Impact of dysregulated microbiota-derived C18 polyunsaturated fatty acid metabolites on arthritis severity in mice with collagen-induced arthritis

Impact of dysregulated microbiota-derived C18 polyunsaturated fatty acid metabolites on arthritis severity in mice with collagen-induced arthritis

ObjectiveWe aimed to evaluate microbiome and microbiota-derived C18 dietary polyunsaturated fatty acids (PUFAs), such as conjugated linoleic acid (CLA), and to investigate their differences that correlate with arthritis severity in collagen-induced arthritis (CIA) mice.MethodsOn day 84 after inducti...

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Bibliographic Details
Main Authors: Katsuhiko Yoneda, Sho Sendo, Takaichi Okano, Hidenori Shimizu, Hirotaka Yamada, Keisuke Nishimura, Yo Ueda, Jun Saegusa
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
metabolome
rheumatoid arthritis
16S rRNA
collagen-induced arthritis
polyunsaturated fatty acids
gut microbiota-derived metabolites
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1444892/full
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