Histoplasmosis associated hemophagocytosis- a rare cause of pancytopenia in an immunocompetent patient
Pancytopenia as a result of hemophagocytosis in a middle-aged man presenting with high-grade fever of unknown etiology could be a rare consequence of Histoplasmosis infection. In the past, many cases of patients with human immunodeficiency virus infection contracting histoplasmosis-induced hemophago...
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| Language: | English |
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Association of Clinical Pathologists of Nepal
2024-10-01
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| Series: | Journal of Pathology of Nepal |
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| Online Access: | https://www.nepjol.info/index.php/JPN/article/view/59030 |
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| author | Mansimran Kaur Menka Khanna Karamjit Singh Hitesh Marwaha |
| author_facet | Mansimran Kaur Menka Khanna Karamjit Singh Hitesh Marwaha |
| author_sort | Mansimran Kaur |
| collection | DOAJ |
| description | Pancytopenia as a result of hemophagocytosis in a middle-aged man presenting with high-grade fever of unknown etiology could be a rare consequence of Histoplasmosis infection. In the past, many cases of patients with human immunodeficiency virus infection contracting histoplasmosis-induced hemophagocytosis have been well documented, however, little data has been entered in the setting of HIV non-reactive status. Interestingly, we report a case of histoplasmosis in an immunocompetent male with the presence of yeast forms of H. capsulatum in the bone marrow smears. The patient was subsequently placed on Amphotericin B and corticosteroids but lost to the infectious disease. Cases like this, highlight the importance of taking into account the early decision for bone marrow sampling with careful attention to microscopic details as incidental pathologies may be elicited which could have significant effects on patient’s prognosis. |
| format | Article |
| id | doaj-art-82b477636e1f4c8eafaf1b470cf33588 |
| institution | Kabale University |
| issn | 2091-0797 2091-0908 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Association of Clinical Pathologists of Nepal |
| record_format | Article |
| series | Journal of Pathology of Nepal |
| spelling | doaj-art-82b477636e1f4c8eafaf1b470cf335882025-08-21T06:55:17ZengAssociation of Clinical Pathologists of NepalJournal of Pathology of Nepal2091-07972091-09082024-10-011412180218210.3126/jpn.v14i1.5903086134Histoplasmosis associated hemophagocytosis- a rare cause of pancytopenia in an immunocompetent patientMansimran Kaur0https://orcid.org/0009-0007-8623-4869Menka Khanna1Karamjit Singh2Hitesh Marwaha3Sri Guru Ram Das Institute of Medical Sciences and Research, AmritsarSri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, PunjabSri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, PunjabSri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, PunjabPancytopenia as a result of hemophagocytosis in a middle-aged man presenting with high-grade fever of unknown etiology could be a rare consequence of Histoplasmosis infection. In the past, many cases of patients with human immunodeficiency virus infection contracting histoplasmosis-induced hemophagocytosis have been well documented, however, little data has been entered in the setting of HIV non-reactive status. Interestingly, we report a case of histoplasmosis in an immunocompetent male with the presence of yeast forms of H. capsulatum in the bone marrow smears. The patient was subsequently placed on Amphotericin B and corticosteroids but lost to the infectious disease. Cases like this, highlight the importance of taking into account the early decision for bone marrow sampling with careful attention to microscopic details as incidental pathologies may be elicited which could have significant effects on patient’s prognosis.https://www.nepjol.info/index.php/JPN/article/view/59030bone marrowhistoplasmosispancytopenia |
| spellingShingle | Mansimran Kaur Menka Khanna Karamjit Singh Hitesh Marwaha Histoplasmosis associated hemophagocytosis- a rare cause of pancytopenia in an immunocompetent patient Journal of Pathology of Nepal bone marrow histoplasmosis pancytopenia |
| title | Histoplasmosis associated hemophagocytosis- a rare cause of pancytopenia in an immunocompetent patient |
| title_full | Histoplasmosis associated hemophagocytosis- a rare cause of pancytopenia in an immunocompetent patient |
| title_fullStr | Histoplasmosis associated hemophagocytosis- a rare cause of pancytopenia in an immunocompetent patient |
| title_full_unstemmed | Histoplasmosis associated hemophagocytosis- a rare cause of pancytopenia in an immunocompetent patient |
| title_short | Histoplasmosis associated hemophagocytosis- a rare cause of pancytopenia in an immunocompetent patient |
| title_sort | histoplasmosis associated hemophagocytosis a rare cause of pancytopenia in an immunocompetent patient |
| topic | bone marrow histoplasmosis pancytopenia |
| url | https://www.nepjol.info/index.php/JPN/article/view/59030 |
| work_keys_str_mv | AT mansimrankaur histoplasmosisassociatedhemophagocytosisararecauseofpancytopeniainanimmunocompetentpatient AT menkakhanna histoplasmosisassociatedhemophagocytosisararecauseofpancytopeniainanimmunocompetentpatient AT karamjitsingh histoplasmosisassociatedhemophagocytosisararecauseofpancytopeniainanimmunocompetentpatient AT hiteshmarwaha histoplasmosisassociatedhemophagocytosisararecauseofpancytopeniainanimmunocompetentpatient |