1186/s40635-025-00715-1
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